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| 1 | The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry显示文摘雄激素在前列腺癌症致病起一个中央作用,并且因此病人的大多数对雄激素剥夺治疗作出回应。然而,病人们与好攻击的前列腺癌症趋于到恶化,它是被称为荷尔蒙倔强。识别调停的蛋白质前进到荷尔蒙倔强的状态,我们为病人的 sera 介绍的质量使用了蛋白质薄片技术。这研究与变形荷尔蒙倔强的前列腺癌症包括了 16 个病人开始与雄激素剥夺被对待治疗。浆液样品在五个次点从每个病人被收集:点 A,预告的处理;削尖 B,在前列腺特定的抗原(PSA ) 的天底水平;点 C, PSA 失败;点 D,早荷尔蒙倔强的阶段;并且削尖 E,晚荷尔蒙倔强的阶段。用提高表面的激光解吸附作用 / 电离 time-of-flight 团 spectrometry,我们执行了病人的 sera 介绍的蛋白质质量并且识别了与疾病前进增加了的 6 640-Da 山峰。目标蛋白质部分被净化,并且由氨基酸定序,山峰作为 apolipoprotein C-I 的碎片被识别(ApoC -- 我) 。浆液 ApoC -- 我蛋白质层次与疾病前进增加了。在 immunohistochemical 分析上, ApoC -- 我蛋白质被发现局部性到荷尔蒙倔强的癌症房间的细胞质。在这研究,我们在浆液 ApoC 显示出增加 -- 我蛋白质在他们的前进期间在前列腺癌症病人铺平到荷尔蒙倔强的状态,它建议那 ApoC -- 我蛋白质与前列腺癌症的前进有关。然而, ApoC 的准确角色 -- 我在前列腺癌症致病是不清楚的,进一步的研究被要求。 | Kaori Yamamoto-Ishikawa Hiroyoshi Suzuki Masahiko Nezu Naoto Kamiya Takashi Imamoto Akira Komiya Kazuyuki Sogawa Takeshi Tomonaga Fumlo Nomur Tomohiko Ichikawa | 2009 | Asian Journal of Andrology2009，11，3： | 3 |
| 2 | Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease显示文摘AIM To assess how serum gamma-glutamyltransferase(GGT) fractions vary in patients with alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD). METHODS Serum samples were obtained from 14 patients with biopsy-proven alcoholic liver diseases and 9 patients with biopsy proven non-alcoholic fatty liver disease. In addition to these biopsy-proven cases, 16 obese(body mass index > 25) patients without any history of alcohol consumption but with a fatty liver on ultrasound examination and with elevated GGT were included for an additional analysis. Serum GGT fractionation was conducted by high-performance gel filtration liquid chromatography and was separated into the four fractions, big-GGT, medium-GGT, small-GGT(s-GGT), and free-GGT(f-GGT).RESULTS The results were expressed as a ratio of each fraction including the total GGT(t-GGT). The s-GGT/t-GGT ratioswere lowest for the control group and highest for the ALD group. The differences between the control and NAFLD groups and also between the NAFLD and ALD groups were statistically significant. In contrast, the f-GGT/t-GGT ratios were highest in the control group and lowest in the ALD group, with the differences being statistically significant. As a result, the s-GGT/f-GGT ratios were markedly increased in the NAFLD group as compared with the control group. The increase of the s-GGT/t-GGT ratios, the decrease of the f-GGT/t-GGT ratios, and the increase of s-GGT/F-GGT ratios as compared with the control group subjects were also found in obese patients with clinically diagnosed fatty change of the liver.CONCLUSION Serum GGT fractionation by high-performance gel filtration liquid chromatography is potentially useful for the differential diagnosis of ALD and NAFLD. | Shigeo Sueyoshi Setsu Sawai Mamoru Satoh Masanori Seimiya Kazuyuki Sogawa Atsushi Fukumura Mikihiro Tsutsumi Fumio Nomura | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 3 | Postoperative urinary retention after surgery for benign anorectal disease: potential risk factors and strategy for prevention显示文摘 | Takayuki Toyonaga Makoto Matsushima Nobuhito Sogawa Song Feng Jiang Naomi Matsumura Yasuhiro Shimojima Yoshiaki Tanaka Kazunori Suzuki Junnichi Masuda Masao Tanaka | 2006 | International Journal of Colorectal Disease2006，，7： | 2 |
| 4 | Effect of chlorine dioxide on avian influenza A(H7N9)virus显示文摘Avian influenza remains a threat to human wellbeing.Hypochlorite derivatives are commonly used as disinfectants to prevent the spread of the disease.The World Health Organization(WHO)has listed chlorine dioxide(ClO_(2))as an A1‐level,safe,and efficient disinfectant.In this study,we tested the efficacy of ClO_(2),in aqueous solution and gas forms,against avian influenza A(H7N9)virus.The virus suspension was mixed with ClO_(2) aqueous solutions of various concentrations and for various time intervals.Aliquots of the mixture were then serially diluted,and the 50%tissue