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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 3 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 4 | Response surface methodological study on lipase-catalyzed synthesis of amino acid surfactants显示文摘 | Soo EL Salleh AB Basri M | 2004 | Process Biochemistry2004，39，： | 1 |
| 5 | Comparison of computer simu- lation of reactive distillation using ASPEN PLUS and HYSYS software 显示文摘 | SAMEJKAL Q SOOS M | 2002 | Chem Eng Process2002，41，5： | 1 |
| 6 | Comparison of the effectiveness of two internationally recommended screening methods for the diagnosis of gestational diabetes显示文摘 | Salamon M Soos Z Olah R | 2013 | Orv Hetil2013，154，20： | 1 |
| 7 | External knowledge acquisition, creativity and learning in or- ganisational problem solving 显示文摘 | Soo C W Devinney T M Midgley D F | 2007 | International Jour- nal of Technology Management2007，38，12： | 1 |
| 8 | Interferon-τ Prospects for Clinical Use in Autoimmune Disorders 显示文摘 | Soos J M Johnson H M | 1999 | BioDrugs1999，11，2： | 1 |
| 9 | A low complexity selected mapping scheme by use of time domain se-quence superposition technique for PAPR reduction in OFDM system显示文摘 | YANG L SOO K K SIU Y M | 2008 | IEEE Transactions on Broadcast-ing2008，54，4： | 1 |
| 10 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 11 | The dynamic relation between stock returns and trading volume: Domestic: and cross - country evidence 显示文摘 | LEE Bong - Soo RUI 0 M | 2002 | Journal of banking and finance2002，，26： | 1 |
| 12 | Using a two-step deposition technique to prepare perovskite (MAPbI3) for thin film solar cells based on ZrO2 and TiO2 mesostructures显示文摘 | Dong Q B Soo J M Leif H | 2013 | RSC Adv2013，3，18： | 1 |
| 13 | Design of a general purpose 6-DOF haptic interface 显示文摘 | Soo S Lee Jang M Lee | 2003 | Mechatronics2003，，13： | 1 |
| 14 | Population balance modeling of aggregation and breakage in turbulent Taylor - Cou- ette flow 显示文摘 | Soos M Wang L Fox R O | 2007 | Journal of Colloid and Interface Science2007，307，2： | 1 |
| 15 | Quality of life of patients with epilepsy显示文摘 | Lain J Rozsavolgyi M Soos G | 2001 | Hungarian Survey Seizure2001，10，： | 1 |
| 16 | Comparison of computer simulation of reactive distillation using ASPEN PLUS and HYSYS software显示文摘 | Samejkal Q Soos M | 2002 | Chem Eng Process2002，41，5： | 1 |
| 17 | Chordoma:review of clinicoradiological features and factors affecting survival显示文摘 | Soo M Y | 2001 | Australas Radiol2001，45，4： | 1 |
| 18 | Comparison of computer simulation of reactive distillation using ASPEN PLUS and HYSYS software显示文摘 | Soos M | 2002 | Chem Eng Process2002，41，5： | 1 |
| 19 | Bim links ER stress and apoptosis in ceils expressing mutant SOD1 associated with amyotrophic lateral sclerosis 显示文摘 | Soo KY Atkin JD Farg M | 2012 | PLoS One2012，7，35： | 1 |
| 20 | Radiosurgery of brain metastases with the gamma knife显示文摘 | Soo Y Takanash M | 1996 | Stereotact Funct Neuro Surg1996，66，1： | 1 |
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