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| 1 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Gastroenterostoma after Billroth antrectomy as a premalignant condition显示文摘Gastric stump carcinoma(GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1 and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be ofspecial interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency. | Robert Sitarz Ryszard Maciejewski Wojciech P Polkowski G Johan A Offerhaus | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Molecular analysis of primary gastric cancer,corresponding xenografts,and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis显示文摘 | Milne AN Sitarz R Carvalho R | 2007 | Hum Pathol2007，38，6： | 1 |
| 4 | Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines显示文摘 | Sitarz R Leguit R J de Leng WW | 2009 | Cell Oncol2009，31，6： | 1 |
| 5 | Identification of silicooxygen rings in SiO2 based on IR spectra显示文摘 | SITARZ M HANDKE M MOZGAWA W | 2000 | Spectrochim Acta A2000，56，9： | 1 |
| 6 | Spectroscopic Studies of Different Aluminosilicate Structures 显示文摘 | W Mozgawa M Sitarz M Rokita | 1999 | Journal of Molecular Structure1999，511，512： | 1 |
| 7 | MFN2 mutations cause compensatory mitochondrial DNA proliferation显示文摘 | Sitarz KS Yu-Wai-Man P Pyle A | | 0，，： | 1 |
| 8 | Molecular analysis of primary gastric cancer,corresponding xenografts,and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis显示文摘 | Milne AN Sitarz R Carvalho R | 2007 | Hum Pathol2007，38，6： | 1 |
| 9 | Identification of silicooxygen rings in SiO2 based on IR spectra显示文摘 | Sitarz M Handke M Mozgawa W | 2000 | Spectrochim Acta A2000，56，9： | 1 |
| 10 | Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines显示文摘 | R. Sitarz R.J. Leguit W.W.J. de Leng F.H.M. Morsink W.P. Polkowski R. Maciejewski G.J.A. Offerhaus A.N. Milne | 2009 | Cellular Oncology2009，，6： | 1 |
| 11 | Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines 显示文摘 | Sitarz R Leguit RJ de Leng WW | 2009 | Cell Onco12009，31，6： | 1 |
| 12 | The COX-2 promoter polymorphism-765G>C is associated with early-onset,conventional and stump gastric cancers显示文摘 | Sitarz R Leguit RJ de Leng WW | 2008 | Mod Pathol2008，21，6： | 1 |
| 13 | Amorphous SiCxOy coat- ings from ladder- like polysilsesquioxanes 显示文摘 | Handke M Sitarz M Dlugon E | 2011 | J Mol Struct2011，993，13： | 1 |
| 14 | IL-1B ?31T>C promoter polymorphism is associated with gastric stump cancer but not with early onset or conventional gastric cancers显示文摘 | R. Sitarz W. W. J. Leng M. Polak F. H. M. Morsink O. Bakker W. P. Polkowski R. Maciejewski G. J. A. Offerhaus A. N. Milne | 2008 | Virchows Archiv2008，，3： | 1 |
| 15 | Ear/y onset gastric cancer: on the road to unraveling gastric carcinogenesis 显示文摘 | Milne AN Sitarz R Carvalho R | 2007 | Curr Mol Med2007，7，1： | 1 |
| 16 | Analysis of Wearwheel-rail interaction using FE software 显示文摘 | Aleksander Sladkowski Marek Sitarz | 2005 | Wear2005，258，： | 1 |
| 17 | Dynamic programming with ordered structures:Theory,examples and applications显示文摘 | Sitarz S | 2010 | Fuzzy Sets and Systems2010，161，20： | 1 |
| 18 | Synthesis of materials from the SiO2 A1PO4-NaCaPO4 system 显示文摘 | M Sitarz W Mozgawa M Rokita | 2001 | CAS2001，66，： | 1 |
| 19 | Analysis of wheel-rail interaction using FE software显示文摘 | Aleksander Sladkowski Marek Sitarz | 2005 | Wear2005，258，78： | 1 |
| 20 | Noncommutative geometry and gauge theory on discrete groups显示文摘 | SITARZ A | 1995 | J Geom Phys1995，15，： | 1 |
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