culture infective dose(TCID50)was measured with a hemagglutination test on MDCK cells.ClO_(2) gas produced from generators was introduced in a chamber containing the virus suspension in a Petri dish.The infective activity of the surviving virus was measured by the hemagglutination test.An aqueous solution of ClO_(2) at 126μg/mL for 15 s was effective given that no surviving virus was detected with the hemagglutination test.ClO_(2) gas at>5μL/L sustained for 1 h inactivated the virus effectively,while at 2.5μL/L for 1 h,it only partially inactivated the virus.ClO_(2) as gas or aqueous solution at a certain concentration is effective in inactivating the H7N9 virus,and can be applied for the decontamination and disinfection of environments. | Zhiping Sun Yun Qian Norio Ogata Xia Cai Wendong Han Youhua Xie Hirofumi Morino Koushirou Sogawa Takashi Shibata Di Qu | 2022 | Biosafety and Health2022，4，1： | 2 |
| 5 | Timing of ketogenic di- etinitiation in an experimental epilepsy model显示文摘 | Su SW Cilio MR Sogawa Y | 2000 | Brain Res Dev Brain Res2000，125，12： | 1 |
| 6 | Identification of novel and downregulated biomarkers for alcoholism by surface enhanced laser desorption/ionization-mass spectrometry显示文摘 | Nomura F Tomonaga T Sogawa K | 2004 | Proteomies2004，4，4： | 1 |
| 7 | Influence of stress on the maturity of T cells显示文摘 | Teshima H Sogawa H Kihara H | 1991 | Life Science1991，49，： | 1 |
| 8 | cDNA cloning and tran- scriptional properties of a novel GC box - binding protein, 4 BTEB2 显示文摘 | Sogawa K lmataka H Yamasaki Y | 1993 | Nucleic Acids Research1993，21，7： | 1 |
| 9 | Postoperative urinary retention after surgery for benign anorectal disease: potential risk factors and strategy for prevention显示文摘 | TOYONAGA T MATSUSHIMA M SOGAWA N | 2006 | Int J Colorectal Dis2006，21，7： | 1 |
| 10 | Studies on Multivari- ate Conditional Maximum Entropy Distribution and Its Characteristics显示文摘 | Sogawa N Araki M Imai T | 1986 | Journal of Hydroscience and Hydraulic Engineering1986，4，1： | 1 |
| 11 | Multicentfic Castleman disease with secondary AA renal amyloidosis, nephrotic syndrome and chronic renal failure, remission after high-dose melphalan and autologous stem cell transplantation 显示文摘 | Ogita M Hoshino J Sogawa Y | 2007 | Clin Nephro12007，68，3： | 1 |
| 12 | Isolation of Human,Swine,and Rat Prepepsinogens and Calf Preprochymosin and Determination of the Primary Structures of Their NH2-Terminal Signal Sequences显示文摘 | Ichihara Y Sogawa K Takahashi K | 1985 | Biochem1985，98，： | 1 |
| 13 | Primary Structure of Human Pepsinogen Gene显示文摘 | Sogawa K Fujii-Kuriyama Y Mizugaki Y | 1983 | Biochem1983，258，： | 1 |
| 14 | Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells显示文摘 | SOGAWA K SUMIDA T HAMAKAWA H | 1998 | Research Communications in Molecular Pathology and Pharmacology1998，99，3： | 1 |
| 15 | Antibiotic use during in- fancy promotes a shift in the T(H)I/T(H)2 balance toward T (H)2-dominant immunity in mice显示文摘 | Oyama N Sudo N Sogawa H | 2001 | J Allergy Clin Immunol2001，107，1： | 1 |
| 16 | A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene显示文摘 | Yanagida A Sogawa K Yasumoto KI | 1990 | Mol Cell Biol1990，10，： | 1 |
| 17 | Photon-spin controlled lasing oscillation in surface-emitting lasers 显示文摘 | Ando H Sogawa T Gotoh H | 1998 | Appl Phys Lett1998，73，5： | 1 |
| 18 | Use of the MALDI Biotyper system with MALDI-TOF mass spectrometry for rapid identification of microorganisms显示文摘 | SOGAWA K WATANABE M SATO K | 2011 | Anal Bioanal Chem2011，400，7： | 1 |
| 19 | Long-term effects of status epilepticus in the immature brain are specific for age and model显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilepsia2003，44，4： | 1 |
| 20 | Postoperative urinary retention 'after surgery for benign anorectal disease:potential risk factors and strategy for prevention 显示文摘 | Toyonaga T Matsushima M Sogawa N | 2006 | Int J Colorectal Dis2006，21，7： | 1 |
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