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| 1 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 2 | Hepatocellular carcinoma in Lebanon: Etiology and prognostic factors associated with short-term survival显示文摘瞄准:在黎巴嫩和早死亡预兆的预示的因素学习 HCC 的传染病学。方法:在一个五年的时期上诊断的 HCC 盒子的观察后续队研究被执行。Multivariate 分析被进行与肝意大利的程序(片断) 分数的癌症相比识别预示的因素。包括内在的肝疾病,病人的人口统计的特征,和孩子呸评估的肝疾病的严厉的病原学的多重变量得分被学习。肿瘤参数包括了小瘤,门静脉血栓的存在,和治疗形式的 HCC, alpha-fetoprotein 水平,数字和尺寸的诊断的时间。后续的死亡或损失被看作一个端点事件。结果:92 个病人(平均数 60.5 +/- 22.3 年) 被包括。内在的疾病的病原学分别地是在 67% , 20% ,和 23.5% 的肝炎 B, C,和酒精。在诊断的孩子呸班分别地是在 34.8% , 39.3% 和 25.8% 的 A, B,和 C。全面幸存分别地在 1, 2 和 3 年是 44.8% , 32.8% 和 17.6%( 吝啬的 F/U 40.2 +/- 23.5 瞬间) 。Multivariate 分析识别了早死亡的三个预言者(<
6 瞬间) :胆红素 >
3.2 mg/dL (P <
0.01 ) , HCC 作为肝疾病的第一个演讲(P = 0.035 ) ,并且肌酸酐 >
1 mg/dL (P = 0.017 ) 。一个分数由考克斯基于这些变量超过了片断分数比例的危险。巨鸟曲线显示了两个模型相等、中等精确。结论:HBV 是在黎巴嫩的 HCC 的领先的原因。早死亡的独立预言者是象疾病的第一表明的提高的胆红素,肌酸酐和 HCC。一个分数的未来的确认基于在预言短期的幸存的这些临床的参数被需要。 | César Yaghi Ala I Sharara Paul Rassam Rami Moucari Khalil Honein Joseph BouJaoude Rita Slim Roger Noun Heitham Abdul-Baki Mohamad Khalifeh Sami Ramia Raymond Sayegh | 2006 | World Journal of Gastroenterology2006，12，22： | 3 |
| 3 | Experimental study of the salt gradient solar pond stability 显示文摘 | Karim C Slim Z Kais C | 2010 | Solar Energy2010，84，1： | 1 |
| 4 | Preperative bowd perparaion is it Uesful?显示文摘 | Slim K Flamein R Brugere C | 2004 | J Chir(Paris)2004，141，5： | 1 |
| 5 | Preperative bowd perparaion is it Uesful?显示文摘 | Slim K Flamein R Brugere C | 2004 | J Chir(Paris)2004，141，5： | 1 |
| 6 | Hepatoid adenocarcinoma of the gallbladder显示文摘 | Ellouze S Slim C Ahmad G | 2011 | WorldJ Surg Oncol2011，9，： | 1 |
| 7 | Polyaniline films based ultramicroelectrodes sensitive to pH显示文摘 | SLIM C KTARI N CAKARA D | 2008 | J Electroanal Chem2008，612，： | 1 |
| 8 | Molten fluorides for nuclear applications显示文摘 | Delpech S Cabet C Slim C | 2010 | Materials Today2010，13，5： | 1 |
| 9 | Molten fluorides for nuclear applications显示文摘 | Delpech S Cabet C Slim C | 2010 | Materials Today2010，13，5： | 1 |
| 10 | Comparison of ovine, bovine and porcine mucosal heparins and low molecular weight heparins by disaccharide analyses and 13 C-NMR 显示文摘 | WATTA D K YORKEA S C SLIM G C | 1997 | Carbohydr Polym1997，3，1： | 1 |
| 11 | Sclerosing encapsulating peritonitis:a diagnostic dilemma显示文摘 | Slim R Tohme C Yaghi C | 2005 | J Am Coll Surg2005，200，6： | 1 |
| 12 | Developing a comprehensive understanding and model of hydrate in multiphase flow: From laboratory measurements to field applications显示文摘 | SLIM A K KOH C A SLOAN E D | 2012 | Energy & Fuels2012，26，7： | 1 |
| 13 | Hepatobiliary and Pancreatic: Peliosis hepatis associated with multiple myeloma显示文摘 | R Slim N Hachem V Smayra C Yaghi F Daniel J Boujaoude K Honein R Sayegh M Ghosn | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 14 | Comparative study of the adsorption on chitosan beads of phthalate esters and their degradation products 显示文摘 | Slim C J Liu H Kennedy J F | 2010 | Carbohydrate Polymers2010，81，3： | 1 |
| 15 | Production of mycelia and exo-biopolymer from molasses by Cordyceps sinensis 16 in submerged culture显示文摘 | S H Cha J SLim C S Yoon | 2007 | Bioresource Technology2007，98，： | 1 |
| 16 | Preoperative bowel preparation is it useful?显示文摘 | Slim K Flamein R Brugere C | 2004 | J Chir (Paris)2004，141，5： | 1 |
| 17 | Cooperative diversity for free- space optical communications: transceiver design and performance analysis显示文摘 | Abou-Rjeily C Slim A | 2011 | Communications IEEE Transac- tions on2011，59，3： | 1 |
| 18 | Experimental study of the salt gradient solar pond stability 显示文摘 | Karim C Slim Z Kais C | 2010 | Solar Energy2010，84，1： | 1 |
| 19 | Crab digestive lipase acting at high temperature purification and biochemical characteriza-tion显示文摘 | SLIM C AHMED F I NABIL M | 2007 | Biochimie2007，89，8： | 1 |
| 20 | Approach by localization and multi-objec-tive evolutionary optimization for flexible job'shop schedulingproblems显示文摘 | IMED C SLIM H | 2002 | IEEE?2002，10，9： | 1 |
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