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| 1 | Nitrogen in Relation to Photosynthetic Capacity and Accumulation of Osmoprotectant and Nutrients in Brassica Genotypes Grown Under Salt Stress显示文摘Different strategies of the application of nutrients are required to overcome the adverse effects of mustard (Brassica juncea L.) in response to NaCl stress. The objective of the present study was to determine if different added levels of nitrogen (N) in growth medium could alleviate the adverse effects of salt stress on photosynthetic capacity and accumulation of osmoprotectants and nutrients. 14 days mustard seedlings of salt-sensitive (cv. Chuutki) and salt-tolerant (cv. Radha) genotypes were fed with: (i) 0 mmol L-1 NaCl + 0 mg N kg-1 sand (control), (ii) 90 mmol L-1 NaCl + 30 mg N kg-1 sand, (iii) 90 mmol L-1 NaCl + 60 mg N kg-1 sand, (iv) 90 mmol L-1 NaCl + 90 mg N kg-1 sand and (v) 90 mmol L-1 NaCl + 120 mg N kg-1 sand. Under the condition of salinity stress, N application caused a significant ameliorative effect on both genotypes with respect to growth attributes [fresh weight (FW) and dry weight (DW)] and physio-biochemical parameters [percent water content (WC), net photosynthetic rate (PN), stomatal conductance (gs), total chlorophyll (Chl), carbonic anhydrase (CA) activity and malondialdehyde (MDA), nitrogen (N), potassium (K) and sodium (Na) contents, and K/Na ratio] and yield attributes (number of pods/plant, seeds/pod and seed yield/plant). The salt-tolerant genotype exhibited maximum value for growth, physio-biochemical and yield attributes at 60 mg N kg-1 sand than that of salt-sensitive genotype. These results suggest that application of N may ameliorate most of the attributes and prove to be a physiological remedy to increase the tolerance against the ill effects of salt stress in Brassicas. | Manzer H Siddiqui Firoz Mohammad M Nasir Khan Mohamed H Al-Whaibi Ali H A Bahkali | 2010 | Agricultural Sciences in China2010，9，5： | 14 |
| 2 | Enteral stents for the management of malignant colorectal obstruction显示文摘Colorectal cancer(CRC) is the 3rd most common cancer in the United States with more than 10000 new cases diagnosed annually. Approximately 20% of patients with CRC will have distant metastasis at time of diagnosis, making them poor candidates for primary surgical resection. Similarly, 8%-25% of patients with CRC will present with bowel obstruction and will require palliative therapy. Emergent surgical decompression has a high mortality and morbidity, and often leads to a colostomy which impairs the patient's quality of life. In the last decade, there has been an increasing use of colonic stents for palliative therapy to relieve malignant colonic obstruction. Colonic stents have been shown to be effective and safe to treat obstruction from CRC, and are now the therapy of choice in this scenario. In the setting of an acute bowel obstruction in patients with potentially resectable colon cancer, stents may beused to delay surgery and thus allow for decompression, adequate bowel preparation, and optimization of the patient's condition for curative surgical intervention. An overall complication rate(major and minor) of up to 25% has been associated with the procedure. Long term failure of stents may result from stent migration and tumor ingrowth. In the majority of cases, repeat stenting or surgical intervention can successfully overcome these adverse effects. | Jeremy Kaplan Anna Strongin Douglas G Adler Ali A Siddiqui | 2014 | World Journal of Gastroenterology2014，20，37： | 13 |
| 3 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 4 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 5 | Tea beverage in chemoprevention and chemotherapy of prostate cancer显示文摘前列腺癌症(PCa ) 是最经常诊断的恶意和在有在存在的许多 westerncountries.The 的类似的趋势的美国男性的癌症相关的死亡的第二个领先的原因治疗途径和外科的干预一直不能有效地应付这畏惧的疾病。为这些原因,为它的预防和治疗为疾病过程的更好的理解并且为新奇途径的发展加强我们的努力是必要的。从在 vivo 并且在 vitrodata 和流行病学的研究基于可观的证据,在饮料茶获得了为减少几癌症的风险的可观的注意的最近的年里。许多茶的癌症预防措施效果,特别绿的茶看起来被在那里在场的多酚调停。地理证据建议 PCa 的发生和出现在消费茶 regularly.Thisevidence 的人口是更低的建议茶多酚能被外推对 PCa.PCa 优化他们的 chemopreventiveproperties 因为它典型地超过 50 岁并且因此在人被诊断,为 chemoprevention 代表优秀候选人疾病,甚至在通过药理学或营养的干预完成的肿瘤的开发的谦虚延期能在临床上可检测的疾病的发生导致实质的减小。在这评论,我们处理茶的可能的使用的问题,特别绿的茶,为象治疗 ofPCa 一样的预防。 | Imtiaz A SIDDIQUI Mohammad SALEEM Vaqar M ADHAMI Mohammad ASIM Hasan MUKHTAR | 2007 | Acta Pharmacologica Sinica2007，28，9： | 4 |
