|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications显示文摘The intestinal lumen is a host place for a wide range of microbiota and sets a unique interplay between local immune system, inflammatory cells and intestinal epithelium, forming a physical barrier against microbial invaders and toxins. Bacterial translocation is the migration of viable or nonviable microorganisms or their pathogen-associated molecular patterns, such as lipopolysaccharide, from the gut lumen to the mesenteric lymph nodes, systemic circulation and other normally sterile extraintestinal sites. A series of studies have shown that translocation of bacteria and their products across the intestinal barrier is a commonplace in patients with liver disease. The deterioration of intestinal barrier integrity and the consulting increased intestinal permeability in cirrhotic patients play a pivotal pathophysiological role in the development of severe complications as high rate of infections, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome, variceal bleeding, progression of liver injury and hepatocellular carcinoma. Nevertheless, the exact cellular and molecular mechanisms implicated in the phenomenon of microbial translocation in liver cirrhosis have not been fully elucidated yet. | Georgios I Tsiaoussis Stelios F Assimakopoulos Athanassios C Tsamandas Christos K Triantos Konstantinos C Thomopoulos | 2015 | World Journal of Hepatology2015，7，17： | 4 |
| 2 | Effect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus:A review显示文摘Cardiovascular disease is the predominant cause of death in type 2 diabetes mellitus(T2DM).Evidence suggests a strong association between duration and degree of hyperglycemia and vascular disease.However,large trials failed to show cardiovascular benefit after intensive glycemic control,especially in patients with longer diabetes duration.Atherosclerosis is a chronic and progressive disease,with a long asymptomatic phase.Subclinical atherosclerosis,which is impaired in T2DM,includes impaired vasodilation,increased coronary artery calcification(CAC),carotid intima media thickness,arterial stiffness,and reduced arterial elasticity.Each of these alterations is represented by a marker of subclinical atherosclerosis,offering a cost-effective alternative compared to classic cardiac imaging.Their additional use on top of traditional risk assessment strengthens the predictive risk for developing coronary artery disease(CAD).We,herein,review the existing literature on the effect of glycemic control on each of these markers separately.Effective glycemic control,especially in earlier stages of the disease,attenuates progression of structural markers like intima-media thickness and CAC.Functional markers are improved after use of newer antidiabetic agents,such as incretin-based treatments or sodium-glucose cotransporter-2 inhibitors,especially in T2DM patients with shorter disease duration.Larger prospective trials are needed to enhance causal inferences of glycemic control on clinical endpoints of CAD. | Sofia Antoniou Katerina K K Naka Marios Papadakis Aris Bechlioulis Agathocles Tsatsoulis Lampros K Michalis Stelios Tigas | 2021 | World Journal of Diabetes2021，12，11： | 2 |
| 3 | Comparatives Study of the Separation of Casein from Bovine,Ovine and Caprine Milks Using HPLC 显示文摘 | STELIOS E K | 1993 | Journal of Dairy Research1993，60，： | 1 |
| 4 | Test set generation with a large number of unspecified bits using static and dynamic techniques 显示文摘 | STELIOS N N MARIA K M | 2010 | IEEE Transactions on Computers2010，59，3： | 1 |
| 5 | Modelling fish growth: Model selection, multi- model inference and model selection uncertainty 显示文摘 | Stelios K | 2006 | Fisher- ies Research2006，81，： | 1 |
| 6 | HLA-DR expressing peripheral T regulatory cells in newly diagnosed patients with different forms of autoimmune thyroid disease显示文摘 | Stelios F George V Nikolaos K | 2008 | Thyroid2008，18，11： | 1 |
| 7 | Differential expression of fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditis 显示文摘 | Stelios F George V Nikolaos K | 2008 | Eur Endocrinol2008，158，6： | 1 |
| 8 | Oxidative stress in patients with COPD显示文摘 | Stelios L Petros B Konstantinos K | 2011 | Current Drug Targets2011，12，4： | 1 |
| 9 | High prevalence of subclinical peripheral artery disease in Greek hospitalized patients显示文摘 | Stavros A Stelios K Fotini S | 2005 | Eur J of Intern Med2005，16，3： | 1 |
| 10 | A Robust Fuzzy Local Information C-means Clustering Algorithm显示文摘 | Stelios K Vassilios C | 2010 | IEEE Transactions on Image Processing2010，19，5： | 1 |
| 11 | Study of organic acids, volatile fraction and caseins of a new Halloumi-typ cheese during ripening in whey brine显示文摘 | STELIOS K PARASKEVI S THEOPHILOS M | 2009 | Int J Food Sci Technol2009，44，2： | 1 |
| 12 | A robust fuzzy local information C-Means clustering algorithm显示文摘 | STELIOS K VASSILIOS C | 2010 | IEEE Transction on Image Processing2010，19，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员