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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 3 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 4 | Liver Planning Software Accurately Predicts Postoperative Liver Volume and Measures Early Regeneration显示文摘 | Amber L. Simpson David A. Geller Alan W. Hemming William R. Jarnagin Logan W. Clements Michael I. D’Angelica Prashanth Dumpuri Mithat G?nen Ivan Zendejas Michael I. Miga James D. Stefansic | 2014 | Journal of the American College of Surgeons2014，，： | 2 |
| 5 | Electrospinning of collagen nanofibers 显示文摘 | Matthews J A Wnek G E Simpson D G | 2002 | Biomacromolecules2002，3，2： | 1 |
| 6 | Cooling and steam conditioning after high-temperature drying of Pinuz radiata board: Experimental investigation and mathematical modelling显示文摘 | PANG Shu-sheng SIMPSON I G HASLETr A N | 2001 | Wood Science and Technology2001，，35： | 1 |
| 7 | Interactive venation-based leaf shape modeling显示文摘 | Sung Min Hong Bruce Simpson Gladimir V G Baranoski | 2005 | Computer Animation and Virtual Worlds2005，16，34： | 1 |
| 8 | Aromatase eytochrome 17450, the enzyme resporsible for estrogen biosynthesis 显示文摘 | Simpson E R Mahendroo M S Means G D | 1994 | Endocrinol Rev1994，15，： | 1 |
| 9 | Reducing the number of unknowns in a constrained minimization problem-an applicationto material balances显示文摘 | Simpson D E Everett M G | 1988 | Appl Math Modelling1988，，： | 1 |
| 10 | Rapid silver staining and recover of PCR products separated in polyacrylamide gels显示文摘 | SANGUINETTI C J DIAS N E SIMPSON A J G | 1994 | Bio techniques1994，17，： | 1 |
| 11 | A proposed Tropical Rainfall Measuring Mission (TRMM) satellite显示文摘 | SIMPSON J ADLER R F NORTH G R | 1988 | Bull Amer Meteor Soc1988，69，3： | 1 |
| 12 | Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia显示文摘 | Kramer M Simpson G Maciulis V | 2007 | J Clin Psycho- pharmacol2007，27，： | 1 |
| 13 | Adherenee of eoagulase- negative staphylococci to plastic tissue culture plates:a quantitative model for the adherence of staphylococci to medical devices 显示文摘 | Christensen G D Simpson W A Younger J J | 1985 | Journal Clinical Microbiology1985，22，6： | 1 |
| 14 | Variations in methane and nitrous oxide mixing ratios at the southern boundary of a Canadian boreal forest 显示文摘 | Simpson I J Edwards G C Thurtell G W | 1999 | Atmospheric Environment1999，33，7： | 1 |
| 15 | Differences in DNA methylation patterns are detectable during the di- morphic transition of fungi by amplification of restriction polymorphisms 显示文摘 | Reyna-Lopez G E Simpson J Ruiz-Herrera J | 1997 | Mol Gen Genet1997，253，： | 1 |
| 16 | Denaturing gradientgeI electrophoresis analysis of 16S ribosomal DNA applicants to monitor changes in fecal bacterial populations of weaning pigs after introduction of Lactobacillus reuteri strain MM53显示文摘 | Simpson JM McCracken VJ G askins HR | 2000 | Appl Environ Microbial2000，66，11： | 1 |
| 17 | Board structure, ownership,and financial distress in banking firms 显示文摘 | SIMPSON W G GLEASON A E | 1999 | International Review of Economies and Finance1999，8，3： | 1 |
| 18 | A rating scale for tardive dyskinesia显示文摘 | Lee J H Zoubok B | 1979 | Psychopharmacology (Berl)1979，64，17： | 1 |
| 19 | Source apportionment of visibility degradation problems in Brisbane (Australia) using the multiple linear regression techniques显示文摘 | Chun Y C Simpson R W Mctainsh G H | 1999 | J Atmospheric Environment1999，33，19： | 1 |
| 20 | The opera- tive treatment of scapular fracture 显示文摘 | Hardegger F H Simpson L A Weber B G | 1984 | J Bone joint Surg Br1984，66，： | 1 |
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