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| 1 | Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis显示文摘AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes. | Mehdi Mohamadnejad Mehrnaz Namiri Mohamad Bagheri Seyed Masiha Hashemi Hossein Ghanaati Narges Zare Mehrjardi Saeed Kazemi Ashtiani Reza Malekzadeh Hossein Baharvand | 2007 | World Journal of Gastroenterology2007，13，24： | 74 |
| 2 | Osteoarticular manifestations of human brucellosis:A review显示文摘Brucellosis is a common global zoonotic disease, which is responsible for a range of clinical manifestations. Fever, sweating and musculoskeletal pains are observed in most patients. The most frequent complication of brucellosis is osteoarticular involvement, with 10% to 85% of patients affected. The sacroiliac(up to 80%) and spinal joints(up to 54%) are the most common affected sites.Spondylitis and spondylodiscitis are the most frequent complications of brucellar spinal involvement. Peripheral arthritis, osteomyelitis, discitis, bursitis and tenosynovitis are other osteoarticular manifestations, but with a lower prevalence. Spinal brucellosis has two forms: focal and diffuse. Epidural abscess is a rare complication of spinal brucellosis but can lead to permanent neurological deficits or even death if not treated promptly. Spondylodiscitis is the most severe form of osteoarticular involvement by brucellosis, and can have single-or multifocal involvement. Early and appropriate diagnosis and treatment of the disease is important in order to have a successful management of the patients with osteoarticular brucellosis. Brucellosis should be considered as a differential diagnosis for sciatic and back pain, especially in endemic regions. Patients with septic arthritis living in endemic areas also need to be evaluated in terms of brucellosis. Physical examination, laboratory tests and imaging techniques are needed to diagnose the disease. Radiography, computed tomography, magnetic resonance imaging(MRI) and bone scintigraphy are imaging techniques for the diagnosis of osteoarticular brucellosis. MRI is helpful to differentiate between pyogenic spondylitis and brucellar spondylitis. Drug medications(antibiotics)and surgery are the only two options for the treatment and cure of osteoarticular brucellosis. | Seyed Mokhtar Esmaeilnejad-Ganji Seyed Mohammad Reza Esmaeilnejad-Ganji | 2019 | World Journal of Orthopedics2019，10，2： | 52 |
| 3 | Warpage and Shrinkage Optimization of Injection-Molded Plastic Spoon Parts for Biodegradable Polymers Using Taguchi, ANOVA and Artificial Neural Network Methods显示文摘In this study, it is attempted to give an insight into the injection processability of three self-prepared polymers from A to Z. This work presents material analysis, injection molding simulation, design of experiments alongside considering all interaction effects of controlling parameters carefully for green biodegradable polymeric systems, including polylactic acid(PLA), polylactic acid-thermoplastic polyurethane(PLA-TPU) and polylactic acid-thermoplastic starch(PLA-TPS). The experiments were carried out using injection molding simulation software Autodesk Moldflow?in order to minimize warpage and volumetric shrinkage for each of the mentioned systems. The analysis was conducted by changing five significant processing parameters, including coolant temperature, packing time, packing pressure, mold temperature and melt temperature. Taguchi's L27(35) orthogonal array was selected as an efficient method for design of simulations in order to consider the interaction effects of the parameters and reduce spurious simulations. Meanwhile, artificial neural network(ANN) was also used for pattern recognition and optimization through modifying the processing conditions. The Taguchi coupled analysis of variance(ANOVA) and ANN analysis resulted in definition of optimum levels for each