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| 1 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 2 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 3 | Paracellin-1, a renal tight junction protein required for paracellular Mg^2+ resorption 显示文摘 | Simon D B Lu Y Choate K A | 1999 | Science1999，285，5424： | 1 |
| 4 | Neurobehavioral function and tibial and chelatable lead levels in 543 former organo lead workers显示文摘 | STEWART W F SCHWARIZ B S SIMON D | 1999 | Neurology1999，52，： | 1 |
| 5 | Sediment transport capacity of overland flow 显示文摘 | Julien P Y Simons D B | 1985 | Transaction of the ASAE1985，28，3： | 1 |
| 6 | Open systems: panoramic views of gene expression 显示文摘 | Green C D Simons J F Taillon B E | 2001 | Journal of Immunological Methods2001，250，12： | 1 |
| 7 | An analytical solution for the transient response of saturated porous elastic solids显示文摘 | SIMON B R ZIENKIEWICZ O C PAUL D K | 1984 | International Journal for Numerical and Analytical Methods in Geomechanics1984，8，： | 1 |
| 8 | Error Analysis of Continuous GPS Position Time Series 显示文摘 | SIMON W D P YEHUDA B PENG F | 2004 | JGR2004，109，03： | 1 |
| 9 | Gitelman s variant of Bartter s syndrome, inherited hypokalaemie alkalosis, is caused by mutations in the hiazide-sensitive Na-C1 eotransporter显示文摘 | Simon D B Nelson-Williams C Bia M J | 1996 | Nat Genet1996，12，： | 1 |
| 10 | High free fatty acid concentration:an independent risk factor for hypertension in the Paris Prospective Study显示文摘 | Balkau B Simon D | 1998 | Int J Epidemiol1998，27，： | 1 |
| 11 | Microlens arrays on large area UV transparent hybrid sol-gel materials for ooticaltools 显示文摘 | SIMONE D Z GIOIA D G GIOVANNA B | 2010 | Microelectron|c Engineering(S0167-9317)2010，87，58： | 1 |
| 12 | Sediment transport capacity of o- verland flow显示文摘 | ULIEN P Y SIMONS D B | 1985 | Trans ASAE1985，28，3： | 1 |
| 13 | Open access publishing, article downloads and citations : Randomised trial 显示文摘 | Davis P M Lewenstein B V Simon D H ct al | 2008 | BMJ2008，337，7： | 1 |
| 14 | Ecosystem response to antibiotics entering the aquatic environment 显示文摘 | Simon D C John M John B | 2005 | Marine Pollution Bulle- tin2005，51，： | 1 |
| 15 | Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets 显示文摘 | James B Steven T Janet D Simon J Dunmore | 2002 | FEBS Letters2002，513，： | 1 |
| 16 | A QTL affecting milk yield and composition maps to bovine chromosome 20: A confirmation 显示文摘 | Arranz J J Coppieters W Berzi P Cambisano N Grisart B Karim L Marcq F Moreau L Mezer C Riquet J Simon P Vanmanshoven P Wagenaar D and Georges M | 1998 | Animal Genetics1998，29，： | 1 |
| 17 | Counterion effects on hexadecyltrimethylammonium surfactant adsorption and self- assembly on silica显示文摘 | Velegol Stephanie B Fleming Barry D Biggs Simon | 2000 | Langmuir2000，16，6： | 1 |
| 18 | Meeting the current challenge of designing high capability SSKS 显示文摘 | SIMON D B | 2008 | BMT'' s new SSK Design2008，，6： | 1 |
| 19 | Using next-generation sequencing approaches to isolate simple sequence repeat (SSR) loci in the plant sci- ences显示文摘 | Zalapa JE Cuevas H Zhu HY Steffan S Senalik D Zeldin E McCown B Harbut R Simon P | 2012 | Am J Bet2012，99，2： | 1 |
| 20 | Stress recovery during exposure to natural and urban environments显示文摘 | ULRICH R S SIMONS R F LOSITO B D | 1991 | Journal of Environmental Psychology1991，11，3： | 1 |
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