|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 2 | Diferential localization of heat shock ptotein 90,70,60 and 27 in human decid- uas and placenta during pregnancy显示文摘 | Shah M Stanek J Handwerger S | 1998 | Histochem J1998，30，7： | 1 |
| 3 | Prognostic evaluation of neurohumoral plasma levels before and during B-blocker therapy in advanced left ventricular dysfunction显示文摘 | Stanek B Frey B Hulsmann M | 2001 | J Am Coll Cardiol2001，38，2： | 1 |
| 4 | Determination of thermal diffusivity and thermal conductivity of Mg-A1 alloys 显示文摘 | Rudajevova A Stanek M Lukac P | 2003 | Materials Science and Engineering A2003，341，： | 1 |
| 5 | Value of eardiopulmonary exercise testing and big endothelin plasma levels to predict short- term prognosis of patients with chronic heart failure 显示文摘 | Hulsmann M Stanek B Frey B | 1998 | J Am Coll Cardiol1998，32，6： | 1 |
| 6 | Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure显示文摘 | Pacher R Stanek B Hulsmann M | 1996 | J Am Coll Cardiol1996，27，3： | 1 |
| 7 | Measuring alliance value and risk: a model approach to prioritizing alliance projects显示文摘 | STANEK M B | 2004 | Management Decision2004，，42： | 1 |
| 8 | Effect of prostaglandin E1 infusion in severe chronic heart failure显示文摘 | Pacher R Stanek B Htilsmann M | 1997 | Prostaglandins1997，53，4： | 1 |
| 9 | Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction显示文摘 | Stanek B Frey B Hülsmann M | | 0，，02： | 1 |
| 10 | Hormesis and stage specific toxicity induced by cadmium in an insect model,the queen blowfly, Phormia regina Meig显示文摘 | NASCARELLA M A STOFFOLANO J G Jr STANEK E J 3rd | 2003 | Environ Pollut2003，124，： | 1 |
| 11 | Diferential localization of heat shock protein 90,70,60 and 27 in human decid- uas and placenta during pregnancy显示文摘 | Shall M Stanek J Handwerger S | 1998 | Histochem J1998，30，7： | 1 |
| 12 | Orognostic evalua- tion of neurofruin-ocal plasma levels before and during be- ta-blocker therapy in advanced left ventricular dysfunction显示文摘 | STANEK B FREY B HULSMANN M | 2001 | J Am Col Cardiol2001，38，2： | 1 |
| 13 | Prognostic evaluation of neurohumoral plasma levels before and during β-blocker therapy in advance left ventricular dysfunction显示文摘 | Frey B Hulsmann M | 2001 | J Am Coil Cardiol2001，38，： | 1 |
| 14 | Prognostic eva-luation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction显示文摘 | Stanek B Frey B Hulsmann M | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 15 | Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction 显示文摘 | Stanek B Frey B Htilsmann M | 2001 | J Am Coil Cardiol2001，38，2： | 1 |
| 16 | Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure显示文摘 | Berger R Stanek B Hulsmann M | 2001 | Circulation2001，103，7： | 1 |
| 17 | On the calculation of breakdown voltages for uniform electric fields in compressed air and SF6 显示文摘 | Abdel-Salam M Stanek E K | 1988 | IEEETrans on Industry Applications1988，24，6： | 1 |
| 18 | Mathematical-physicalmodel of corona from surges on high-voltage lines 显示文摘 | Abdel-Salam M Stanek E K | 1987 | IEEE Transactions on Industry Applications1987，23，48： | 1 |
| 19 | Prognostic evaluation of neurohumoral plasma levels before and during p-locker therapy in advance left ventricular dysfunction显示文摘 | Stanek B Frey B Hulsmann M | 2001 | J Am Coil Cardiol2001，38，2： | 1 |
| 20 | Prognostic evaluation of neurohumoral plasma levels before and during P-blocker therapy in advance left ventricular dysfunction显示文摘 | Stanek B Frey B Hulsmann M | 2001 | J Am Coil Cardiol2001，38，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员