factor by two completely different methods. According to the results, melting temperature, coolant temperature and packing time had significant influence on the shrinkage and warpage. The ANN optimal level selection for minimization of shrinkage and/or warpage is in good agreement with ANOVA optimal level selection results. This investigation indicates that PLA-TPU compound exhibits the highest resistance to warpage and shrinkage defects compared to the other studied compounds. | Erfan Oliaei Behzad Shiroud Heidari Seyed Mohammad Davachi Mozhgan Bahrami Saeed Davoodi Iman Hejazi Javad Seyfi | 2016 | Journal of Materials Science & Technology2016，32，8： | 26 |
| 4 | Eosinophilic gastroenteritis presenting as small bowel obstruction: A case report and review of the literature显示文摘Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract. Recently, the authors experienced a case of eosinophilic gastroenteritis presenting as small bowel obstruction. A 51-year old woman was admitted to our hospital complaining of abdominal pain and vomiting. Physical examination revealed a distended abdomen with diffuse tenderness. Complete blood count showed mild leukocytosis without eosinophilia. Computed tomography confirmed a dilatation of the small intestine with ascites. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Segmental resection of the ileum and end to end anastomosis were performed. Histologically, there was a dense infiltration of eosinophils throughout the entire thickness of ileal wall and eosinophilic enteritis was diagnosed. The patient recovered well, and was free from gastrointestinal symptoms at the time when we reported her disease. | Min Young Yun Young Up Cho In Suh Park Sun Keun Choi Sei Joong Kim Seok Hwan Shin Kyung Rae Kim | 2007 | World Journal of Gastroenterology2007，13，11： | 19 |
| 5 | Abiotic degradation of four phthalic acid esters in aqueous phase under natural sunlight irradiation显示文摘Abiotic degradability of four phthalic acid esters(PAEs) in the aquatic phase was evaluated over a wide pH range 5-9.The PAE solutions in glass test tubes were placed either in the dark and under the natural sunlight irradiation for evaluating the degradation rate via hydrolysis or photolysis plus hydrolysis,respectively,at ambient temperature for 140 d from autumn to winter in Osaka,Japan.The effciency of abiotic degradation of the PAEs with relatively short alkyl chains,such as butylbenzyl phthalate(BBP) and di-n-butyl phthalate(DBP),at neutral pH was significantly lower than that in the acidic or alkaline condition.Photolysis was considered to contribute mainly to the total abiotic degradation at all pH.Neither hydrolysis nor photolysis of di-ethylhexyl phthalate(DEHP) proceeded significantly at any pH,especially hydrolysis at neutral pH was negligible.On the other hand,the degradation rate of di-isononyl phthalate(DINP) catalyzed mainly by photolysis was much higher than those of the other PAEs,and was almost completely removed during the experimental period at pH 5 and 9.As a whole,according to the half-life(t1/2) obtained in the experiments,the abiotic degradability of the PAEs was in the sequence:DINP(32-140 d) > DBP(50-360 d),BBP(58-480 d) > DEHP(390-1600 d) under sunlight irradiation(via photolysis plus hydrolysis).Although the abiotic degradation rates for BBP,DBP,and DEHP are much lower than the biodegradation rates reported,the photolysis rate for DINP is comparable to its biodegradation rate in the acidic or alkaline condition. | Ruttapol Lertsirisopon Satoshi Soda Kazunari Sei Michihiko Ike | 2009 | Journal of Environmental Sciences2009，21，3： | 18 |
