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| 1 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 2 | Outcomes of primary percutaneous coronary intervention for acute ST-elevation myocardial infarction in patients aged over 75 years显示文摘背景在有圣举起心肌的梗塞(STEMI ) 的老病人的最佳的灌注策略仍然保持不清楚。这研究的目的是评估安全,在里面医院和一个年临床的为病人的结果有收到主要经皮的冠的干预(一种总线标准)的 STEMI 的 75 岁,由保守 approach.Methods 与那些相比对待有 STEMI 的 75 岁介绍了的 102 个病人 12 个小时随机仅仅被分配到主要一种总线标准( n=50 )或保守治疗( n=52 )。在一个年的基线特征,在里面医院结果和主要不利心脏的事件(向),包括的死亡,非致命的心肌的梗塞和目标容器 revascularization 临床的后续在二 groups.Results 年龄之间被比较,性分发,为冠的动脉疾病的风险因素,梗塞地点和临床的功能的地位在二个组之间是类似的,但是在主要一种总线标准组的病人在住院期间收到了更少的 low-molecularweight 肝磷脂。与保守的组相比,在主要一种总线标准的病人组织重新梗塞和死亡和弄短的医院停留的有的显著地更低的出现率。为在 30 天的后续的在里面医院幸存的合成端点在二个组之间是类似的,但是一个年向率在主要一种总线标准组是显著地更低的(21.3% 和 45.2% , P=0.029 ) 。左室的喷射部分显著地没在后续期间在两个组被改变。Multivariate 分析揭示了那个主要一种总线标准(OR=0.34, 95% CI:0.21-0.69, P =0.03 ) 为我们的结果显示了的 75 years.Conclusion 的 STEMI 病人的改进没有向的幸存率那个主要一种总线标准在与 STEMI 为老病人减少在里面医院死亡和一个年向率安全、有效。 | ZHANG Qi ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zhen-kun ZHENG Ai-fang ZHANG Xian SHEN Wei-feng | 2006 | Chinese Medical Journal2006，，14： | 54 |
| 3 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 4 | Elevation of tumor necrosis factor-α,interleukin-1β and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes显示文摘有调停毒素的胰腺的损坏的背景大动物模型关于糖尿病 mellitus 和心血管的糖尿病的复杂并发症在研究广泛地被使用了。试图证实有 streptozotocin ( STZ )的中国贵州 minipig 模型导致了糖尿病并且描绘动物的现在的学习由在大动脉的墙中分析煽动性的 cytokine 层次当模特儿,例如肿瘤坏死因素( TNF ), interleukin-1 ( IL-1 )和 interleukin-6 ( IL-6 ) .Methods 22 男中国贵州 minipigs (变老, 4~6 个月;重量, 20 kg 到 30 kg ) 被划分成导致 STZ 的糖尿病的组(n=12 ) 和控制组(n=10 ) 。STZ (125 mg/kg ) 被管理导致多糖症,以后,胰岛素被用来在 10 mmol/L 下面控制 fasting 血葡萄糖层次。口头的葡萄糖忍耐测试(OGTT ) 以前被执行并且在 STZ 管理和丙氨酸 transaminase,天门冬素 transaminase,白朊,血脲氮, creatinine,类脂化合物和白色的浆液集中以后的一个月血房间计数以前并且六个月以后被测量。在六个月和胰为小岛房间 immunohistochemically 被检验以后,在两个组的动物是 euthanized。糖尿病的 minipigs 和控制的大动脉的 intima 在由西方的污点中等的调节的组织为 TNF- 水平被分析。在大动脉的 intima 的 TNF- , IL-1 和 IL-6 mRNA 层次是由反向的抄写和聚合酶链反应(RT-PCR ).Results 的 assayed 在浆液葡萄糖层次的重要举起被观察在 STZ 正式就职(P0.001 ) 和显著地增加的 OGTT 价值以后的一个月和六个月被注意,与基线数据相比。正常的胰有许多不规则的大小的小岛和小岛房间的小簇,当在糖尿病的 minipigs 的胰小岛房间几乎消失了时。没有统计差别以前在生物化学的考试的浆液集中被通知并且在 STZ 以后的六个月感应。西方的污点证明在 aotic intima 的戏剧性地增加的TNF-水平调节了TNF-, IL-1 和 IL-6 的中等、重要的举起 mRNA 层次被现在的学习建立了的 RT-PCR.Conclusions 揭示有 导致STZ 的 diabetes.Inflammatory cytokines 的中国贵州 minipig 模型(TNF-, IL-1 和 IL-6 )显著地在糖尿病的 minipigs 的大动脉的 intima 提高了。 | LU Lin ZHANG Qi PU Li-jin XU Xue-wei ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zheng-kun LU An-kang DING Feng-hua SHEN Jie CHEN Qiu-jin LOU Sheng FANG Dan-hong SHEN Wei-feng | 2007 | Chinese Medical Journal2007，，6： | 43 |
