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| 1 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 2 | Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children显示文摘AIM: To investigate whether Helicobacter pylori (H pykori)infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure.METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital inSalvador, Brazil.H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) werefound to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence ofHpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for bothHpyloriand HAV antibodies (χ2 = 7.18,OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI1.02-5.03). The agreement between H pylori and HAVseropositivity was fair (κ = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pyloriwere age,presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4,95%CI, 1.1-5.1).CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted. | Edson Duarte Moreira Jr Victor Bastos Nassri Rafaela Sousa Santos Junísia Ferraz Matos Wilson Andrade de Carvalho Célia Stolve Silvani Círia Santana e Sant'Ana | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 3 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 4 | Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review显示文摘Oxidative stress,inflammation,and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus.Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years.Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress,inflammation,and diabetes mellitus.Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system,resulting in the amelioration of glucose homeostasis in diabetic conditions.This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties,their sources,range of dosage,and the intervention time in experiments with animals and clinical trials.This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits. | Diego Cabral Lacerda Paulo César Trindade da Costa Paula Brielle Pontes Lucas Alves Carneiro dos Santos JoséPatrocínio Ribeiro Cruz Neto Cristiane Cosmo Silva Luis Vanessa Polyana de Sousa Brito JoséLuiz de Brito Alves | 2022 | World Journal of Diabetes2022，13，9： | 3 |
| 5 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 6 | Optimisation of shape and process parameters in metal forging using genetic algorithms显示文摘 | CASTRO C F ANTONIO C A C SOUSA L C | 2004 | Journal of Material Processing Technology2004，146，3： | 1 |
| 7 | Use of Raman micro-spectroscopy in the characterization of M^Ⅱ Fe2O4 (M= Fe, Zn) electric double layer ferrofluids 显示文摘 | Sousa M H Tourinho F A Rubim J C | 2000 | J Raman Spec2000，31，： | 1 |
| 8 | Innate antiviral responses by means of TLRT-mediated recognition of single-stranded RNA显示文摘 | Diebold S S Kaisho T Hemmi H Akira S Reis e Sousa C | 2004 | Science2004，303，： | 1 |
| 9 | Mesoscale SPH modeling of fluid flow in isotropic porous media显示文摘 | Jiang F M Oliveira M C A Sousa A C M | 2007 | Compu Phys Commun2007，176，： | 1 |
| 10 | Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children 显示文摘 | Dale RC de Sousa C Chong WK | 2000 | Brain2000，2，12312： | 1 |
| 11 | Computer generated graphite pencil rendering of 3D polygonal models显示文摘 | Sousa M C Buchanan J W | 1999 | Computer Graphics Forum1999，18，3： | 1 |
| 12 | An ex-ploratory analysis of relationships between socioeconom- ic, land use, activity participation variables and travel pat- terns 显示文摘 | PITOMBO C S KAWAMOTO E SOUSA A J | 2011 | Transport Policy2011，，18： | 1 |
| 13 | A distribu- ted concurrency control mechanism for XML data 显示文摘 | Moreura L O SOUSA F R C MACHADO J C | 2011 | Journal of Compute and System Science2011，38，9： | 1 |
| 14 | Wnt2 regulates progenitor proliferation in the developing ventral midbrain 显示文摘 | Sousa K M Villaescusa J C Cajanek L | 2010 | Journal of Biological Chemistry2010，285，10： | 1 |
| 15 | Computer-generated graphite pencil rendering of 3D polygonal models显示文摘 | J W Buchanan | 1999 | Computer Graphics Forum1999，18，3： | 1 |
| 16 | Sketch-based modeling:a survey显示文摘 | Olsen L Samavati F F Sousa M C | 2009 | Computers & Graphics2009，33，1： | 1 |
| 17 | Clinical management and subsequent healing of teeth with horizontal root fractures 显示文摘 | Versiani MA de Sousa C J Cruz-Filho AM | 2008 | Dent Traumatol2008，24，1： | 1 |
| 18 | Mesoporous silica-magnetite nanocomposite synthesized by using a neutral surfactant显示文摘 | Souza K C Salazar-Alvarez G Ardisson J D Macedo W A A Sousa E M B | 2008 | Nanotechnology2008，19，18： | 1 |
| 19 | Activation of dendritic cells: translating in nate into adaptive immunity显示文摘 | Reis E Sousa C | 2004 | Curr Opin Immunol2004，16，： | 1 |
| 20 | Innate recognition of viruses 显示文摘 | Pichlmair A Reis e Sousa C | 2007 | Immunity2007，27，3： | 1 |
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