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| 1 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 2 | Acute upper gastrointestinal bleeding in octοgenarians:Clinical outcome and factors related to mortality显示文摘AIM: To evaluate the aetiology, clinical outcome and factors related to mortality of acute upper gastrointestinal bleeding (AUGIB) in octogenarians. METHODS: We reviewed the records of all patients over 65 years old who were hospitalised with AUGIB in two hospitals from January 2006 to December of 2006. Patients were divided into two groups: Group A (65-80 years old) and Group B (> 80 years old). RESULTS: Four hundred and sixteen patients over 65 years of age were hospitalized because of AUGIB. Group A included 269 patients and Group B 147 patients. Co-morbidity was more common in octogenarians (P = 0.04). The main cause of bleeding was peptic ulcer in both groups. Rebleeding and emergency surgery were uncommon in octogenarians and not different from those in younger patients. In-hospital complications were more common in octogenarians (P = 0.05) and more patients died in the group of octogenarians compared to the younger age group (P = 0.02). Inability to perform endoscopic examination (P = 0.002), presence of high risk for rebleeding stigmata (P = 0.004), urea on admission (P = 0.036), rebleeding (P = 0.004) and presenceof severe co-morbidity (P < 0.0001) were related to mortality. In multivariate analysis, only the presence of severe co-morbidity was independently related to mortality (P = 0.032). CONCLUSION: While rebleeding and emergency surgery rates are relatively low in octogenarians with AUGIB, the presence of severe co-morbidity is the main factor of adverse outcome. | George J Theocharis Vassiliki Arvaniti Stelios F Assimakopoulos Konstantinos C Thomopoulos Vassilis Xourgias Irini Mylonakou Vassiliki N Nikolopoulou | 2008 | World Journal of Gastroenterology2008，14，25： | 15 |
| 3 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 4 | Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: Not just trefoil peptides显示文摘Bombesin and neurotensin are neuropeptides which exert a wide spectrum of biological actions on gastrointestinal tissues influencing intestinal growth and adaptation, intestinal motility, blood flow, secretion, nutrient absorption and immune response. Based mainly on their well-established potent enterotrophic effect, numerous experimental studies investigated their potential positive effect on the atrophic or injured intestinal mucosa. These peptides proved to be effective mucosa-healing factors, but the potential molecular and cellular mechanisms for this action remained unresolved. In a recently published study (World J Gastroenterol 2008; 14(8): 1222-1230), it was shown that their protective effect on the intestine in experimentally induced inflammatory bowel disease was related to anti-inflammatory, antioxidant and antiapoptotic actions. These results are in close agreement with our previous studies on jaundiced and hepatectomized rats that showed a regulatory effect of bombesin and neurotensin on critical cellular processes such as enterocyte' proliferation and death, oxidative stress and redox equilibrium, tight junctions' formation and function, and inflammatory response. The pleiotropic effects of bombesin and neurotensin on diverse types of intestinal injury may justify their consideration for clinical trials. | Stelios F Assimakopoulos Chrisoula D Scopa Vassiliki N Nikolopoulou Constantine E Vagianos | 2008 | World Journal of Gastroenterology2008，14，22： | 4 |
| 5 | On array failure mitigation using genetic algorithms and a priori joint optimization 显示文摘 | Stelios A Mifilineos Christos N Capsalis | 2005 | IEEE Antennas and Propagation Magazine2005，47，4： | 1 |
| 6 | On array failure mitigation with respect to probability of failure, using constant excitation coefficients and a genetic algorithm显示文摘 | Stelios A Mifilineos Stelios C A Thomopoulos Christos N Capsalis | 2006 | IEEE Antennas and Wireless Propagation Letters2006，5，1： | 1 |
| 7 | Test set generation with a large number of unspecified bits using static and dynamic techniques 显示文摘 | STELIOS N N MARIA K M | 2010 | IEEE Transactions on Computers2010，59，3： | 1 |
| 8 | Elderly adults with COVID-19 admitted to intensive care unit:A narrative review显示文摘BACKGROUND In the context of the Coronavirus disease 2019(COVID-19)pandemic,it has been reported that elderly patients are particularly at risk of developing severe illness and exhibiting increased mortality.While many studies on hospitalized elderly patients with COVID-19 have been published,limited information is available on the characteristics and clinical outcomes of those elderly patients admitted to intensive care unit(ICU).AIM To review the available evidence of the clinical data of elderly patients admitted to the ICU due to COVID-19.METHODS We searched for published articles available in English literature to identify those studies conducted in critically ill patients admitted to the ICU due to COVID-19,either exclusively designed for the elderly or for the whole ICU population with COVID-19,provided that analyses according to the patients’age had been conducted.RESULTS Only one study exclusively focusing on critically ill elderly patients admitted to the ICU due to COVID-19 was found.Eighteen additional studies involving 17011 ICU patients and providing information for elderly patients as a subset of the whole study population have also been included in the present review article.Among the whole patient population,included in these studies,8310 patients were older than 65 years of age and 2630 patients were older than 70 years.Clinical manifestations were similar for all patients;however,compared to younger ones,they suffered from more comorbidities and showed a varied,albeit high mortality.CONCLUSION In summary,at present,although elderly patients constitute a considerable proportion of critically ill patients admitted to the ICU due to severe COVID-19,studies providing specific information are limited.The evidence so far suggests that advanced age and comorbidities are associated with worse clinical outcome.Future studies exclusively designed for this vulnerable group are needed. | Aikaterini Gkoufa Eleni Maneta Georgios N Ntoumas Vasiliki E Georgakopoulou Athina Mantelou Stelios Kokkoris Christina Routsi | 2021 | World Journal of Critical Care Medicine2021，10，5： | 0 |
| 9 | 立意·忘象显示文摘古往今来,"象""意"之辩一直争论不休。在哲学中,《道德经》有述"大音希声,大象无形",一种理解是美妙的音律不能用声音来表达,真正的大道没有形式的束缚;在文学创作中,有讲究"得意忘象""得象忘言",意思即不能过分拘泥于文字与现象,而应直达其背后的意义;同样,在绘画中也有对形式之美与抽象表现主义的思辨。 | Arturo lvarez Kengo Kuma Maxim Velcovsky LASVIT Nikos Sideris+CTRLZAK Antonella Picci Pulsar Moonlight Hannakaisa Pekkala Tim Vanlier Santiago Lena Cristián Mohaded Richard Yasmine Niamh Barry Stelios Mousarris Jan Blythe 彭佳 | 2017 | 现代装饰2017，0，8： | 0 |
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