| 5 | Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.)显示文摘Gibberellin (GA) 2-oxidase plays a key role in the GA catabolic pathway through 2β-hydroxylation.In the present study,we isolated a CaMV 35S-enhancer activation tagged mutant,H032.This mutant exhibited a dominant dwarf and GA-deficient phenotype,with a final stature that was less than half of its wild-type counterpart.The endogenous bioactive GAs are markedly decreased in the H032 mutant,and application of bioactive GAs (GA3 or GA4) can reverse the dwarf phenotype.The integrated T-DNA was detected 12.8 kb upstream of the OsGA2ox6 in the H032 genome by TAIL-PCR.An increased level of OsGA2ox6 mRNA was detected at a high level in the H032 mutant,which might be due to the enhancer role of the CaMV 35S promoter.RNAi and ectopic expression analysis of OsGA2ox6 indicated that the dwarf trait and the decreased levels of bioactive GAs in the H032 mutant were a result of the up-regulation of the OsGA2ox6 gene.BLASTP analysis revealed that OsGA2ox6 belongs to the class III of GA 2-oxidases,which is a novel type of GA2ox that uses C20-GAs (GA12 and/or GA53) as the substrates.Interestingly,we found that a GA biosynthesis inhibitor,paclobutrazol,positively regulated the OsGA2ox6 gene.Unlike the over-expression of OsGA2ox1,which led to a high rate of seed abortion,the H032 mutant retained normal flowering and seed production.These results indicate that OsGA2ox6 mainly affects plant stature,and the dominant dwarf trait of the H032 mutant can be used as an efficient dwarf resource in rice breeding. | Jian Huang Ding Tang Yi Shen Baoxiang Qin Lilan Hong Aiqing You Ming Li Xin Wang Hengxiu Yu Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，1： | 36 |
| 6 | Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients显示文摘AIM:To investigate the efficacy and safety of imatinib dose escalation in Chinese patients with advanced gastrointestinal stromal tumor (GIST).METHODS:Advanced GIST patients previously failing 400 mg imatinib treatment were enrolled in this study.Patients received imatinib with dose escalation to 600 mg/d,and further dose escalation to 800 mg/d if imatinib 600 mg/d failed.Progression-free survival,overall survival,clinical efficacy,c-kit/PDGFRA genotype and safety were evaluated.RESULTS:52 patients were enrolled in this study.For the 47 evaluable patients receiving imatinib (600 mg/d),the disease control rate was 40.4%,and the median progression-free survival for all patients was 17 wk (95% CI:3.9-30.1).The median overall survival after dose escalation was 81 wk (95% CI:36.2-125.8).Adverse events,mainly edema,fatigue,granulocytopenia and skin rash were tolerable.However,further dose escalation (800 mg/d) in 14 cases was ineffective,with disease progression and severe adverse events.Among 30 cases examined for gene mutations,patients with exon 9 mutations experienced a better progression-free survival of 47 wk.CONCLUSION:Imatinib dose escalation to 600 mg/d is more appropriate for Chinese patients and may achieve further survival benefit. | Jian Li Ji-Fang Gong Jie Li Jing Gao Nai-Ping Sun Lin Shen | 2012 | World Journal of Gastroenterology2012，18，7： | 35 |
