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| 1 | MTERF1 regulates the oxidative phosphorylation activity and cell proliferation in HeLa cells显示文摘mitochondrial 抄写结束因素(MTERF ) 家庭是一组高度保存的 DNA 有约束力的蛋白质 composedof 四个关键成员, MTERF14。迄今为止,几研究在 mitochondrial genomeand 上调查了 MTERF1 的有约束力的地点 mitochondrial 基因抄写的规定,而是在 mitochondrial 基因 transcriptionregulation 之间的更复杂的连接, mitochondrial 氧化 phosphorylation (OXPHOS ) ,和房间增长仍然糟糕被理解。在这研究,我们构造了在表示上和是进 HeLa 房间的 transfected 调查 MTERF1 的功能的 MTERF1 的击倒的向量。结果证明尽管 MTERF1 是 mitochondrial 基因抄写的一个 positiveregulatory 因素,它没在 MTERF1 的 mitochondrial DNA.Over表示的复制上有重要效果增加的 mitochondrial 氧化 phosphorylation 活动和支持的 ATP 合成, cyclin D1expression ,和房间增长它的击倒的禁止的 ATP 合成,减少的 cyclin D1 表示,并且 slowedthe 房间生长。这些结果建议 MTERF1 可以由在 HeLa 房间调整氧化 phosphorylationactivity 支持房间增长。最终,这些调查结果由提供新奇卓见进位于房间增长下面的潜在的机制在 MTERF 家庭的 physiologicalfunctions 上为进一步、更最后的研究创造一个基础规定。 | Guiyuan Chen Jie Dai Shirui Tan Shengke Meng Zhongjian Liu Meizhang Li Qinghua Cui Min Yu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 10 |
| 2 | The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism显示文摘Streptococcus mutans(S.mutans)is generally regarded as a major contributor to dental caries because of its ability to synthesize extracellular polysaccharides(EPS)that aid in the formation of plaque biofilm.The VicRKX system of S.mutans plays an important role in biofilm formation.The aim of this study was to investigate the effects of vicK gene on specific characteristics of EPS in S.mutans biofilm.We constructed single-species biofilms formed by different mutants of vicK gene.Production and distribution of EPS were detected through atomic force microscopy,scanning electron microscopy and confocal laser scanning microscopy.Microcosmic structures of EPS were analyzed by gel permeation chromatography and gas chromatography-mass spectrometry.Cariogenicity of the vicK mutant was assessed in a specific pathogen-free rat model.Transcriptional levels of cariogenicityassociated genes were confirmed by quantitative real-time polymerase chain reaction.The results showed that deletion of vicK gene suppressed biofilm formation as well as EPS production,and EPS were synthesized mostly around the cells.Molecular weight and monosaccharide components underwent evident alterations.Biofilms formed in vivo were sparse and contributed a decreased degree of caries.Moreover,expressional levels of genes related to EPS synthesis were down-regulated,except for gtfB.Our report demonstrates that vicK gene enhances biofilm formation and subsequent caries development.And this may due to its regulations on EPS metabolism,like synthesis or microcosmic features of EPS.This study suggests that vicK gene and EPS can be considered as promising targets to modulate dental caries. | Yalan Deng Yingming Yang Bin Zhang Hong Chen Yangyu Lu Shirui Ren Lei Lei Tao Hu | 2021 | International Journal of Oral Science2021，13，4： | 2 |
| 3 | A review on COVID-19 transmission,epidemiological features,prevention and vaccination显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused hundreds of millions of infections and millions of deaths over past two years.Currently,many countries have still not been able to take the pandemic under control.In this review,we systematically summarized what we have done to mitigate the COVID-19 pandemic,from the perspectives of virus transmission,public health control measures,to the development and vaccination of COVID-19 vaccines.As a virus most likely coming from bats,the SARS-CoV-2 may transmit among people via airborne,faecal-oral,vertical or foodborne routes.Ourmeta-analysis suggested that the R0 of COVID-19 was 2.9(95%CI:2.7–3.1),and the estimates in Africa and Europe could be higher.The median Rt could decrease by 23–96%following the nonpharmacological interventions,including lockdown,isolation,social distance,and face mask,etc.Comprehensive intervention and lockdown were the most effective measures to control the pandemic.According to the pooled R0 in our meta-analysis,there should be at least 93.3%(95%CI:89.9–96.2%)people being vaccinated around the world.Limited amount of vaccines and the inequity issues in vaccine allocation call for more international cooperation to achieve the antiepidemic goals and vaccination fairness. | Yuqin Zhang Gonghua Wu Shirui Chen Xu Ju Wumitijiang Yimaer Wangjian Zhang Shao Lin Yuantao Hao Jing Gu Jinghua Li | 2022 | Medical Review2022，2，1： | 2 |
| 4 | Intranasal administration of melatonin starch microspheres 显示文摘 | Shirui Mao Jianming Chen Zhenping Wei | 2004 | International Journal of Pharmaceutics2004，272，： | 1 |
| 5 | Intranasal administration of melatonin starch microspheres 显示文摘 | SHIRUI MAO JIANMING CHEN ZHENPING WEI | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 6 | Prediction of simulating and experiments for Co-based alloy laser clad- ding by HPDL 显示文摘 | Shirui Guo Zhijun Chen Dingbao Cai | 2013 | Physics Procedia2013，50，： | 1 |