| 6 | A modified failure criterion for transversely isotropic rocks显示文摘A modified failure criterion is proposed to determine the strength of transversely isotropic rocks. Mechanical properties of some metamorphic and sedimentary rocks including gneiss, slate, marble, schist,shale, sandstone and limestone, which show transversely isotropic behavior, were taken into consideration. Afterward, introduced triaxial rock strength criterion was modified for transversely isotropic rocks.Through modification process an index was obtained that can be considered as a strength reduction parameter due to rock strength anisotropy. Comparison of the parameter with previous anisotropy indexes in literature showed reasonable results for the studied rock samples. The modified criterion was compared to modified Hoek-Brown and Ramamurthy criteria for different transversely isotropic rocks. It can be concluded that the modified failure criterion proposed in this study can be used for predicting the strength of transversely isotropic rocks. | Omid Saeidi Vamegh Rasouli Rashid Geranmayeh Vaneghi Raoof Gholami Seyed Rahman Torabi | 2014 | Geoscience Frontiers2014，5，2： | 16 |
| 7 | Efficacy of premedication with activated Dimethicone or N-acetylcysteine in improving visibility during upper endoscopy显示文摘AIM:To assess the efficacy of N-acetylcysteine(NAC) and activated Dimethicone in improving endoscopic mucosal visibility.METHODS:A total of 148 patients were randomly allocated into four groups to receive one of the following premedications:group A:100 mL water alone;group B:activated Dimethicone plus water(up to 100 mL);group C:NAC plus water(up to 100 mL);and group D:activated Dimethicone and NAC plus water(up to 100 mL).A single endoscopist blinded to the patients group assessed the gastric mucosal visibility scores(range 1-4) at four sites.The sum of the scores from the four sites was considered as the total mucosal visibility score(TMVS).RESULTS:The patients in group B showed a significantly lower TMVS than those of groups A and C(P < 0.001).The TMVS in patients of group D was significantly lower than that of groups A and C(P < 0.001).The TMVS did not significantly differ between groups B and D(P > 0.05).The difference between TMVS of groups C and A was not significant(P > 0.05).CONCLUSION:Premedication with activated Dimethicone 20 min prior to the upper endoscopy leads to the best visibility.NAC does not improve visualization by itself. | Seyed Mohammad Kazem Hosseini Asl Gholam Reza Sivandzadeh | 2011 | World Journal of Gastroenterology2011，17，37： | 15 |
| 8 | Comparison of different diagnostic methods in infants with Cholestasis显示文摘AIM: To evaluate different methods in differentiating idiopathic neonatal hepatitis from biliary atresia. METHODS: Sixty-five infants with cholestatic jaundice and final diagnosis of idiopathic neonatal hepatitis and biliary atresia were studied prospectively from September 2003 to March 2006. A thorough history and physical examination were undertaken and the liver enzymes were examined. All cases underwent abdominal ultrasonography, hepatobiliary scintigraphy, and percutaneous liver biopsy. The accuracy, sensitivity, specificity and predictive values of these various methods were compared. RESULTS: There were 34 girls and 31 boys, among them 46 subjects had idiopathic neonatal hepatitis (age, 61 ± 17 d) and 19 had biliary atresia (age, 64 ± 18 d). The mean age at onset of jaundice was significantly lower in cases of biliary atresia when compared to idiopathic neonatal hepatitis cases (9 ± 13 d vs 20 ± 21 d; P = 0.032). The diagnostic accuracy of different methods was as follows: liver biopsy, 96.9%; clinical evaluation, 70.8%; ultrasonography, 69.2%; hepatobiliary scintigraphy, 58.5%; and liver enzymes, 50.8%.CONCLUSION: Our results indicate that clinical evaluation by an experienced pediatric hepatologist and a biopsy of the liver are considered as the most reliable methods to differentiate idiopathic neonatal hepatitis and biliary atresia. | Seyed Mohsen Dehghani Mahmood Haghighat Mohammad Hadi Imanieh Bita Geramizadeh | 2006 | World Journal of Gastroenterology2006，12，36： | 14 |