| 7 | Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia显示文摘 | Jian SHEN Yu ZHU Hai YU Zuo-xu FAN Feng XIAO Pan WU Qi-hui ZHANG Xiao-xing XIONG Jian-wei PAN Ren-ya ZHAN | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，3： | 36 |
| 8 | Morphological and functional changes of mitochondria in apoptotic esophageal carcinoma cells induced by arsenic trioxide显示文摘AIM:To demonstrate that mitochondrial morphological andfunctional changes are an important intermediate link in thecourse of apoptosis in esophageal carcinoma calls inducedby As_2O_3.METHODS:The esophageal carcinoma call line SHEEC1,established in our laboratory,was cultured in 199 growthmedium,supplemented with 100mL·L^(-1)calf serum and3 mol·L^(-1)As_2O_3(the same below).After 2,4,6,12,24 hof drug adding,the SHEECl calls were collected for light-and electron-microscopic examination.The mitochondriawere labeled by Rhodamine fluorescence probe and thefluorescence intensity of the mitochondria was measured byflow cytorneter and cytofluorimetric analysis.Further,themitochondrial transmembrane potential(MTP,ΔΨm)change was also calculated.RESULTS:The mitochondrial morphological change afteradding As_2O_3 could be divided into three stages.In theearly-stage(2-6h)after adding As203,an adaptiveproliferation of mitochondria appeared;in the mid-stage(6-12 h)a degenerative change was observed;and in the late-stage(12-24 h)the mitochondria swelled with outermembrane broken down and then calls death with apoptoticchanges of nucleus.The functional change of themitochondria indicated by fluorescent intensity,whichreflected the MTP status of mitochondria,was in accordancewith morphological change of the mitochondria.Thefluorescent intensity increased at early-stage,decUned inmid-stage and decreased to the lowest in the late-stage.24h after As_2O_3 adding,the cell nucleus showed typicalapoptotic changes.CONCLUSION:Under the inducement of As_2O_3,the earlyapoptotic changes of SHEEC1 cells ware the apparentmorphological and functional changes of mitochondria,afterwards the nucleus changes followed.It is consideredthat changes of mitochondria are an important intermediatelink in the course of apoptosis of esophageal carcinoma cells induced by As_2O_3. | Zhong-Ying Shen Jian Shen Qiao-Shan Li Department of Pathology,Medical College of Shantou University,Shantou 515031,Guandong Province,China Cai-Yun Chen Central Lab.Medical College of Shantou University Jiong-Yu Chen Central Lab.of Tumor Hospital,Medical College of Shantou University Yi Zeng Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2002 | World Journal of Gastroenterology2002，8，1： | 35 |
