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	题名	作者	年代	出处	被引量
1	FOLFOX/FOLFIRI pharmacogenetics:The call for a personalized approach in colorectal cancer therapy显示文摘While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20%,the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival.However,the side effects of systemic therapy such as myelotoxicity,neurotoxicity or gastrointestinal toxicity may lead to life-threatening complications and have a major impact on the quality of life of the patients.Therefore,biomarkers that would be instrumental in the choice of optimal type,combination and dose of drugs for an individual patient are urgently needed.The efficacy and toxicity of anticancer drugs in tumor cells is determined by the effective concentration in tumor cells,healthy tissues and by the presence and quantity of the drug targets.Enzymes active in drug metabolism and transport represent important determinants of the therapeutic outcome.The aim of this review was to summarize published data on associations of gene and protein expression,and genetic variability of putative biomarkers with response to therapy of colorectal cancer to 5-fluorouracil/leucovorin/oxaliplatin and 5-fluorouracil/leukovorin/irinotecan regimens.Gaps in the knowledge identified by this review may aid the design of future research and clinical trials.	Beatrice Mohelnikova-Duchonova Bohuslav Melichar Pavel Soucek	2014	World Journal of Gastroenterology2014，20，30：	2
2	Cytochromes P-450 in rats: structures, functions, properties and relevant human forms 显示文摘	Soucek P Gut I	1992	Xenobiotica1992，22，1：	1
3	Novel Anticaneer Platinum (IV) Complexes with Adamantylamine:Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism 显示文摘	Kozubik A Vaculov6 A Soucek K	2008	Met Based Drugs2008，2008，41：	1
4	Ornithine decarboxylase G316A genotype and colorectal cancer risk显示文摘	Hughes D J HlavatáI Soucek P	2011	Colorectal Dis2011，13，8：	1
5	Mung bean sprouts (Phaseolus aureus) nuclease and its biological and antitumor effects显示文摘	Soucek J Skvor J Pouckova P	2006	Neoplasma2006，53，：	1
6	The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide显示文摘	Schubert D Soucek T Blouw B	2009	Eur J Neurosci2009，29，7：	1
7	BAALC expressionand FLT3 internal tandem duplication mutations in acute myeloidleukemia patients with normal cytogenetics:prognostic implications显示文摘	Baldus CD Thiede C Soucek S	2006	J Clin Oncol2006，24，5：	1
8	An integrative assessment of a watershed impacted by abandoned mined land discharges 显示文摘	CHERRY D S CURRIE R J SOUCEK D J	2001	Environmental Pollution2001，111，3：	1
9	Ultraviolet Curing Kinetics of Cyclosliphstic Epoxide with Real-Time Fourier Transform Infrared Spectroscopy显示文摘	CHEN J X SOUCEK M D		0，，09：	1
10	Comparison of titanium-oxo-clusters derived from sol-gel precursors with TiO2 nanoparticles in drying oil based ceramer coatings macromol显示文摘	Deffar D Teng G H Soucek M D	2001	Mater Eng2001，，286：	1
11	Photoinitiated Cationic Polymerization of Cycloaliphatic Epoxide with Siloxane or Alkoxysilane Functionalized Polyol Coatings显示文摘	Soucek M D	2003	Eur Polym J2003，39，3：	1
12	Enzymic hydrolysis of sphingomyelins by a toxin of Corynebacterium ovis显示文摘	Soucek A Michalec C Souckova A	1967	Biochim Biophys Acta1967，144，1：	1
13	Synthesis and characterization of cycloaliphatic diepoxide crosslinkable core-shell latexes显示文摘	Soucek M D Teng G	2001	Polymer2001，42，：	1
14	Different cell cycle modulation following trealmem of human ovarian carcinoma cells with a new platinum(IV)complex vs cisptmin显示文摘	Soucek K Svihalkova-Sindlerova L	2007	Invest New Drugs2007，25，5：	1
15	A new class of acrylated alkyds 显示文摘	DZICZKOWSKI J SOUCEK M D	2010	Journal of Coatings Technology and Research2010，7，5：	1
16	Hypertension and car- diovascular complications of chronic renal failure 显示文摘	Soucek M Monhart V Nedbdlkovd M	2011	Vnitr Lek2011，57，61：	1
17	Communication systems for building automation and control 显示文摘	KASTNER W NEUGSCHWANDTNER G SOUCEK S	2005	Proceedings of the IEEE2005，93，6：	1
18	Hypertonic-hyperoncotic volume replacement with Tensitone显示文摘	Vokrouhlicky L Soucek R	1998	Gas Lek Cesk1998，137，5：	1
19	Crosslinking of acrylic latex coatings with cycloaliphatic diepoxide 显示文摘	WU S SOUCEK M D	2000	Polymer2000，41，6：	1
20	Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors显示文摘	Soucek L Lawlor ER Soto D		0，，10：	1

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