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| 1 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Gastroenterostoma after Billroth antrectomy as a premalignant condition显示文摘Gastric stump carcinoma(GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1 and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be ofspecial interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency. | Robert Sitarz Ryszard Maciejewski Wojciech P Polkowski G Johan A Offerhaus | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion显示文摘AIM To examine the role that enzyme Acyl-CoA:diacylglycerol acyltransferase-1(DGAT1) plays in postprandial gut peptide secretion and signaling.METHODS The standard experimental paradigm utilized to evaluate the incretin response was a lipid challenge.Following a lipid challenge,plasma was collected via cardiac puncture at each time point from a cohort of 5-8 mice per group from baseline at time zero to 10 h.Incretin hormones [glucagon like peptide-1(GLP-1),peptide tyrosine-tyrosine(PYY) and glucose dependent insulinotropic polypeptide(GIP)] were then quantitated.The impact of pharmacological inhibition of DGAT1 on the incretin effect was evaluated in WT mice.Additionally,a comparison of loss of DGAT1 function either by genetic ablation or pharmacological inhibition.To further elucidate the pathways and mechanisms involved in the incretin response to DGAT1 inhibition,other interventions [inhibitors of dipeptidyl peptidase-IV(sitagliptin),pancreatic lipase(Orlistat),GPR119 knockout mice] were evaluated.RESULTS DGAT1 deficient mice and wildtype C57/BL6J mice werelipid challenged and levels of both active and total GLP-1 in the plasma were increased.This response was further augmented with DGAT1 inhibitor PF-04620110 treated wildtype mice.Furthermore,PF-04620110 was able to dose responsively increase GLP-1 and PYY,but blunt GIP at all doses of PF-04620110 during lipid challenge.Combination treatment of PF-04620110 and Sitagliptin in wildtype mice during a lipid challenge synergistically enhanced postprandial levels of active GLP-1.In contrast,in a combination study with Orlistat,the ability of PF-04620110 to elicit an enhanced incretin response was abrogated.To further explore this observation,GPR119 knockout mice were evaluated.In response to a lipid challenge,GPR119 knockout mice exhibited no increase in active or total GLP-1 and PYY.However,PF-04620110 was able to increase total GLP-1 and PYY in GPR119 knockout mice as compared to vehicle treated wildtype mice.CONCLUSION Collectively,these data provide some insight into the mechanism by which inhibition of DGAT1 enhances intestinal hormone release. | Benjamin S Maciejewski Tara B Manion Claire M Steppan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，4： | 2 |
| 4 | EasySVM: A visual analysis approach for open-box support vector machines显示文摘Support vector machines(SVMs) are supervised learning models traditionally employed for classification and regression analysis. In classification analysis, a set of training data is chosen, and each instance in the training data is assigned a categorical class. An SVM then constructs a model based on a separating plane that maximizes the margin between different classes. Despite being one of the most popular classification models because of its strong performance empirically, understanding the knowledge captured in an SVM remains difficult. SVMs are typically applied in a black-box manner where the details of parameter tuning, training, and even the final constructed model are hidden from the users. This is natural since these details are often complex and difficult to understand without proper visualization tools. However, such an approach often brings about various problems including trial-and-error tuning and suspicious users who are forced to trust these models blindly.The contribution of this paper is a visual analysis approach for building SVMs in an open-box manner.Our goal is to improve an analyst's understanding of the SVM modeling process through a suite of visualization techniques that allow users to have full interactive visual control over the entire SVM training process.Our visual exploration tools have been developed to enable intuitive parameter tuning, training datamanipulation, and rule extraction as part of the SVM training process. To demonstrate the efficacy of our approach, we conduct a case study using a real-world robot control dataset. | Yuxin Ma Wei Chen Xiaohong Ma Jiayi Xu Xinxin Huang Ross Maciejewski Anthony K.H.Tung | 2017 | Computational Visual Media2017，3，2： | 2 |
| 5 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 6 | Computational Modeling for the Computer Animation of Legged Figures显示文摘 | Girard and Maciejewski | 1985 | Computer Graphics1985，19，3： | 2 |
| 7 | Increased expression of Fas antigen on bone marrow CD+34 cells of patients with aplastic anaemia显示文摘 | Maciejewski J P Selleri C Sato T | | 0，，： | 2 |
| 8 | Fas antigen expression on CD34+human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro显示文摘 | Maciejewski J Selleri C Anderson S | 1995 | Blood1995，85，11： | 2 |
| 9 | Fas antigen expression on CD 34+human marrow cells is induced by interferon-gammasu-pression in vitro 显示文摘 | Maciejewski JP Selleri C young NS | 1995 | Blood1995，85，11： | 1 |
| 10 | The hazard of accele-rated tumor clonogen repopulation during radiotherapy显示文摘 | Taylor JM Maciejewski B | 1988 | Acta Oncologica1988，279，2： | 1 |
| 11 | Human cytomegalovirus persists in myeloid progenitors and is passed to the myeloid progeny in a latent form 显示文摘 | Khaiboullina SF Maciejewski JP Crapnell K | 2004 | Br J Haemoto12004，126，3： | 1 |
| 12 | The hazard of accelerated tumor clonogen repopulation during radiotherapy 显示文摘 | Withers HR JMC Maciejewski B | 1989 | Acta Oncol1989，27，： | 1 |
| 13 | Bone marrow and peripheral blood lymphocyte henotype in patients with bone marrow failure显示文摘 | Maciejewski JP Hibbs JR Anderson S | 1994 | Exp Hematol1994，22，： | 1 |
| 14 | On algebraic non- integrability of the Halphen system显示文摘 | Maciejewski A J Strelcyn J M | 1995 | Phys Lett1995，201，： | 1 |
| 15 | Fas-mediated modulation of Bcr/abl in chronic myelogenous leukemia results in differetial effects on apoptosis显示文摘 | Maciejewski JP Pane F | 1998 | Blood1998，92，： | 1 |
| 16 | Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones显示文摘 | Maciejewski JP Rivera C Kook H | 2001 | Br J Haematol2001，115，4： | 1 |
| 17 | Case report of schwannoma of the rectum-clinical and pathological contribution显示文摘 | Maciejewski A Lange D Wloch J | 2000 | Med Sci Monit2000，6，4： | 1 |
| 18 | Fault tolerant operation of kinematically redundant manipulators for locked joint failures显示文摘 | Lewis L Maciejewski A | 1997 | IEEE Transaction on Robotics and Automation1997，13，4： | 1 |
| 19 | Intracellular interferongamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia显示文摘 | Sloand E Kim S Maciejewski J P | 2002 | Blood2002，100，4： | 1 |
| 20 | Stresful life events interacting with cognitive/personaliy styles to predict late-onset major depression显示文摘 | Mazuer CM Maciejewski PK Jacobs SC | 2002 | Am J Geriatr Psychiatry2002，10，： | 1 |
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