| 9 | Prospective multicenter randomized trial comparing physician versus patient transfer for primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction显示文摘背景:主要经皮的冠的干预(一种总线标准) 与尖锐圣片断举起为病人作为第一种治疗学的选择被识别了心肌的梗塞(STEMI ) 。把病人转移到一个一种总线标准中心的策略最近与尖锐 STEMI 为那些被推荐对一种总线标准不能的医院在场,它包括设备或富有经验的操作员的缺乏。在中国,一些本地医院与一种总线标准设备被装备了,但是他们没有医生们为执行主要一种总线标准限制了的 interventional。这研究被进行估计把医生转移到与尖锐 STEMI 为病人执行主要一种总线标准的一所装备一种总线标准的医院的策略的可行性,安全和功效。方法:有症状演讲 = 的 334 个连续 STEMI 病人到 2007 年 11 月的从 2005 年 11 月的五所本地医院里的 12 个小时被使随机化由任何一个医生转移收到主要一种总线标准(医生转移组, n=165 ) 或耐心的转移(耐心的转移组, n=169 ) 策略。Door-to-balloon 时间,在里面医院和 30 天的主要不利心脏的事件(向,包括的死亡,非致命的重新梗塞,和目标容器 revascularization ) 在二个组之间被比较。结果:在二个组之间的基线特征是可比较的。在心肌的梗塞(TIMI ) 的血栓溶解 3 流动在起始的血管造影术在医生转移组在更多的病人被揭示(17.6% 对 10.1% , P<0.05 ) 。主要一种总线标准的成功率(96.3% 对 95.4% , P>0.05 ) 并且一些医院停留在二个组之间是类似的((15+/-4 ) 天对(14+/-3 ) 天, P>0.05 ) 。在医生转移组, door-to-balloon 时间显著地被弄短((95+/-20 ) 纪录对(147+/-29 ) 纪录, P<0.0001 ) 并且更多的病人与不到 90 纪录的 door-to-balloon 时间收到了主要一种总线标准(21.2% 对 7.7% , P<0.001 ) 。在住院期间,向发生在在医生和耐心的转移的 6.7% 病人和 11.2% 组,分别地(P=0.14 ) 。在 30 天的临床的后续,死亡的出现率,非致命的重新梗塞,和目标容器 revascularization (TVR ) 是 3.6% 对 5.9% , 4.2% 对 8.9% ,和 1.2% 对 2.4% 在医生和病人转移组,分别地(所有 P>0.05 ) 。累积合成向显著地被减少(8.9% 对 17.2% , P=0.03 ) 并且向免费幸存(91.0% 对 82.9% , P<0.05 ) 显著地在 30 天在医生转移组被改进。结论:把医生转移到本地医院与尖锐 STEMI 为病人执行主要一种总线标准的策略在减少 door-to-balloon 时间和 30 天的向率可行、安全、有效。 | ZHANG Qi ZHANG Rui-yan QIU Jian-ping ZHANG Jun-feng WANG Xiao-long JIANG Li LIAO Min-lei ZHANG Jian-sheng HU Jian YANG Zheng-kun SHEN Wei-feng | 2008 | Chinese Medical Journal2008，，6： | 33 |
| 10 | Impact of different clinical pathways on outcomes of patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the RAPID-AMI study显示文摘背景当前的指南作为选择的第一治疗支持主要经皮的冠的干预(主要一种总线标准)( 与 thrombolytic 治疗对比) 为有尖锐圣片断举起的病人心肌的梗塞(STEMI ) 特别当在 12 小时症状发作以内交付了时。我们试图从 2005 年 11 月与 STEMI.Methods 在病人在结果在灌注延期和随后的改进的减小上评估不同临床的小径的影响到 2007 年 11 月,有明确的 STEMI 的 546 个连续病人,在在紧急情况房间的到达之上是 triaged 经历主要一种总线标准,被包括。他们, 271 个病人直接被带到 catheterization 实验室(快速的组) ,并且 275 个病人首先进入冠的照顾单位(CCU ) 或心脏的病房,然后转了到 catheterization 实验室(非快速的组) 。主要端点是 door-to-balloon ( D28 )时间,并且第二等的端点包括了山峰 CK-MB 水平和主要心脏的不利事件(向)的率在住院期间并且在30天的临床的 follow-up.Results 基线临床的特征包括死亡,梗塞,或目标容器 revascularization 估计的梗塞尺寸, angiographic 特征和程序的成功率在二个组之间是可比较的,除了更多的病人以前收到了 glycoprotein b/a 受体禁止者之外一D2B 时间被弄短((108 ? ㈨ ? 洠污 ???? 畯 ? 晡整 ? 桴 ? 灯牥瑡潩 ? 慷 ? 楳湧晩捩湡汴 ? 楨桧牥琠慨 ? 桴瑡漠 ? 桴 ? 湫 ' 覞煬潠 P 潲灵吗?? | ZHANG Qi ZHANG Rui-yan QIU Jian-ping JIN Hui-gen ZHANG Jun-feng WANG Xiao-long JIANG Li LIAO Min-lei HU Jian DING Feng-hua ZHANG Jian-sheng SHEN Wei-feng | 2009 | Chinese Medical Journal2009，，6： | 32 |
| 11 | Ureteroscopic lithotripsy using holmium laser for 187 patients with proximal ureteral stones显示文摘 | LIU Ding-yi HE Hong-chao WANG Jian TANG Qi ZHOU Yan-feng WANG Ming-wei CHU Cheng-long ZHANG Chong-yu ZHU Yu ZHOU Wen-long SHEN Zhou-jun | 2012 | Chinese Medical Journal2012，，9： | 34 |
| 12 | Randomized comparison of intracoronary tirofiban versus urokinase as an adjunct to primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: results of the ICTUS-AMI trial显示文摘 | ZHU Tian-qi ZHANG Qi DING Feng-hua QIU Jian-ping JIN Hui-geng JIANG Li LU Lin ZHANG Rui-yan HU Jian YANG Zhen-kun SHEN Ying SHEN Wei-feng | 2013 | Chinese Medical Journal2013，，16： | 27 |
