|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet显示文摘AIM: To determine the fasting plasma carnitine ester in patients with celiac disease.METHODS: We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet.RESULIS: The level of free camitine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced (4.703 ± 0.205 vs 10.227 ± 0.368 nmol/mL,P<0.01). The level of propionylcarnitine was 61.5%,butyrylcarnitine 56.9%, hexanoylcarnitine 75%,octanoylcarnitine 71.1%, octenoylcarnitine 52.1%,decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%,lauroylcarnitine 61.5%, miristoylcarnitine 66.7%,miristoleylcarnitine 62.5% and oleylcarnitine 81.1%in the celiac disease patients compared to the control values, respectively (P<0.01).CONCLUSION: The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis. | Judit Bene Katalin Komlósi Beáta Gasztonyi Márk Juhász Zsolt Tulassay Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，42： | 5 |
| 3 | 严重凝血病患者输注新鲜冰冻血浆的研究显示文摘临床实验资料显示尽管限制红细胞输注策略的临床效果等同或高于随意进行红细胞输注的效果,但这些资料很少涉及到新鲜冰冻血浆(FFP)的应用。目前,临床大部分FFP的应用,即便是那些《实践指导》所推荐的有关FFP的应用均缺乏临床随机实验结论的支持。除个别文献证实FFP输注的疗效外,FFP输后均有着明显的不良反应,如输血相关的急性肺损伤、输血相关的循环超负荷和过敏反应等。 | Dara SI Rana R Afessa B 许飞(节译) 陈会友(审校) 田兆嵩(审校) | 2007 | 国际输血及血液学杂志2007，30，4： | 4 |
| 4 | Realization of laser textured brass surface via temperature tuning for surface wettability transition显示文摘Superhydrophobic surfaces have attracted extensive interests and researches into their fundamentals and potential applications.Laser texturing provides the convenience to fabricate the hierarchical micro/nanostructures for superhydrophobicity.However,after laser texturing,long wettability transition time from superhydrophilicity to superhydrophobicity is a barrier to mass production and practical industrial applications.External stimuli have been applied to change the surface composition and/or the surface morphology to reduce wettability transition time.Herein,by temperature tuning,wettability transition of laser textured brass surfaces is investigated.Scanning electron microscopy and surface contact angle measurement are employed to characterize the surface morphology and wettability behavior of the textured brass surfaces.By low-temperature heating(100℃~150℃),partial deoxidation of the top Cu O layer occurs to form hydrophobic Cu_2O.Therefore,superhydrophobicity without any chemical coating and surface modification could be achieved in a short time.Furthermore,after low-temperature heating,the low adhesive force between the water droplet and the sample surface is demonstrated for the laser textured brass surface.This study provides a simple method to fabricate the micro/nanostructure surfaces with controllable wettability for the potential applications. | Huangping Yan Mohamed Raiz B Abdul Rashid Si Ying Khew Fengping Li Minghui Hong | 2017 | 光电工程2017，44，6： | 2 |
| 5 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 6 | Global exponential stability of neural networks with globally Lipschitz continuous activations and its application to linear variational inequality problem显示文摘 | Liang X B Si J | 2001 | IEEE Trans Neural Networks2001，12，2： | 1 |
| 7 | Nitrogen, sulfur, and chlorine trans- formations during the pyrolysis of straw显示文摘 | Wang X B Si J P Tan H Z | 2010 | Energy & Fuels2010，24，9： | 1 |
| 8 | Holocene climate changes in the monsoon/arid transition reflected by carbon concentration in Daihai Lake of Inner Mongolia显示文摘 | XIAOJ L WU J T SI B | | 0，，04： | 1 |
| 9 | Dye Congo Red adsorptive decolorization by adsorbents obtained fi'om Trametes pubescer pellets显示文摘 | Si J Cui B K | 2013 | Desalination and Water Treatment2013，51，： | 1 |
| 10 | Determi?nation of tetracyclines in pig and other meat samples using liquid chromatography coupled with diode array and tandem mass spectrometric detectors显示文摘 | T?lgyesi áá T?lgyesi L Békési K | 2014 | Meat Sci2014，96，13： | 1 |
| 11 | Monoatomic Layer Removal Mechanism in Chemical Mechanical Polis- hing Process: A Molecular Dynamics Study显示文摘 | Si L N Guo D Luo J B | 2010 | Journal of Applied Physics2010，107，6： | 1 |
| 12 | Identifying product failure rate based on a conditional Bayesian network classifier显示文摘 | Cai Z Q Sun S D Si S B | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 13 | Management of venous thromboembolism in patients with advanced cancer:a systematic review and meta-analysis显示文摘 | Noble SI Shelley MD Coles B | 2008 | Lancet Oncol2008，9，： | 1 |
| 14 | Numerical simulationof the NOx emissions in a 1,000,MW tangentially firedpulverized-coal boiler:Influence of the multi-group arrangementof the separated over fire air 显示文摘 | Zhou H Mo G Y Si D B | 2011 | Energy &Fuels2011，25，5： | 1 |
| 15 | Genetic studies of body mass indexyield new insights for obesity biology 显示文摘 | Locke AE Kahali B Bemdt SI | 2015 | Nature2015，518，7538： | 1 |
| 16 | 查看详情显示文摘 | Bhugwant C Siéja B Bessafi M | | 0，，： | 1 |
| 17 | On the dynamic evidential reasoning algorithm for fault prediction 显示文摘 | Si X S Hu C H Yang J B | 2011 | Expert Systems with Applications2011，38，5： | 1 |
| 18 | The inflammatory properties of contained and noncontained lumbar disc henniation显示文摘 | Nygaard OP Mellgren SI Osterud B | 1997 | Spine (Phila Pa 1976)1997，22，21： | 1 |
| 19 | Statins induce the regression of left ventricular mass in patients with angina显示文摘 | Nishikawa H Miura SI Zhang B | 2004 | Circ J2004，68，： | 1 |
| 20 | Scales and locations of time stability of soil water storage in a hummocky landscape显示文摘 | Biswas A Si B C | 2011 | Journal of Hydrology2011，408，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员