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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Genetic contribution of the endothelial constitutive nitric oxide snythase gene to plasma nitric oxide levels显示文摘 | Mahaney MC Sim AS | 1997 | Arterioscler Thromb Vasc Biol1997，17，11： | 1 |
| 3 | Distribution in Healthy and Coronary Populations of the Methylenetetrahydrofolate Reductase(MTHFR) C677T Mutation 显示文摘 | Wilcken DEL Wang XL Sim AS | 1996 | Arterioscler Thromb Vasc Biol1996，16，： | 1 |
| 4 | The role of direct high-resolution mass spectrometry in foodomics显示文摘 | IBá?EZ C SIMó C GARCíA-CA?AS V | 2015 | Analytical and Bioanalytical Chemistry2015，407，21： | 1 |
| 5 | Distribution in healthy and coronary populations of the MTHFR c677T mutation显示文摘 | Wileken DEL Wang XL Sim AS | 1996 | Arterio Thromb Vasc Bio1996，16，： | 1 |
| 6 | Plasma extracellular superoxide dismutase levels in an Australian population with coronary artery disease显示文摘 | WANG XL ADACHI T SIM AS | 1998 | Arterioscler Thromb Vasc Biol1998，18，12： | 1 |
| 7 | Region-specific regulation of inilammation and pathogenesis in experimental autoimmune encephalomyelitis显示文摘 | Archambault AS Sim J Mccandless EE | 2006 | J Neuroimmunol2006，181，12： | 1 |
| 8 | Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels显示文摘 | Wang XL Mahaney MC Sim AS | 1997 | Arterioscler Thromb Vasc Biol1997，17，11： | 1 |
| 9 | Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes显示文摘 | Wang XL Greeo M Sim AS | 2002 | Atheroselerosis2002，162，： | 1 |
| 10 | Genetic contribution of the endothelial nitric oxide synthase gene to plsmma nitric oxide levels显示文摘 | Wang XL Mahaney MC Sim AS | 1997 | Arteriescler Thromb Vase1997，17，11： | 1 |
| 11 | A smoking-dependent risk of coronary artery disease associated with a polymorphism of endothelial nitric oxide synthase gene显示文摘 | Wang XL Sim AS Badenhop RF | 1996 | Nat Med1996，2，1： | 1 |
| 12 | Genotype dependent and cigarette specific on endothelial nitric oxide synthase gene expression and enzyme activity显示文摘 | Wang XL Sim AS Wang MX | 2000 | FEBS Lett2000，471，1： | 1 |
| 13 | Genetic contribution of the endothelial nitric oxide synthase gene to plsmma nitric oxide levels显示文摘 | Wang XL Mahaney MC Sim AS | 1997 | Arterieseler Thromb Vase Biol1997，17，11： | 1 |
| 14 | A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene显示文摘 | Wang XL Sim AS Badenhop RP | 1996 | Nat Med1996，2，1： | 1 |
| 15 | A smoking-dependent risk of coronary artery disease associated with a polymorphism of endothelial nitric oxide synthase gene显示文摘 | Wang XL Sim AS Badenhop RF | 1996 | J Nat Med1996，2，1： | 1 |
| 16 | A smoking dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene 显示文摘 | Wang XL Sim AS Badenhop RF | 1996 | Nat Med1996，2，1： | 1 |
| 17 | Present and future challenges in food analysis:Foodomics显示文摘 | García-Ca?as V Simó C Herrero M | | 0，，23： | 1 |
| 18 | Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels显示文摘 | Wang XL Mahaney MC Sim AS | 1997 | Arterioscler Thromh Vasc Biol1997，17，11： | 1 |
| 19 | Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels显示文摘 | Wang XL Mahaney MC Sim AS | 1997 | Arterioscler Tbromb Vasc Biol1997，17，11： | 1 |
| 20 | Comparison of the aesthetic facial proportions of southern Chinese and white women 显示文摘 | Sim RS Smith JD Chan AS | 2000 | Arch Facial Plast Surg2000，2，2： | 1 |
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