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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Nuclear transplantation in the bovine embryo:assessment of donor nuclei recipient oocyte显示文摘 | Prather RS Barnes FL Sims ML | 1987 | Biol Reprod1987，37，： | 1 |
| 3 | Development of mouse hepatitis virus and SABS-Cov infectious cDNA construct显示文摘 | Barie RS Sims AC | 2005 | CTMI2005，287，： | 1 |
| 4 | Magnetic resonance im- aging characteristics of renal tumors after radiofrequency ablation 显示文摘 | Svatek RS Sims R Anderson JK | 2006 | Urology2006，67，3： | 1 |
| 5 | Magnetic reso- nance imaging characteristics of renal tumors after radiofrequency ablation显示文摘 | SAVATEK RS SIMS R ANDERSON JK | 2006 | Urology2006，67，3： | 1 |
| 6 | Intimal Hyperplasia and Wall Shear in Arterial Bypass Graft Distal Anastomoses:An In Vivo Model Study显示文摘 | Keynton RS Evancho MM Sims RL | 2001 | J Biomech Eng2001，123，： | 1 |
| 7 | Magnetic resonance imaging characteristics of renal tumors after radiofrequency ablation显示文摘 | Svatek RS Sims R Anderson JK | 2006 | Urology2006，67，3： | 1 |
| 8 | Comparison of the aesthetic facial proportions of southern Chinese and white women 显示文摘 | Sim RS Smith JD Chan AS | 2000 | Arch Facial Plast Surg2000，2，2： | 1 |
| 9 | Development of mouse hepatitis virus and SARS-Cov infectious cDNA construct显示文摘 | Baric RS Sims AC | 2005 | Curr Top Microbiol Immunol2005，287，： | 1 |
| 10 | Quantification of HCV RNA levels and detection of core antigen in do- nations before seroconversion显示文摘 | Grant PR Sims CM Tedder RS | 2002 | Transfusion2002，42，8： | 1 |
| 11 | Nuclear transplantation in early pig embryos显示文摘 | Prather RS Sims MM First NL | 1989 | Biol Reprod1989，41，3： | 1 |
| 12 | Nuclear transplantation in the bovine embryos:Assessment of donor nuclei and recipient oocyte显示文摘 | Barnes FL Sims MM | 1987 | Biol Reprod1987，37，： | 1 |
| 13 | Nuclear transplantation in early pig embryos显示文摘 | Sims MM First NL | 1989 | Biol Reprod1989，41，： | 1 |
| 14 | Development of mouse hepatitis virus and SARS- Cov infectious cDNA construct显示文摘 | Baric RS Sims AC | 2005 | CTMI2005，287，： | 1 |
| 15 | Absence of escherichie coli,listeria monocytogenes,and klebsiella pneumoniae antigens within inflammatory bowel disease tissues 显示文摘 | Walmsley RS Anthony A Sim R | 1998 | J Clin Pathol1998，51，9： | 1 |
| 16 | Nuclear transplantation in early pig embryos显示文摘 | Prather RS Sims MM First NL | 1989 | Biol Reprod1989，41，： | 1 |
| 17 | Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of eiliated cells in viral spread in the conducting airways of the lungs 显示文摘 | Sims AC Barie RS Yount B | 2005 | J Virol2005，79，15： | 1 |
| 18 | Nuclear transplantation in early pig embryos 显示文摘 | Prather RS Sims MM First NL | 1989 | Biology of Reproduction1989，41，1： | 1 |
| 19 | Comparison of the aesthetic facial proportions of southern Chinese and white women 显示文摘 | Sim RS Smith JD Chan AS | 2000 | Arch Facial Plast Surg2000，2，2： | 1 |
| 20 | Magnetic resonance imaging characteristics of renal tumors after radiofrequency ablation 显示文摘 | Savatek RS Sims R Anderson JK | 2006 | Urology2006，67，3： | 1 |
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