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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Is serum vitamin D levels associated with disability in patients with newly diagnosed multiple sclerosis 显示文摘 | Hatamian H Bidabadi E Seyed SSM | 2013 | Iran J Nenro12013，12，2： | 1 |
| 3 | Cost - effectiveness analysis on screening for colarectal neoplasm and manage- ment of colorectal cancer in Asia 显示文摘 | Tsoi KKF Ng SSM Leung MCM | 2008 | Alimentary Pharma- cology & Therapeutics2008，28，3： | 1 |
| 4 | Emotional incontinence in Chinese stroke patients diagnosis,frequency,and clinical and radiological correlates显示文摘 | Tang WK Chan SSM | 2004 | J Neurol2004，251，7： | 1 |
| 5 | The functional gastrointestinal disorders and the Rome - process显示文摘 | Dm ssm an D A | 2006 | Gastroenterology2006，130，5： | 1 |
| 6 | Treatment of pyogenic liver abscess: prospective randomized comparison of catheter drainage and needle aspiration显示文摘 | YU SCH HO SSM LAU WY | 2004 | Hepatology2004，39，4： | 1 |
| 7 | Cultivable bacteria in infected root canals as identified by 16S rRNA gene sequencing 显示文摘 | Siqueira JF Jr Rocas IN Paiva SSM | 2007 | Oral Mierobiol Immunol2007，22，4： | 1 |
| 8 | Cultivable bacteria in infected root eanals as identified by 16S rRNA gene sequencing 显示文摘 | Siqueira JF Jr Rocas IN Paiva SSM | 2007 | Oral Microbiol Immunol2007，22，4： | 1 |
| 9 | Compartmentation of caffeine and related purine alkaloids depends exclusively on the physical chemistry of their vacuolar complex formation with chlorogenic acids 显示文摘 | Waldhauser SSM Baumann TW | 1996 | Phyto- chemistry1996，42，4： | 1 |
| 10 | 显示文摘 | Habeebu SSM | 1998 | Toxicol Appl Pharmacol1998，149，： | 1 |
| 11 | ECG-correlated image reconstruction from subseeond multi-slice spiral CT scans of heart显示文摘 | Kaehelrie SSM Ulzheimer S Kalender WA | 2000 | Med Phys2000，27，8： | 1 |
| 12 | Does the use of TENS increase the effectiveness of exercise for improving walking after stroke? A randomized controlled clinical trial显示文摘 | Ng SSM Hui-Chan CWY | 2009 | Clin Rehabil2009，23，12： | 1 |
| 13 | Transcutaneous electrical stimulation on acupoints combined with task-related training to improve motor function and walking performance in an individual 7 years poststroke: a case study显示文摘 | Ng SSM Hui-Chan CWY | 2010 | J Neurol Phys Ther2010，34，4： | 1 |
| 14 | Cadmium induced apoptosis in mouse liver显示文摘 | Habeebu SSM Liu J Klaassen CD | 1998 | Toxicol Appl Pharmacol1998，149，： | 1 |
| 15 | ECG-correlated image reconstruction from subsecond multi-slice spiral CT scans of heart显示文摘 | Kachelrie SSM Ulzheimer S Kalender WA | 2000 | MED Phys2000，27，8： | 1 |
| 16 | Selective determination of thiamine (vitamin B1) in pharmaceutical preparations by direct potentiometric argentometric titration withuse of the silver-silver sulfide ion-selective electrode显示文摘 | Hassan SSM Elnemma E | 1989 | Talanta1989，36，10： | 1 |
| 17 | Polypol pathway in diabetic microvascular diseases显示文摘 | Chung SSM Chung SK | 2005 | J Hong Kong College Cardiology2005，13，2： | 1 |
| 18 | Emotional incontinence in Chinese st roke patient s 显示文摘 | Tang WK Chan SSM Chiu HFK | 2004 | J Neurol2004，25，1： | 1 |
| 19 | Association of angiogenesis markers with lymph node metastasis in early colorectal cancer显示文摘 | Iddings DM Koda EA Grewal SSMS | | 0，，： | 1 |
| 20 | Expression and activation of STAT proteins during mouse retina development显示文摘 | Zhang SSM Wei JY Li CJ | | 0，，： | 1 |
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