| 13 | A national report from China Liver Transplant Registry: steroid avoidance after liver transplantation for hepatocellular carcinoma显示文摘Objective:We aimed to evaluate the efficacy and safety of steroid-free immunosuppression after liver transplantation(LT)for hepatocellular carcinoma(HCC).Methods:We retrospectively analyzed HCC recipients without steroids after LT(SF group,n=368)based on the China Liver Transplant Registry(CLTR)database.These recipients were matched 1:2 with patients using steroids(S group,n=736)for the same period after LT for HCC,according to propensity scores.Results:Multivariate analysis indicates that recipients with younger age[odds ratio(OR),1.053;P=0.011],preoperative hepatitis B virus(HBV)DNA≥1,000 copies/mL(OR,2.597;P=0.004)and beyond Milan criteria(OR,4.255;P<0.001)were identified as the risk factors associated with tumor recurrence in steroid avoidance recipients after LT.The patients fulfilling the Milan criteria in the SF group presented higher overall and tumor-free survival rates than those in the S group(P<0.05).Multivariate analysis revealed that recipient beyond Milan criteria was an independent prognostic factor for overall survival(OR,1.690;P<0.001)and tumor-free survival(OR,2.066;P<0.001).The incidences of new-onset diabetes mellitus(21.20% vs.33.29%,P<0.001),new-onset hypertension(10.05%vs.18.61%,P<0.001)and hyperlipidemia(4.08% vs.7.20%,P=0.042)were significantly lower in the SF group.Conclusions:Steroid-free immunosuppression could be safe and feasible for HBV-related HCC patients in LT.Age,HBV DNA level and Milan criteria maybe risk factors associated with tumor recurrence in steroid avoidance recipients.Recipient beyond Milan criteria was an independent prognostic factor and recipient fulfilling Milan criteria can benefit the most from steroid-free immunosuppression. | Qiang Wei Feng Gao Runzhou Zhuang Qi Ling Qinghong Ke Jian Wu Tian Shen Mangli Zhang Min Zhang Xiao Xu Shusen Zheng | 2017 | Chinese Journal of Cancer Research2017，29，5： | 25 |
| 14 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 15 | Different dose combinations of bortezomib and dexamethasone in the treatment of relapsed or refractory myeloma: an open-label,observational, multi-center study in China显示文摘背景尽管以前的临床的学习表明与 dexamethasone 相结合的 bortezomib 改进了 relapsed 或倔强的多重骨髓瘤(RRMM ) 的结果, bortezomib 和 dexamethasone 的最佳的剂量联合仍然保持未知。这试用试图与 relapsed 在 168 个病人全部的 China.Methods A 在 RRMM 病人的治疗观察 bortezomib 和 dexamethasone 的不同剂量联合的功效和安全多重骨髓瘤(公里)对倔强在以免二优先的治疗在这 multicenter 被注册,开标签,非使随机化,未来的临床的试用。二十个病人为多达 8 个周期和口头或静脉内的 dexamethasone 收到了为 2 星期一个 3 星期的周期两次每周的 bortezomib 的 1.3 mg/m2 在日子并且在每 bortezomib 剂量(组 1 ) 以后的 20 mg;66 个病人收到了 bortezomib 和 dexamethasone 的不到 1.3 mg/m2 (0.7-1.0 mg/m2 ) 一样的时间表(组 2 ) 上的 20 mg;37 个病人收到了 40 mg (组 3 ) 和 45 个病人收到了的 bortezomib 和 dexamethasone 的 1.3 mg/m2 bortezomib 和 dexamethasone 的不到 1.3 mg/m2 (0.7-1.0 mg/m2 ) 40 mg (组 4 ) 。反应为血和髓移植根据欧洲组的标准被评估并且由一个独立评论委员会证实了。不利事件根据国家癌症研究所被分级普通毒性标准,版本 3.0。