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| 1 | Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease显示文摘AIM:To assess the mucosa-associated bacterial microflora and mucus layer in adolescents with inflammatory bowel disease(IBD) .METHODS:Sixty-one adolescents(mean age 15 years,SD ± 4.13) were included in the study.Intestinal biopsies from inflamed and non-inflamed mucosa of IBD patients and from controls with functional abdominal pain were cultured under aerobic and anaerobic conditions.The number of microbes belonging to the same group was calculated per weight of collected tissue.The mucus thickness in frozen samples was measured under a fluorescent microscope.RESULTS:The ratios of different bacterial groups in inflamed and non-inflamed mucosa of IBD patients and controls were specific for particular diseases.Streptococcus spp.were predominant in the inflamed mucosa of Crohn's disease(CD) patients(80% of all bacteria) ,and Lactobacillus spp.were predominant in ulcerative colitis patients(90%) .The differences were statistically significant(P = 0.01-0.001) .Lower number of bifidobacteria was observed in the whole IBD group.A relation was also found between clinical and endoscopic severity and decreased numbers of Lactobacillus and,to a lesser extent,of Streptococcus in biopsies from CD patients.The mucus layer in the inflamed sites was significantly thinner as compared to controls(P = 0.0033) and to non-inflamed areas in IBD patients(P = 0.031) .CONCLUSION:The significantly thinner mucosa of IBD patients showed a predominance of some aerobes specific for particular diseases,their numbers decreased in relation to higher clinical and endoscopic activity of the disease. | Krzysztof Fyderek Magdalena Strus Kinga Kowalska-Duplaga Tomasz Gosiewski Andrzej Wedrychowicz Urszula Jedynak-Wasowicz Malgorzata Sladek Stanislaw Pieczarkowski Pawel Adamski Piotr Kochan Piotr B Heczko | 2009 | World Journal of Gastroenterology2009，15，42： | 14 |
| 2 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 3 | 三维边界元法中高阶单元上的几乎奇异积分显示文摘三维边界元分析中,高阶几何单元上的几乎奇异积分计算是一个重要而且困难的问题,该文对此进行了研究.使用8节点四边形和6节点三角形曲面单元来描述几何边界;构造了新的距离函数;拓展原有的指数函数非线性变换到三维边界元法中,利用拓展的变换来消除被积函数的几乎奇异性.数值算例表明,该算法稳定,效率高,即使计算点到实际边界的距离很小,依然可获得令人满意的数值解. | 张耀明 李小超 Vladimir Sladek Jan Sladek | 2013 | 力学学报2013，45，6： | 3 |
| 4 | 人类增强的一次热带风暴对近岸珊瑚礁的影响显示文摘土地开发以其造成的土壤加速侵蚀和迁移所产生的水体悬浮物及沉积物而成为人类对珊瑚礁的最主要的威胁。我们研究了一次热带风暴后沉积物对圣卢西亚(St.Lucia)珊瑚礁群落的影响,发现最靠近大的河流河口的珊瑚礁沉积物比较多,珊瑚损失比较大。一些地点的珊瑚死亡率超过了50%,其死亡率和褪色的程度取决于当地的沉积物数量。尽管工程师们努力降低侵蚀率,我们仍然发现风暴来临时正在修建的公路附近的地点有更多的沉积物。我们的资料表明土地开发对珊瑚礁有很大的负效应。假如土地开发的需求不断增加,并且大西洋热带地区大风暴近来频繁,问题可能会进一步加剧。 | Joshua Sladek Nowlis Callum M.Roberts Allan H.Smith Erkki Siirila 裴晓菲 | 1997 | 人类环境杂志1997，26，8： | 2 |
| 5 | A genome-wide association study identifies novel risk loci for type 2 diabetes显示文摘 | Sladek R Rocheleau G Rung J | | 0，，7130： | 1 |
| 6 | Elastic Constants and the Electrical Transition in Ti2O3显示文摘 | CHI T C SLADEK R J | 1973 | Physical Review B1973，7，： | 1 |
| 7 | The effect of AT1 receptor antag oni st on chronic cardiac response to coronary artery ligation in rats显示文摘 | Sladkova J Kolar F | 1996 | Cardiova sc Res1996，31，4： | 1 |
| 8 | A genome-wide association study identifies novel risk loci for type 2 diabetes 显示文摘 | Sladek R Rocheleau G Rung J | 2007 | Nature2007，445，7130： | 1 |
| 9 | Transient heat conduction analysis in functionally graded materials by the meshless local boundary integral equation method显示文摘 | Sladek J Sladek V Zhang C | 2003 | Computational Materials Science2003，28，34： | 1 |
| 10 | A model for diffusion in a glassy polymer显示文摘 | Vieth W R Sladek K J | 1965 | Journal of Colloid Sci1965，20，： | 1 |
| 11 | Microarray analysis of uerine gene expression in mouse and human pregnancy显示文摘 | Bethin K E Nagai Y Sladek R | 2003 | Mol Endocrinnol2003，17，8： | 1 |
| 12 | The loacl boundary integral equation (LBIE) and it's meshless implementation for linear elasticity显示文摘 | Atluri S N Sladek J | 2000 | Comput Mech2000，25，： | 1 |
| 13 | Meshless local Petrov-Galerkin method for heat conduction problem in an anisotropic medium 显示文摘 | Sladek J Sladek V Atluri S N | 2004 | CMES: Computer Modeling in Engineering & Sciences2004，6，3： | 1 |
| 14 | Evaluation of sequential and selective extraction methods for determination of mercury speciation and mobility in m ine waste显示文摘 | SLADEK C GUSTIN M S | | 0，，04： | 1 |
| 15 | Co-grafted embryonic striatum increases the survival of grafted embryonic dopamine neurons显示文摘 | Sortwel CE Col ier TJ Sladek JR Jr | | 0，，04： | 1 |
| 16 | A genome-wide association study identifies novel risk loci for type 2 diabetes 显示文摘 | SLADEK R ROCHELEAU G RUNG J | 2007 | Nature2007，445，7130： | 1 |
| 17 | Inverse heat conduction problems by meshless local Petrov-Galerkin method显示文摘 | Sladek J Sladek V Hon Y C | 2006 | Engineering Analysis with Boundary Elements2006，30，8： | 1 |
| 18 | 显示文摘 | Vohl MC Sladek R Robitaille J | 2004 | Obes Res2004，12，8： | 1 |
| 19 | Diffusion on surface Ⅱ, correlation of diffusivities of physically and chemically adsorbed specie显示文摘 | Sladek K J Gilliland E R Buddour R F | 1974 | Industr Chem fundam1974，13，2： | 1 |
| 20 | A genome-wide association study identifies novel risk loci for type 2 diabetes显示文摘 | SLADEK R ROCI-IELEAU G RUNG J | 2007 | Nature2007，445，2： | 1 |
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