| 9 | 针刀松解法对第3腰椎横突综合征大鼠下丘脑前阿黑皮素mRNA、前脑啡肽原mRNA表达的影响显示文摘目的:探讨针刀松解法治疗第3腰椎横突综合征的部分中枢镇痛机制。方法:SD雄性大鼠24只,随机分为正常组、模型组、针刀组及电针组。采用左侧第3腰椎横突尖部埋置明胶海绵法建立第3腰椎横突综合征模型,针刀组和电针组分别给予针刀松解和电针左侧'肾俞''腰阳关'治疗。应用原位杂交方法检测大鼠下丘脑前阿黑皮素(POMC)mRNA、前脑啡肽原(PPE)mRNA阳性细胞的表达。结果:造模后大鼠下丘脑POMC mRNA、PPE mRNA的阳性细胞表达较正常组增多(P<0.01),针刀组和电针组大鼠下丘脑POMC mRNA、PPE mRNA阳性细胞表达较模型组进一步增多(P<0.01)。结论:针刀松解法与电针可能通过促进下丘脑POMC mRNA、PPE mRNA的表达,参与其镇痛过程。 | 郭长青 曹榕娟 孙红梅 Seyed Javad Mojtabavi 马惠芳 吴海霞 许红 李晓泓 刘乃刚 张义 岳利锋 乔晋琳 陈占禄 | 2010 | 针刺研究2010，35，5： | 13 |
| 10 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 11 | Chest injury in victims of Bam earthquake显示文摘客观:为了分析损伤的数据,有在欺骗的地震的胸的损害的病人为更好在主要地震理解胸的损害的类型和后果承认了到医药科学(弦音器) 的德黑兰大学的医院。方法:登记 6 的 AfterBam 地震。5 在 Richter 上可伸缩, 526 个损伤病人进入弦音器的医院。在之中“他们, 53 个病人支撑了胸的损害。结果:这个组由 21females (39.6%) 和 32 男性(60.4%) 组成。十五个病人(28.3%) 孤立胸损害。Ribfracture (36.4%) 是在我们的病人的最普通的损害, haemo/pneumothorax (25.5%) 列在后面。表面的损害是最普通的伴随损害。有胸损害的多重损伤的病人与孤立的胸损害(P=0.003 ) 有更高的损害严厉分数(ISS ) 对病人。结论:胸墙损害和 haemo/ 气胸在地震的幸存牺牲品包括损害的一个可观的数字。因而,这些病人的多数能与观察或试管 thoracostomy 被对待。我们应该训练并且装备健康工人和救援队的成员在这块地里对待并且设法这些病人。 | Seyed Mohammad Ghodsi Moosa Zargar Ali Khaji Mojgan Karbakhsh | 2006 | Chinese Journal of Traumatology2006，9，6： | 13 |
| 12 | Novel cobalt(Ⅱ) complexes of amino acids-Schiff bases catalyzed aerobic oxidation of various alcohols to ketones and aldehyde显示文摘Two cobalt(Ⅱ) complexes 1 and 2 of Schiff bases derived from amino acids were synthesized and used for oxidation of benzyl alcohol with molecular oxygen at different conditions of pH,solvent,temperature and complex/alcohol molar ratio to optimize reaction conditions and to evaluate the catalytic efficiency of new cobalt Schiff base complexes.Under obtained optimum conditions,various alcohols were oxidized to corresponding aldehydes and ketones. | Seyed Mohammad Seyedi Reza Sandaroos Gholam Hossein Zohuri | 2010 | Chinese Chemical Letters2010，21，11： | 13 |
| 13 | Ankylosing spondylitis: A state of the art factual backbone显示文摘Ankylosing spondylitis(AS) is a chronic inflammatory disease that affects 1% of the general population. As one of the most severe types of spondyloarthropathy, AS affects the spinal vertebrae and sacroiliac joints, causing debilitating pain and loss of mobility. The goal of this review is to provide an overview of AS, from the pathophysiological changes that occur as the disease progresses, to genetic factors that are involved with its onset. Considering the high prevalence in the population, and the debilitating life changes that occur as a result of the disease, a strong emphasis is placed on the diagnostic imaging methods that are used to detect this condition, as well as several treatment methods that could improve the health of individuals diagnosed with AS. | Mohammad Ghasemi-rad Hosam Attaya Emal Lesha Andrea Vegh Tooraj Maleki-Miandoab Emad Nosair Nariman Sepehrvand Ali Davarian Hamid Rajebi Abdolghader Pakniat Seyed Amirhossein Fazeli Afshin Mohammadi | 2015 | World Journal of Radiology2015，7，9： | 13 |
| 14 | Clinical features of hepatopulmonary syndrome in cirrhotic patients显示文摘瞄准:评估频率,临床并且帕拉肝肺症候群(HPS ) 并且到的临床的特征在伊朗在病人在这症候群的诊断决定他们的预兆的价值。方法:54 个肝脏硬化症的病人经历了对比由二位心脏病专家检测肺内、心内的分流的提高的回响心动描记法。动脉的血氧, O (2 ) 坡度(A-a ) 和正统说法被气体(ABG ) 测试的动脉的血测量。为 HPS 的诊断标准积极的病人被定义为表明肺内的动脉的膨胀的临床的 HPS 盒子和那些,但是另外的标准(动脉的血血氧不足) 都没被定义为 lHPS 盒子。HPS 频率,敏感,积极、否定的预兆的价值临床并且帕拉临床的特征被学习。结果:十(18.5%) 并且七(13%) 盒子分别地有临床、无临床症状的 HPS。最普通的病原学是肝炎 B。呼吸困难(100%) 和青紫(90%) 是最流行的临床的特征。呼吸困难并且打分别地是最敏感、特定的临床的特征。没有重要关系被发现在之间 HPS 和脾大,腹水,浮肿,黄疸,尿少,和并行的静脉。HPS 在肝炎 B 是更流行的。PaO (2 )<
70 并且动脉牙槽的坡度在 HPS 病人有最高的敏感。正统说法特性是 100% 。结论:与 75% 的否定预兆的价值(NPV ) 与 75% 的积极预兆的价值(PPV ) 和呼吸困难打是在 HPS 的诊断的最好的临床的因素症候群。PaO (2 )<
70 并且 P (A-a ) O (2 )>
30 并且他们的和,是在 HPS 病人的最珍贵的否定、积极的预兆的价值。 | Amir Houshang MohammadAlizadeh Seyed Reza Fatemi Vahid Mirzaee Manoochehr Khoshbaten Bahman Talebipour Afsaneh Sharifian Ziba Khoram Mohammad Reza Zali Farhad Haj-sheikh-oleslami MasoomehGholamreza-shirazi | 2006 | World Journal of Gastroenterology2006，12，12： | 12 |