| 7 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei Huan Liu Dianzhou Bi | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 8 | Intranasal administration of melatonin starch micro-spheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 9 | Fabrication of large-area uniform carbon nanotube foams as near-critical-density targets for laser–plasma experiments显示文摘Carbon nanotube foams(CNFs)have been successfully used as near-critical-density targets in the laser-driven acceleration of high-energy ions and electrons.Here we report the recent advances in the fabrication technique of such targets.With the further developed floating catalyst chemical vapor deposition(FCCVD)method,large-area(>25 cm^(2))and highly uniform CNFs are successfully deposited on nanometer-thin metal or plastic foils as double-layer targets.The density and thickness of the CNF can be controlled in the range of 1−13 mg/cm^(3)and 10−200µm,respectively,by varying the synthesis parameters.The dependence of the target properties on the synthesis parameters and the details of the target characterization methods are presented for the first time. | Pengjie Wang Guijun Qi Zhuo Pan Defeng Kong Yinren Shou Jianbo Liu Zhengxuan Cao Zhusong Mei Shirui Xu Zhipeng Liu Shiyou Chen Ying Gao Jiarui Zhao Wenjun Ma | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 10 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianrning Chen Zhenping Wei Huan Liu Dianzhou Bi | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 11 | Intranasal administration of melatonin starch microspheres 显示文摘 | Mao Shirui Chen Jianming Wei Zhenping | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 12 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 13 | Intranasal administration of melatonin starch microspheres显示文摘 | Mao Shirui Chen Jianming Wei Zhenping | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 14 | A Neural Circuit Mechanism Controlling Breathing by Leptin in the Nucleus Tractus Solitarii显示文摘Leptin,an adipocyte-derived peptide hormone,has been shown to facilitate breathing.However,the central sites and circuit mechanisms underlying the respiratory effects of leptin remain incompletely understood.The present study aimed to address whether neurons expressing leptin receptor b(LepRb)in the nucleus tractus solitarii(NTS)contribute to respiratory control.Both chemogenetic and optogenetic stimulation of LepRb-ex-pressing NTS(NTS^(LepRb))neurons notably activated breathing.Moreover,stimulation of NTS^(LepRb) neurons projecting to the lateral parabrachial nucleus(LPBN)not only remarkably increased basal ventilation to a level similar to that of the stimulation of all NTS^(LepRb) neurons,but also activated LPBN neurons projecting to the preBotzinger complex(preBotC).By contrast,ablation of NTS^pRb neurons projecting to the LPBN notably eliminated the enhanced respiratory effect induced by NTSLepRb neuron stimulation.In brainstem slices,bath application of leptin rapidly depolarized the membrane potential,increased the spontaneous firing rate,and accelerated the Ca2+transients in most NTSLepRb neurons.Therefore,leptin potentiates breathing in the NTS most likely via an NTS-LPBN-preBdtC circuit. | Hongxiao Yu Luo Shi Jinting Chen Shirui Jun Yinchao Hao Shuang Wang Congrui Fu Xiang Zhang Haiyan Lu Sheng Wang Fang Yuan | 2022 | Neuroscience Bulletin2022，38，2： | 1 |
| 15 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei Huan Liu Dianzhou Bi | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 16 | Intranasal administration of melatonin starch microsphercs 显示文摘 | Shirui Mao Jianming Chen Zhenping Wei | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 17 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei Huan Liu Dianzhou Bi | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
| 18 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei | 2004 | Intemational Journal of Pharmaceutics2004，272，12： | 1 |
| 19 | Damping forced oscillations in power system via interline power flow controller with additional repetitive control显示文摘With the continuous expansion of power systems and the application of power electronic equipment, forced oscillation has become one of the key problems in terms of system safety and stability. In this paper, an interline power flow controller (IPFC) is used as a power suppression carrier and its mechanism is analyzed using the linearized state-space method to improve the system damping ratio. It is shown that although the IPFC can suppress forced oscillation with well-designed parameters, its capability of improving the system damping ratio is limited. Thus, combined with the repetitive control method, an additional repetitive controller (ARC) is proposed to further dampen the forced power oscillation. The ARC control scheme is characterized by outstanding tracking performance to a system steady reference value, and the main IPFC controller with the ARC can provide higher damping, and further reduce the amplitude of oscillations to zero compared with a supplementary damping controller (SDC). Simulation results show that the IPFC with an ARC can not only greatly reduce the oscillation amplitude, but also actively output the compensation power according to the reference value of the ARC tracking system. | Shirui Feng Xi Wu Zhenquan Wang Tao Niu Qiong Chen | 2021 | Protection and Control of Modern Power Systems2021，6，1： | 1 |
| 20 | Intranasal administration of melatonin starch microspheres显示文摘 | Shirui Mao Jianming Chen Zhenping Wei | 2004 | International Journal of Pharmaceutics2004，272，12： | 1 |
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