结果组的中部的年龄 1 ~ 4 分别地是 61,62, 56,和 60 年。大多数病人在公里的阶段/,最普通的子类型是对组 1~4 的 bortezomib 和 dexamethasone 的全面反应的率是的 IgG 72.2 ( 13/18 ), 73.8 ( 48/65 ), 78.8 ( 26/33 )并且 78.0 ( 32/41 )( P=0.91 ),包括 22.2 的完全的反应率( 4/18 ), 20.0 ( 13/65 ), 33.3 ( 11/33 )并且 29.3 ( 12/41 )( P=0.67 )分别地。在这 4 个组(P 0.05 ) 之中及时没有统计意义到前进和全面幸存。在全部 4 个组的任何等级的最通常不利的事件是疲劳,胃肠的效果,外部神经病和 thrombocytopenia ,并且除了外部神经病在组 3 更经常被报导之外,在在 4 个组( P 0.05 )之中的不利事件的数字没有意义( 36.3 )比在组 2 ( 13.8 , P 0.05 )并且组织 4 ( 14.6 , PO.05 ) .Conclusions bortezomib 和 dexamethasone 的联合在中国 RRMM 病人与高回答被联系。功效的重要差别都没在 bortezomib 和 dexamethasone 的不同剂量联合被检测。而且,没有在中国与 RRMM 在病人的治疗影响结果, bortezomib 的低剂量减少了外部神经病的发生。 | YUAN Zhen-gang JIN Jie HUANG Xiao-jun LI Yan CHEN Wen-ming LIU Zhuo-gang CHEN Xie-qun SHEN Zhi-xiang HOU Jian | 2011 | Chinese Medical Journal2011，，19： | 24 |
| 16 | One-year clinical outcomes of Chinese sirolimus-eluting stent in the treatment of unselected patients with coronary artery disease显示文摘 | ZHANG Qi ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zhen-kun NI Jun FANG Yue-hua ZHANG Xian SHEN Wei-feng | 2006 | Chinese Medical Journal2006，，2： | 23 |
| 17 | Long term clinical outcomes in patients with moderate renal insufficiency undergoing stent based percutaneous coronary intervention显示文摘有结束阶段的背景病人肾的疾病在经皮的冠的干预(一种总线标准) 和在这些病人的 drug-eluting stent 培植的效果仍然保持不清楚以后,在临床的结果上从中等肾的不足的冠的动脉疾病,而是影响有高死亡。在 stent 基于一种总线标准并且检验了 drug-eluting stent 培植是否能有利影响临床的 outcome.Methods 以后,这研究在死亡和主要不利心脏的事件(向)上决定了中等肾的不足的长期的效果死亡的主要不利心脏的事件和原因为从1月1日经历经皮的干预的 1012 个病人被决定, 2002 到在上海 Ruijin 的2004年12月31日医院。基于估计的 creatinine 清理层次,长期的结果与估计的 creatinine 清理 60 ml/min 在病人之间被作比较(肾的不足组;n=410 ) 并且那些与估计的 creatinine 清理 60 ml/min (控制组;n=602 ) 。亚群分析是也在成功的一种总线标准以后在后续(一般水准 17 月)期间在 PCI.Results 期间与在药 eluting stent ( n=264 )和赤裸的金属 stent 培植( n=146 )之间的肾的不足走向病人,死亡的所有原因(7.1%对2.3%, P0.01 )并且心脏的死亡(3.4%对1.0%,所有 P0.01 )比在控制在肾的不足组是显著地更高的组。为有中等肾的不足的病人, drug-eluting stent 培植显著地减少了死亡的所有原因(5.3%对10.9%, P0.05 )并且主要心脏的不利事件的出现( 15.1%vs 24.6%, P0.05 )与中等肾的不足是的赤裸的金属 stents.Conclusions 相比,与冠的动脉疾病和 drug-eluting stents 的使用在病人在一种总线标准以后影响死亡的一个重要临床的因素应该是为在 s | ZHANG Rui-yan NI Jing-wei ZHANG Jian-sheng HU Jian YANG Zhen-kun ZHANG Qi LUE An-kang SHEN Wei-feng | 2006 | Chinese Medical Journal2006，，14： | 23 |
| 18 | Impact of admission creatinine level on clinical outcomes of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stent implantation显示文摘收到了主要经皮的冠的干预(一种总线标准)的有尖锐圣举起心肌的梗塞( STEMI )和肾的机能障碍( RD )的病人的背景预后充分没在 era.This 学习试图在病人在短期的结果上评估承认浆液 creatinine 水平的影响的 drug-eluting stent ( DES )被调查与经历 基于DES 的主要 PCI.Methods 的尖锐 STEMI ,有 DES 培植的主要一种总线标准在 12 个小时以内在 619 个连续 STEMI | ZHANG Qi ZHANG Rui-yan SHEN Jie ZHANG Jian-sheng HU Jian YANG Zheng-kun ZHANG Xian ZHENG Ai-fang SHEN Wei-feng | 2008 | Chinese Medical Journal2008，，23： | 22 |