| 15 | New insights of Helicobacter pylori host-pathogen interactions: The triangle of virulence factors, epigenetic modifications and non-coding RNAs显示文摘Helicobacter pylori(H. pylori) is a model organism for understanding host-pathogen interactions and infection-mediated carcinogenesis. Gastric cancer and H. pylori colonization indicates the strong correlation. The progression and exacerbation of H. pylori infection are influenced by some factors of pathogen and host. Several virulence factors involved in the proper adherence and attenuation of immune defense to contribute the risk of emerging gastric cancer, therefore analysis of them is very important. H. pylori also modulates inflammatory and autophagy process to intensify its pathogenicity. From the host regard, different genetic factors particularly affect the development of gastric cancer. Indeed, epigenetic modifications, Micro RNA and long non-coding RNA received more attention. Generally, various factors related to pathogen and host that modulate gastric cancer development in response to H. pylori need more attention due to develop an efficacious therapeutic intervention. Therefore, this paper will present a brief overview of host-pathogen interaction especially emphases on bacterial virulence factors, interruption of host cellular signaling, the role of epigenetic modifications and non-coding RNAs. | Farzam Vaziri Samira Tarashi Abolfazl Fateh Seyed Davar Siadat | 2018 | World Journal of Clinical Cases2018，6，5： | 12 |
| 16 | Scour and flow field around a spur dike in a 90° bend显示文摘Spur dike is an important element in river training that creates rapid variations in flow field, sediment transport and bed topography. The mechanism of flow and sediment transport in a channel bend is very complex, especially when a spur dike is constructed in a bend. Most of previous investigations on flow behavior and scour around spur dike were carried out in straight channels. In this paper results of experiments on flow field and scour around a spur dike in a 90 degree channel bend are presented. Sand with uniform grain size was used as the bed material. Experiments were conducted for different locations and different lengths of spur dikes at the bend with different values of discharge. The three dimensional flow fields around a spur dike were investigated. The maximum depth of scour was correlated to the Froude numbers, lengths and the locations of spur dike in the bend. | Majid FAZLI Masoud GHODSIAN Seyed Ali Akbar Salehi NEYSHABOURI | 2008 | International Journal of Sediment Research2008，23，1： | 11 |
| 17 | Cyclic vomiting syndrome in children: Experience with 181 cases from southern Iran显示文摘AIM: To evaluate the clinical presentation, response to prophylactic therapy and outcome of children with cyclic vomiting syndrome (CVS) in Shiraz, Iran.METHODS: During a period of 11 years (March 1994 to March 2005), 181 consecutive children with a final diagnosis of CVS were evaluated, treated and followed in our center. Patients were randomized to receive either amitriptyline or propranolol as prophylactic treatments. RESULTS: There were 88 boys and 93 girls with mean age of onset of symptoms of 4.9 ± 3.3 years (range, neonatal period to 14 years), the mean age at final diagnosis was 6.9 years (range, 1.5 to 14), and the mean duration between the onset of the first attack and the final diagnosis of CVS was 2 ± 1.81 years (range, 1/6 to 8). The mean duration of each attack was 4.26 days (range, from few hours to 10 d) and the mean interval between the attacks was 1.8 mo (range, 1 wk to 12 mo). The time of onset of the attacks was midnight to early morning in about 70% of cases. Amitriptyline was effective in 46 out of 81 (56%) patients (P < 0.001). Propranolol appeared to have a superior action and was effective in 74 out of 83 (92%) patients (P < 0.0001).CONCLUSION: There is a significant lag time between the onset of clinical symptoms and the final diagnosis of CVS in our area. In patients with typical clinical presentations of CVS, who are examined by an experienced physician, invasive workup is not necessary. Propranolol appears more effective than amitriptyline for prophylactic use in children with CVS. | Mahmood Haghighat Seyed Mohammad Rafie Seyed Mohsen Dehghani Gholam Hossein Fallahi Marzieh Nejabat | 2007 | World Journal of Gastroenterology2007，13，12： | 11 |