| 6 | 顽固性高血压与由心内容积决定的血管内液体潴留无关显示文摘顽固性高血压(refractory hypertension,RfHTN)是一种极端的抗高血压治疗失败的表现形式,定义为使用了包括长效噻嗪类和盐皮质激素受体拮抗剂在内的≥5种药时血压仍控制欠佳。RfHTN是难治性高血压(resistant hypertension,RHTN)的一个亚组,RHTN定义为使用≥3种降压药(包括利尿剂)后血压仍〉135/85mm Hg(1mm Hg=0.133kPa)。 | 刘青 叶鹏 Velasco A Siddiqui M Kreps E Kolakalapudi P Dudenbostel T Arora G Judd EK Prabhu SD Lloyd SG Oparil S Calhoun DA | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 7 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 8 | Endoscopic ultrasound-fine needle injection for oncological therapy显示文摘The minimal invasiveness and precision of endoscopicultrasound(EUS) has lead to both its widespread use as a diagnostic and staging modality for gastrointestinal and pancreaticobiliary malignancies, and to its expand-ing role as a therapeutic modality. EUS-guided celiac plexus neurolysis is now a well-accepted modality for palliation of pain in patients with pancreatic cancer. EUS-guided ablation, brachytherapy, fiducial marker placement, and antitumor agent injection have been described as methods of performing minimally invasive oncological therapy. EUS-fine needle injection may be performed as adjunctive, alternative, or palliative treatment. This review summarizes the studies to date that have described these methods. A literature search using the Pub Med/MEDLINE databases was performed. While most published studies to date are limited with disappointing outcomes, the concept of a role of EUS in oncological therapy seems promising. | Jeremy Kaplan Amaara Khalid Natalie Cosgrove Ayesha Soomro Syed Mohsin Mazhar Ali A Siddiqui | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 2 |
| 9 | Association of multidrug resistance in epilepsy with a polymorphism in the druytransporter gene ABCBI显示文摘 | Siddiqui A Kerb R Weale M E | 2003 | N Fngl J Med2003，348，15： | 1 |
| 10 | Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gane ABCB1 显示文摘 | Siddiqui A Kerb R Weale ME | 2003 | N Engl J Med2003，348，15： | 1 |
| 11 | Schistosomiasis vaccines显示文摘 | Siddiqui A A Siddiqui B A Ganley-Leal L | 2011 | Hum vaccines2011，7，11： | 1 |
| 12 | Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of Pregnancy 显示文摘 | Laifer S A Stiller R J Siddiqui D S | 2001 | J Matem Fetal Med2001，10，2： | 1 |
| 13 | NUT midline carcinomamimicking tonsillitis in an eight-year-old girl 显示文摘 | Rutt A L Poulik J Siddiqui A H ef al | 2011 | Ann Otol RhinolLaryngol2011，120，8： | 1 |
| 14 | Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf - 1 via oxidative stress 显示文摘 | Chen J Siddiqui A | 2007 | J Virol2007，81，12： | 1 |
| 15 | Hepatitis B virus transactivator protein X interacts with the TATA-binding protein 显示文摘 | QADRI I MAGUIRE H F SIDDIQUI A | 1996 | Proc Natl Acad Sci U S A1996，93，10： | 1 |
| 16 | An evaluation of cefaclor in Pakistani children with pharyngotonsillitis显示文摘 | SIDDIQUI SJ AWAN A EKANGAKIC A | 2002 | J Pak Med Assoc2002，52，10： | 1 |
| 17 | Dispersion and func- tionalization of carbon nanotubes or polymer-based nanocom- posites: A review 显示文摘 | Ma P C Siddiqui N A Marom G | 2010 | Composites Part A: Applied Science and Manufacturing2010，41，10： | 1 |
| 18 | Primary gastric lymphoma 显示文摘 | Al-Akwaa A M Siddiqui N Al-Mofleh I A | 2004 | World J Gastroenterol2004，10，1： | 1 |
| 19 | Role of cyanide production by Pseudomonas fluorescens CHA0 in the suppression of root-knot nematodes, Meloidogyne javanica in tomato显示文摘 | Siddiqui I A Shaukat S S Sheikh I H | 2006 | World Journal of Microbiology & Biotechnology2006，26，： | 1 |
| 20 | Dispersion and Functionalization of Carbon Nanotubes for Polymer-based Nanocomposites: A Review显示文摘 | Ma P C Siddiqui N A Marom G | 2010 | Composites Part A: Applied Science and Manufacturing2010，41，10： | 1 |
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