| 19 | Telomere and telomerase in the initial stage of immortalization of esophageal epithelial cell显示文摘AIM: To search for the biomarker of cellular immortalization,the telomere length, telomerase activity and its subunits incultured epithelial cells of human fetal esophagus in theprocess of immortalization.METHODS: The transgenic cell line of human fetalesophageal epithelium (SHEE) was established with E6 E7genes of bt man papillomavirus (HPV) type 18 in ourlaboratory. Morphological phenotype of cultured SHEE cellsfrom the 6th to 30th passages, was examined by phasecontrast microscopy, the telomere length was assayed bySouthern blot method, and the activity of telomerase wasanalyzed by telomeric repeat amplification protocol (TRAP).Expressions of subunits of telomerase, hTR and hTERT,were assessed by RT-PCR. DNA content in cell cycle wasdetected by flow cytometry. The cell apoptosis wasexamined by electron microscopy (EM) and TUNEL label.RESULTS: SHEE cells from the 6 th to 10 th passagesshowed cellular proliferation with a good differentiation.From the 12 th to the 16 th passages, many senescent andapoptotic cells appeared, and the telomere length sharplyshortened from 23 kb to 17 kb without expression of hTERTand telornerase activity. At the 20 th passage, SHEE cellsovercame the senescence and apoptosis and restored theirproliferative activity with expression of telomerase andhTERT at low levels, but the telomere length shortenedcontinuously to the lowest of 3 kb. After the 30 th passagecells proliferation was restored by increment of cells at S andG2M phase in the cell cycle end telomerase activity expressedat high levels and with maintenance of telomere length.CONCLUSION: At the early stage of SHEE cells, telomeresare shortened without expression of telomerase and hTERTcausing cellular senescence and cell death. From the 20 thto the 30 th passages, the activation of telomerase andmaintenance of telomere length show a progressive processfor immortalization of esophageal epithelial cells. Theexpression of telomerase may constitute a biomarker fordetection of immortalization of cells. | Zhong-Ying Shen Li-Yan Xu Wei-Jia Cai Min-Hua Chen Jian Shen,Department of Tumor Pathology,Medical College of Shantou University,Shantou 515031,Guangdong Province,China En-Min Li,Department of Biochemistry and Molecular Biology,Medical College of Shantou University,Shantou 515031,Guangdong Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China | 2002 | World Journal of Gastroenterology2002，8，2： | 21 |
| 20 | Characteristics, Management, and Outcomes of Acute Heart Failure in the Emergency Department: A Multicenter Registry Study with 1-year Follow-up in a Chinese Cohort in Beijing显示文摘 | Guo-Gan Wang Si-Jia Wang Jian Qin Chun-Sheng Li Xue-Zhong Yu Hong Shen Li-Pei Yang Yan Fu Ya-An Zheng Bin Zhao Dong-Min Yu Fu-Jun Qin De-Gui Zhou Ying Li Fu-Jun Liu Wei Li Wei Zhao Xin Gao Zheng Wang Ming Jin Hong Zeng Yi Li Guo-Xing Wang Hong Zhou Xiao-Lu Sun Peng-Bo Wang Kam-Sang Woo | 2017 | Chinese Medical Journal2017，，16： | 21 |
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