| 18 | Remote ischemic conditioning approach for the treatment of ischemic stroke显示文摘Stroke is the leading cause of disability and death in North America.There has been growing interest in identifying neuroprotective strategies to reduce ischemic burden in patients with acute ischemic stroke.However,despite extensive clinical trials,no neuroprotective agent has been found for prevention of ischemic damage.Remote ischemic preconditioning(RIC)is a promising non-invasive strategy that has been proven to provide renal and cardioprotection and has recently found to have a potential broad application in the treatment of neurovascular disease,which has bee linked to its possible effects on the release and activation of endogenous neuroprotective substances against the ischemia/reperfusion injuries in experimental studies.This endogenous neuroprotection might vaccinate neural tissues against effects of acute IR following primary infarction insult.Regardless of the method of RIC administration,through manual or automated blood pressure cuff,RIC procedure is inexpensive and easy to use.Based on the experimental and clinical data,application of RIC avoids possible adverse effects and interactions associated with chemical pharmacological agents.In previous clinical studies RIC was safe and associated with only minor transient adverse effects in few cases,including petechia and minor limb pain,which were mostly resolved shortly after completing the treatment. | Seyed Mohammad Seyedsaadat David F.Kallmes Waleed Brinjikji | 2020 | Neural Regeneration Research2020，15，6： | 11 |
| 19 | Effect of ultrasonic irradiation on rheological properties of asphaltenic crude oils显示文摘In this work, the rheological changes of several crude oil samples exposed to ultrasonic waves for different time intervals in addition to the effect of temperature on viscosity behavior of heavy crude oils were investigated using a series of steady shear flow and oscillatory tests. The colloidal structural evolutions of flocs in oil samples were illustrated by analysis of the size distribution of flocculated asphaltene particles (confocal microscopy tests). The rheological investigations indicate that the ultrasonic irradiation dissolved heavy components in crude oil. After ultrasonic treatment, the Kouh-e-Mond crude oil was found to be pseudoplastic. In addition, confocal microscopy confirms that there was an optimum duration for ultrasonic irradiation, at which the viscosity and flocculation rate of asphaltenic crude oils reduced to the minimum values. The optimum was found to be approximately 40 min for the Kouh-e-Mond crude oil. Experimental results illustrate that the ultrasonic irradiation could disaggregate heavy colloid components in crude oil, and breakdown of asphaltene molecules would only occur in a specific time interval of irradiation. Also according to the temperature sweep test, the oil temperature rise caused by ultrasonic irradiation was not the main reason for rheological changes of the crude oil and this alteration may be due to physical and chemical phenomena induced by sonication in crude oil. | MOUSAVI Seyed Mohammadreza RAMAZANI Ahmad NAJAFI Iman DAVACHI Seyed Mohammad | 2012 | Petroleum Science2012，9，1： | 10 |
| 20 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
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