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| 1 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 2 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 3 | Imaging of gaucher disease显示文摘Gaucher disease is the prototypical lysosomal storage disease.It results from the accumulation of undegrad-ed glucosylceramide in the reticuloendothelial system of the bone marrow,spleen and liver due to deficiency of the enzyme glucocerebrosidase.This leads to he-matologic,visceral and skeletal maifestions.Build up of glucosylceramide in the liver and spleen results in hepatosplenomegaly.The normal bone marrow is re-placed by the accumulating substrate leading to many of the hematologic signs including anemia.The visceral and skeletal manifestations can be visualized with vari-ous imaging modalities including radiography,com-puted tomography,magnetic resonance imaging(MRI)and radionuclide scanning.Prior to the development of enzyme replacement therapy,treatment was only sup-portive.However,once intravenous enzyme replace-ment therapy became available in the 1990s it quickly became the standard of care.Enzyme replacement therapy leads to improvement in all manifestations.Thevisceral and hematologic manifestations respond more quickly usually within a few months or years.The skel-etal manifestations take much longer,usually several years,to show improvement.In recent years newer treatment strategies,such as substrate reduction thera-py,have been under investigation.Imaging plays a key role in both initial diagnosis and routine monitoring of patient on treatment particularly volumetric MRI of the liver and spleen and MRI of the femora for evaluating bone marrow disease burden. | William L Simpson George Hermann Manisha Balwani | 2014 | World Journal of Radiology2014，6，9： | 3 |
| 4 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 5 | Chronic nitrogen enrichment affects the structure and function of the soil microbial community in temperate hardwood and pine forests显示文摘 | Serita D Frey Melissa Knorr Jeri L Parrent Rodney T Simpson | 2004 | Forest Ecology and Management2004，，1： | 2 |
| 6 | Racial differences in effectiveness of α-fetoprotein for diagnosis of hepatocellular carcinoma in hepatitis C virus cirrhosis显示文摘 | Mindie H Nguyen Ruel T Garcia Peter W Simpson Teresa L Wright Emmet B Keeffe | 2002 | Hepatology2002，，2： | 2 |
| 7 | Satellite detection of natural hydrocarbon seepage: Palm Valley gas field, Amadeus Basin, Central Australia显示文摘 | Simpson C J Wilford J R Macials L F | 1989 | The APEA Journal1989，29，： | 1 |
| 8 | The cancer/testis genes:review,standardization,and commentary显示文摘 | Simpson A J Old L J | 2004 | Cancer Immunity2004，4，： | 1 |
| 9 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 10 | The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene显示文摘 | LI J SIMPSON L TAKAHASHI M | 1998 | Cancer Res1998，58，29： | 1 |
| 11 | Junction flows显示文摘 | Simpson R L | 2001 | Annual Review of Fluid Mechanics2001，33，1： | 1 |
| 12 | Isolation and identification of 2 - methoxy - 3,5 - dimethyrazine, a potent musty compound from wine corks 显示文摘 | Robert F Simpson Dimitra L Capone Mark A Sefton | 2004 | J Agric Food of Chem2004，52，： | 1 |
| 13 | A micmRNA upregulated in asthma airway T cells promotes TH2 cytokine production显示文摘 | Simpson L J Patel S Bhakta N R | 2014 | Nat Immunol2014，15，12： | 1 |
| 14 | The opera- tive treatment of scapular fracture 显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | J Bone joint Surg Br1984，66，： | 1 |
| 15 | Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought responsive Cis-element in the EARLY RESPONSIVE TO DEHYDRATION STRESS promoter显示文摘 | TRAN L NAKASHIMA K SAKUMA Y SIMPSON S D FUJITA Y MARUYAMA K FUJITA M SEKI M SHINOZAKI K YAMAGUCHI-SHINOZAKI K | 2004 | The Plant Cell2004，16，9： | 1 |
| 16 | The operative treatment of scapular fractures 显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | J Bone Joint Surg (Br)1984，66，7： | 1 |
| 17 | The disk loaded monopole antenna显示文摘 | SIMPSON Ted L | | 0，，02： | 1 |
| 18 | Contrala- teral stimulation,using TENS,of phantom limb pain: two con- firmatory cases显示文摘 | GIUFFRIDA O SIMPSON L HALLIGAN P W | 2010 | Pain Med2010，11，1： | 1 |
| 19 | Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR 显示文摘 | SMITH J L RANGARAJ K SIMPSON R | 2004 | J Lipid Res2004，45，4： | 1 |
| 20 | 显示文摘 | Simpson SH Gamble JM Mereu L etal Effect of aspirin does on mortality and cardiovascular events in people with diabetes:a meta- analysis | 2011 | J Gen Inter Med2011，26，11： | 1 |
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