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	题名	作者	年代	出处	被引量
1	Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team.	Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel	2014	World Journal of Gastroenterology2014，20，42：	5
2	Prevention of gliotic scar for-mation by NeuroGel allows partial endogenous repair of transected cat spinal cord显示文摘	Doan VD Sosa N	2004	J Neurosei Res2004，75，2：	1
3	Prevention of gliotic scar formation by NeuroGel al ows partial endogenous repair of transected cat spinal cord显示文摘	Woerly S Doan VD Sosa N		0，，02：	1
4	Encapsulation of citral in formulations containing sucrose or trehalose: Enmlsions properties and stability显示文摘	SOSA N SCHEBOR C PEREZ O E	2014	Food and Bioproducts Processing2014，92，3：	1
5	Micellar extraction of organophosphorus pesticides and their determination by liquid chromatography显示文摘	C. Padrón Sanz R. Halko Z. Sosa Ferrera J.J. Santana Rodr??guez	2004	Analytica Chimica Acta2004，，1：	1
6	Risk factors for postpartum hemorrhage in vaginal deliveries in a Latin-American population显示文摘	Sosa CG Althabe F Belizán JM		0，，06：	1
7	Effect of physical prop- erties on the stability of Lactobacillus bulgaricus in a freeze-dried galacto-oligosaccharides matrix 显示文摘	Tymczyszyn E E Sosa N Gerbino E	2012	Int J Food Microbiol2012，155，3：	1
8	A comparison of poly(vinyl acetatex with high solid contnet made by emulsion and semi-continuous microemulsion polymerization显示文摘	Sosa N R G Lopez L F Ramos Katime I	2001	Polymer2001，42，：	1
9	查看详情显示文摘	Sosa A V Ochoa J Perotti N I		0，，：	1
10	Age, growth and maturation of jumbo squid Dosidicus gigas ( Cephalopoda: Onmmstrephidae) from the Gulf of California, Mexico 显示文摘	MARKAIDA U QUINONEZ V C SOSA N O	2004	Fisheries Research2004，66，1：	1
11	A comparison of the characteristics of poly (vinyl acetate) latex with high solid content made by emulsion and semi-continuous microemulsion polymerization 显示文摘	SOSA N PERALTA R D LOPEZ R G	2001	Polymer2001，42，16：	1
12	Transient dynamic response of piezoelectric bodies subjected to internal electric impulses显示文摘	Sosa H Khutoryansky N	1999	International Journal of Solids and Structures1999，36，9：	1
13	A 3D numerical model for reinforced and prestressed con- crete elements subjected to combined axial, bending,shear and torsion loading 显示文摘	GREGORI J N SOSA P M PRADA M A F	2007	Engineering Strutctures2007，29，12：	1
14	Prevention of gliotie sear formation by Neuro(;e endogenous repair of transeeted eat spinal cord显示文摘	Woerlv S Doan VS Sosa N	2004	J Nenrosci Hes2004，75，2：	1
15	Abacavir and lamivudine fixed-dose combination tablet once-daily compared with abaeavir and lamivudine twice-daily in HIV-1 infected patients over 48 weeks (ESS30008, SEAL) 显示文摘	Sosa N Hill-Zabala C Dejesus E	2005	J Acquir Immune Defic Syndr2005，40，4：	1
16	Modeling of direct recovery of lactic acid from whole broths by ion exchange adsorption显示文摘	Sosa A V Ochoa J Perotti N I	2000	Bioseparation2000，9，：	1
17	Comparision of the characteristics of poly(vinyl acetate) latex with high solid content made by emulsion and semi-continuous microemulsion polymerization显示文摘	N Sosa R D Peralta R G López	2001	Polymer2001，，42：	1
18	A comparison of the characteristics of poly( vinyl acetate) latex with high solid content made by emulsion and semi-continuous microemulsion polymerization 显示文摘	N Sosa R D Peralta R G lopez	2001	Polymer2001，42，：	1
19	Novel compensation of axial thermal expansion in ball screw drives显示文摘	De Sosa I N Bucht A Junker T	2014	Machine Tool2014，，3：	1
20	Prevention of Gliotic Scar Forma- tion by NeuroGelTM Allows Partial Endogenous Repair of Transee- ted Cat Spinal Cord显示文摘	Woedy S Doan V D Sosa N	2004	Journal of Neuroscience Research2004，5，2：	1

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