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| 1 | Preoperative selection of patients with colorectal cancerliver metastasis for hepatic resection显示文摘Surgical resection of colorectal liver metastases(CRLM) has a well-documented improvement in survival. To benefit from this intervention, proper selection of patients who would be adequate surgical candidates becomes vital. A combination of imaging techniques may be utilized in the detection of the lesions. The criteria for resection are continuously evolving; currently, the requirements that need be met to undergo resection of CRLM are: the anticipation of attaining a negative margin(R0 resection), whilst maintaining an adequate functioning future liver remnant. The timing of hepatectomy in regards to resection of the primary remains controversial; before, after, or simultaneously. This depends mainly on the tumor burden and symptoms from the primary tumor. The role of chemotherapy differs according to the resectability of the liver lesion(s); no evidence of improved survival was shown in patients with resectable disease who received preoperative chemotherapy. Presence of extrahepatic disease in itself is no longer considered a reason to preclude patients from resection of their CRLM, providing limited extra-hepatic disease, although this currently is an area of active investigations. In conclusion, we review the indications, the adequate selection of patients and perioperative factors to be considered for resection of colorectal liver metastasis. | Rafif E Mattar Faisal A Al-alem Eve Simoneau Mazen Hassanain | 2016 | World Journal of Gastroenterology2016，22，2： | 13 |
| 2 | Portal vein embolization effect on colorectal cancer liver metastasis progression:Lessons learned显示文摘Colorectal liver metastasis(CRLM) is the major cause of death in patients diagnosed with colorectal cancer. The gold standard treatment of CRLM is surgical rese-ction. Yet, in the past, more than half of these patients were deemed unresectable due to the inadequate future liver remnant(FLR). The introduction of efficient portal vein embolization(PVE) preoperatively allowed more resections of metastasis in CRLM patients by stimulating adequate liver hypertrophy. However, several exp-erimental and clinical studies reported tumor progression after PVE which critically influences the subsequent management of these patients. The underlying path-ophysiological mechanism of tumor progression post-PVE is still not fully understood. In spite of the adverse effects of PVE, it remains a potentially curative procedure in patients who would remain otherwise unresectable because of the insufficient FLR. Currently, the challenge is to halt tumor proliferation following PVE in patients who require this technique. This could potentially be achieved by either attempting to suppress the underlying oncologic stimulus or by inhibiting tumor growth once observed after PVE, without jeopardizing liver regeneration. More research is still required to better identify patients at risk of experiencing tumor growth post-PVE. | Eman Al-Sharif Eve Simoneau Mazen Hassanain | 2015 | World Journal of Clinical Oncology2015，6，5： | 7 |
| 3 | Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: Results of the CAP (Comparative Atorvastatin Pleiotropic effects) study显示文摘 | Jacques Bonnet R. McPherson A. Tedgui D. Simoneau A. Nozza P. Martineau Jean Davignon | 2008 | Clinical Therapeutics2008，，： | 3 |
| 4 | Applications of large eddy simulations in nuclear field显示文摘 | SIMONEAU J P CHAMPIGNY J GELINEAU O | 2010 | Nuclear Engineering and Design2010，240，2： | 1 |
| 5 | Genetics of aerobic and anaerobic performances显示文摘 | Bouchard C Dionne FT Simoneau JA | 1992 | Exerc Sport Sci Rev1992，20，： | 1 |
| 6 | Moderate hypobaric hypoxia used as an inducer of congenital vertebral malformation in mouse embryo显示文摘 | Rivard CH Labelle P Simoneau R | 1982 | Chir Pediatr1982，23，： | 1 |
| 7 | Attentional demands for postural control: the effects of aging and sensory reintegration显示文摘 | N Teasdale M Simoneau | 2001 | Gait & Posture2001，，3： | 1 |
| 8 | The capacity of nondigestible carbohydrates to stimulate fecal bifid bacteria in healthy humans: a douhle-hlind, randomized, placebo-eont rolled, parallel-group, dose-responder elation study显示文摘 | Bouhnik Y Raskine L Simoneau G | 2004 | A- merican Journal of Clinical Nutrition2004，80，6： | 1 |
| 9 | Muscle fiber area distribution of musculus uvulae in obstructive sleep apnea and non-apneic snorers显示文摘 | SEARIEAS F SIMONEAU J ST PIERRE S | 2000 | Int J Obesity2000，24，： | 1 |
| 10 | Stability Testing of Selected Plastics Additives for Food Contact in EU Aqueous,Fatty and Alternative Simulants显示文摘 | SIMONEAU C HANNAERT P | 1998 | Food Addit Contam1998，16，5： | 1 |
| 11 | Muscle-specific creatine kinase gene polymorphism and VO2max in the HERITAGE Family Study显示文摘 | Rivera MA Dionne FT Simoneau JA | 1997 | 1ed Sci Sports Exerc1997，29，10： | 1 |
| 12 | Foot and ankle sensory neuropathy,proprioception,and postural stability 显示文摘 | van Deursen RW Simoneau GG | 1999 | J Orthop Sports Phys Ther1999，29，12： | 1 |
| 13 | Analytical screening of polyadipates and other plasticisers in poly(vinyl chloride) gasket seals and in fatty food by gas chromatography–mass spectrometry显示文摘 | Z. E?erskis V. Morkūnas M. Suman C. Simoneau | 2007 | Analytica Chimica Acta2007，，1： | 1 |
| 14 | Fish growth rates modulate mercury concentrations in walleye (Sander vitreus) from eastern Canadian lakes显示文摘 | Simoneau M Lueotte M Garceau S | 2005 | Environmental Research2005，98，1： | 1 |
| 15 | D-dimer can predict survival in patients with chronic atrial fibrillation 显示文摘 | Mahe I Drouet L Simoneau G | 2004 | Blood Coagul Fibrinolysis2004，15，5： | 1 |
| 16 | In vitro and prion protein oligomers 显示文摘 | Simoneau S Rezaei H in vivo neurotoxicity of Sale s N | 2007 | PLoS Pathogens2007，，3： | 1 |
| 17 | Reponses of Maximal Aerobic Power and Capacity to Aerobic Training显示文摘 | LORTIE G SIMONEAU J A HAMEL P | 1984 | Int J Spots Med1984，，5： | 1 |
| 18 | Electrochemical study of Li4Ti5O12 as negative electrode for Li-ion polymer rechargeable batteries显示文摘 | ZAGHIB K SIMONEAU M ARMAND M GAUTHIER M | 1999 | Journal of Power Source1999，81，： | 1 |
| 19 | Electrochemical Study of Li4 Ti5 O12 as Negative Electrode for Li-Ion Polymer Rechargeable Batteries显示文摘 | ZAGHIB K SIMONEAU M ARMAND M | | 0，，： | 1 |
| 20 | The PATCHED/ Sonic Hedgehog signalling pathway in superficial bladder cancer 显示文摘 | LaRue H Simoneau M Aboulkassim TO | 2003 | ned Sci (Paris)2003，19，10： | 1 |
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