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| 1 | Dimensions of hepatocellular carcinoma phenotypic diversity显示文摘Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying 'clinically-friendly' molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the remaining challenges to translate our cognitive corpus into patient diagnosis and allocation to therapeutic options. | Romain Désert Natalia Nieto Orlando Musso | 2018 | World Journal of Gastroenterology2018，24，40： | 3 |
| 2 | The preventive effect on bone loss of 50-Hz,1-mT electromagnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D D(u)z MZ | | 0，，06： | 1 |
| 3 | Production of Ba(Znw3 Nbz/3 ) Oa ceramic by coprecipitation显示文摘 | MERGEN A SERT D | 2012 | Materials Characteri- tation2012，63，： | 1 |
| 4 | The preventive effect on boneloss of50-Hz,l-mT electromagnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D Dtiz MZ | 2012 | J BoneMiner Metab2012，20，34： | 1 |
| 5 | The preventive effect on bone loss of 50 Hz,1 mT electromagnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D Duz MZ | 2002 | J Bone Miner Metab2002，20，6： | 1 |
| 6 | Hypotension art érielle après administration intraveineuse et orale de paracétamol显示文摘 | Déserts M D D Nguyen B V Giacardi C | 2010 | Retour Au Numéro2010，29，4： | 1 |
| 7 | Treament of erythropoietin-induced pure red cell aplasia: a retrospective study显示文摘 | Verhels t D Ros sert J Casadevall N | 2004 | Lancet2004，363，9423： | 1 |
| 8 | The Drevenrive effect on bone loss of 50-Hz, 1-mT electromagnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D Duz MZ | 2002 | J Bone Miner Metab2002，20，6： | 1 |
| 9 | The preventive effect on bone loss of 50-Hz, 1-mT electromagnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D Duz MZ | 2002 | J Bone Miner Metab2002，20，6： | 1 |
| 10 | Characterization of the permeability of the blast furnace lowerpart 显示文摘 | NEGRO P PETIT C URVOY A SERT D PIERRET H | 2001 | Revue de Metallurgie-Cahiers D''InformationsTechniques2001，98，6： | 1 |
| 11 | The preventive effect on bone lossof 50 Hz, ImT electrom agnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D Duz MZ | 2002 | BoneMiner Metab2002，20，6： | 1 |
| 12 | Effects of vacuum packing on eggshell microbial activity and egg quality in table eggs under different storage temperatures显示文摘 | AYGUN A SERT D | 2013 | J Sci Food Agr2013，，93： | 1 |
| 13 | Association of refractory com- plex partial seizures with a polymorphism of ApoE genotype 显示文摘 | Spori08 D Sert!c J Henigsberg N | 2005 | J Cell Mol Med2005，9，3： | 1 |
| 14 | Effects of vacuum packing on eggshell mi-crobial activity and egg quality in table eggs under differentstorage temperatures显示文摘 | AYGUN A SERT D | 2013 | J Sci Food Agric2013，，4： | 1 |
| 15 | Production of nanoscale Ba(Zni/3Nb2/3)03 microwave dielectric ceramics by polymerised complex method 显示文摘 | SERT D MERGEN A | 2009 | J Alloys Compd2009，482，12： | 1 |
| 16 | Production of Ba(Zni/3Nb2/3)〇3 ceramic by coprecipitation 显示文摘 | MERGEN A SERT D | 2011 | Mater Characterization2011，482，： | 1 |
| 17 | Effect of ultrasonic treat- ment on reduction of Esherichia coli ATCC 25922 and egg quality parameters in experimentally contaminated hens' shell eggs显示文摘 | Sert D Aygun A Torlak E | 2013 | Journal of the Science of Food and Agriculture2013，93，12： | 1 |
| 18 | Temporary cardiac pacemaker in the treatment of junctional rhythm and hypotension due to imipramine intoxication显示文摘 | Sert A Aypar E Odabas D | 2011 | Pediatric cardiol2011，32，4： | 1 |
| 19 | Inactivation of Cronobacter by gaseous ozone in milk powders with different fat contents显示文摘 | TORLAK E SERT D | 2013 | International Dairy Journal2013，32，2： | 1 |
| 20 | The preventive effect on bone loss of 50Hz,lmT electromagnetic field in ovariectomized rats显示文摘 | Sert C Mustafa D Duz MZ | 2002 | J Bone Miner Metab2002，20，6： | 1 |
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