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| 1 | Clinical characteristics and outcome of hepatocellular carcinoma in alcohol related and cryptogenic cirrhosis: a prospective study显示文摘BACKGROUND: Non-alcoholic fatty liver disease(NAFLD) is becoming a leading cause of chronic liver disease. Hepatocellular carcinoma(HCC) is one of its complications. Although the pathophysiology is unclear, it is reasonable to expect that cryptogenic cirrhosis related HCC(cryptogenic HCC) behaves differently to other types of HCC. This study prospectively compared patients with cryptogenic HCC and those with HCC related to alcoholic cirrhosis. METHODS: A total of 150 consecutive patients with HCC(89 cryptogenic HCC and 61 alcohol related HCC) referred to our unit over a 23-month period were studied. Their demographic data, liver function, tumor characteristics and outcomes were compared.RESULTS: Alcohol related HCC was seen only in males. Compared with cryptogenic HCC, alcohol related HCC had significantly higher aspartate aminotransferase/alanine aminotransferase(AST/ALT) ratio(1.7 vs 1.4, P=0.002), model for endstage liver disease score(13 vs 11, P=0.018) and Child's score(7 vs 6, P=0.037). No significant difference was seen in platelet counts, serum sodium and AST to platelet ratio index. Single nodular tumors were more common in cryptogenic HCC,while diffuse type tumors and macroscopic vascular invasion were common in alcohol related HCC. In patients who could not be offered any treatment because of advanced tumors or poor liver function, alcohol related HCC had a significantly lower median survival(5.3 months) compared with cryptogenic HCC(9.3 months, P=0.034).CONCLUSIONS: Compared with cryptogenic HCC, alcohol related HCC had worse liver function and aggressive tumor morphology at presentation, and a higher proportion was untreatable. In patients who could not be treated, median survival was lower in patients with alcohol related HCC than in those with cryptogenic HCC. | Rohan C Siriwardana Maduni A Niriella Anuradha S Dassanayake Chandika Liyanage Bhagya Gunathilaka Subani Jayathunge Hithanadura J de Silva | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 5 |
| 2 | Mild ERCP-induced and non-ERCP-related acute pancreatitis: two distinct clinical entities?显示文摘 | Ghalib H. Abid H. Priyantha Siriwardana Adrian Holt Basil J. Ammori | 2007 | Journal of Gastroenterology2007，，2： | 2 |
| 3 | Endoscopic mucosal resection of a solitary metastatic tumor in the stomach: a case report显示文摘 | Siriwardana H P Harvey M H Kadirkamanathan S S | 2012 | Surg Laparosc Endosc Percutan Tech2012，22，3： | 1 |
| 4 | Autocrine/ paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase显示文摘 | Siriwardana G Bradford A Coy D | 2006 | Mol Endocrinol2006，20，9： | 1 |
| 5 | CyclinD1 overexperssion VS retin oblastoma inactivation: implications for growth control evasion in non- small cell and small cell lung cancer显示文摘 | Siriwardana Langan TA | 1994 | Proc Natl Acod Sci USA1994，91，16： | 1 |
| 6 | Identifiea tion and characterization of NF-Y transcription factor fami lies in the monoeot model plant Brachypodium distachyon 显示文摘 | Cao S H Kumimoto R W Siriwardana C L | 2011 | PLoS One2011，6，21： | 1 |
| 7 | Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer显示文摘 | Siriwardana HP Siriwardena AK | 2006 | Br J Surg2006，93，6： | 1 |
| 8 | The Australia-United States Free Trade Agreement: An economic evaluation显示文摘 | Mahinda Siriwardana | 2006 | North American Journal of Economics and Finance2006，，1： | 1 |
| 9 | Role of portal vein embolization in hepatocellular carcinoma management and its effect on recurrence: a case-control study 显示文摘 | Siriwardana RC Lo CM Chan SC | 2012 | World J Surg2012，36，7： | 1 |
| 10 | Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pan- createctomy for cancer显示文摘 | Siriwardana HPP Siriwardena AK | 2006 | Br J Surg2006，93，6： | 1 |
| 11 | Mild ERCP-induced and non-ERCP-related acute pancreatitis: two distinct clinical entities?显示文摘 | Ghalib H. Abid H. Priyantha Siriwardana Adrian Holt Basil J. Ammori | 2007 | Journal of Gastroenterology2007，，2： | 1 |
| 12 | Systematic appraisal of the role of metallic endobiliary stents in the treatment of benign bile duct stricture显示文摘 | Siriwardana H P Siriwardena A K | 2005 | Ann Surg2005，242，： | 1 |
| 13 | Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasinghormone via Ras, Raf, and mitogen-activated protein kinase显示文摘 | SIRIWARDANA G BRADFORD A COY D | 2006 | Mol Endocrinol2006，20，9： | 1 |
| 14 | Role of portal vein em- bolization in hepatocellular carcinoma management and its effect on recurrence: a case-control study显示文摘 | Siriwardana RC Lo CM Chan SC | 2012 | World J Surg2012，36，7： | 1 |
| 15 | Minimizing the thermal impact of computing equipment upgrades in data centers显示文摘 | Jayantha Siriwardana Saman K Halgamuge Thomas Scherer | 2012 | Energy and Buildings2012，50，7： | 1 |
| 16 | Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer显示文摘 | Siriwardana HP Siriwardena AK | 2006 | Br J Surg2006，93，6： | 1 |
| 17 | Systematic appraisal of the role of metallic endobiliary stents in the treatment of benign bile duct stricture显示文摘 | Siriwardana HP Siriwardena AK | 2005 | Ann Surg2005，242，1： | 1 |
| 18 | The australia - United States free trade agreement: an economic evaluation 显示文摘 | Siriwardana M | 2007 | The North American Journal of Economics and Finance2007，18，1： | 1 |
| 19 | The Environmental and Economic Impact of the Carbon Tax in Australia 显示文摘 | MENG S SIRIWARDANA M MCNEILL J | 2013 | Environ- mental and Resource Economics2013，，： | 1 |
| 20 | Synthesis of pyridinylpyrrole derivatives via the palladium-catalyzed reaction of acetylpyridines with methyleneaziridines显示文摘 | SIRIWARDANA A 1 GRIDNEV I D YAM-AMOTO | | 0，，： | 1 |
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