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| 1 | Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis显示文摘AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours. | Sophie E Moore Rosana E Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott | 2017 | World Journal of Psychiatry2017，7，1： | 12 |
| 2 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 3 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 4 | Rhein reverses the diabetic phenotype of mesangial cells over‐expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway显示文摘 | J‐MZheng J‐MZhu L‐SLi Z‐HLiu | 2009 | British Journal of Pharmacology2009，，7： | 2 |
| 5 | Management der postpartalen Blutung (PPH)显示文摘 | D. Schlembach M.G. M?rtl T. Girard W. Arzt E. Beinder C. Brezinka K. Chalubinski D. Fries W. Gogarten B.-J. Hackel?er H. Helmer W. Henrich I. H?sli P. Husslein F. Kainer U. Lang G. Pfanner W. Rath E. Schleussner H. Steiner D. Surbek R. Zimmermann | 2014 | Der Anaesthesist2014，，3： | 2 |
| 6 | Prevention of adult asthma by early intervention during childhood : potential value of new generation immunomodulatory drugs 显示文摘 | Holt P G Sly P D | 2000 | Thorax2000，55，8： | 1 |
| 7 | Natriuretic peptides, antidiuretic hormone and hyponatraemia after acute craniocerebral injury 显示文摘 | Zhang W SLi Visocchi M Jiang J | 2008 | J Int Med Res2008，36，： | 1 |
| 8 | Japanese Corporate Govern- ance: Structural Change and Financial Performance 显示文摘 | sli M C Torn Y Takashi H | 2007 | Asian Business & Management2007，，6： | 1 |
| 9 | Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment显示文摘 | Holt PG Sly PD | 2012 | Nat Med2012，18，5： | 1 |
| 10 | Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology显示文摘 | Sinuhe Hahn Stavros Giaglis Chanchal Sur Chowdury Irene H?sli Paul Hasler | 2013 | Seminars in Immunopathology2013，，4： | 1 |
| 11 | Reference values of interrupter respiratory resistance in healthy preschool white children显示文摘 | Lombardi E Sly PD Concutelli G | 2001 | Thorax2001，56，9： | 1 |
| 12 | Factors predisposing to abnormal pulmonary function after adenovirus type 7 pneumonia显示文摘 | Sly P D Me S Q LI L | 1984 | Arch Dis Child1984，59，： | 1 |
| 13 | Survival of Mycobacteriu*n tuberculosis in host macro- phages involves resistance to apoptosis dependent upon induction of antiapoptotic Bel-2 family member McI-1显示文摘 | Sly LM Hingley-Wilson SM | 2003 | J Immunol2003，170，1： | 1 |
| 14 | Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a T H 2-skewed immune response显示文摘 | Stephanie T. Yerkovich Marjut Roponen Miranda E. Smith Kathy McKenna Anthony Bosco Lily S. Subrata Emilie Mamessier Matthew E. Wikstr?m Peter Le Souef Peter D. Sly Patrick G. Holt John W. Upham | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 15 | Monitoring of lung volume recruitment and derecruitment using oscillatory mechanics during high-frequency oscillatory ventilation in the preterm lamb 显示文摘 | Pillow JJ Sly PD Hantos Z | 2004 | Pediatr Crit Care Med2004，5，2： | 1 |
| 16 | Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease显示文摘 | Fleming R E Sly W S | 2001 | Proc Natl Acad Sci USA2001，98，15： | 1 |
| 17 | Genetic drift and effective population sizes of hatchery-propagated stocks of the Pacific oyster Crassostrea gigas 显示文摘 | Hedgecock D Sly F | 1990 | Aquaculture1990，88，： | 1 |
| 18 | Virus infection and al lergy in the development of asthma what is the connec tion? 显示文摘 | Holt PG Strickland DH Sly PD | 2012 | Curr Opin Allergy Clin Immunol2012，12，2： | 1 |
| 19 | An unexpected finding late after repair of coarctation of the aorta显示文摘 | Groenemeijer BE Bakker A Slis HW | 2008 | Neth Heart J2008，16，78： | 1 |
| 20 | Salbutamol prevents the increase of respiratory resistance caused by tracheal intubation during sevoflurane anesthesia in asthmatic children 显示文摘 | Scalfaro P Sly PD Sims C | 2001 | Anesth Analg2001，93，4： | 1 |
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