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| 1 | Spontaneous calcaneal fracture in patients with diabetic foot ulcer: Four cases report and review of literature显示文摘Spontaneous calcaneal fractures in diabetic patients without obvious trauma may occur, sometimes accompanying diabetic foot ulcers. In the current study we report four cases who were hospitalized for diabetic foot ulcer with concomitant calcaneal fractures. There were four diabetic patients(one type 1 and three type 2) who registered with diabetic foot ulcers with coexisting calcaneal fractures, all of which were classified as Type A according to Essex Lopresti Calcaneal Fracture Classification. Two of the patients with renal failure were in a routine dialysis program, as well as vascular compromise and osteomyelitis in all of the patients. The diabetic foot ulcer of the 61 years old osteoporotic female patient healed with local debridement, vacuum assisted closure and then epidermal growth factor while the calcaneal fracture was then followed by elastic bandage. In two patients could not prevent progression of diabetic foot ulcers and calcaneal fractures to consequent below-knee amputation. The only patient with type 1 diabetes mellitus improved with antibiotic therapy and split thickness skin grafting, while the calcaneal fracture did not heal. In the current study we aimed to emphasize the spontaneous calcaneal fractures as possible co-existing pathologies in patients with diabetic foot ulcers. After all the medical treatment, amputation below knee had to be performed in 2 patients. It should be noted that other accompanying conditions such as impaired peripheral circulation, osteomyelitis, chronic renal failure, and maybe osteoporosis is a challenge of the recovery of calcaneal fractures and accelerate the progress to amputation in diabetic patients. | Mehtap Evran Murat Sert Tamer Tetiker Gamze Akku? ?mer Sunkar Bi?er | 2016 | World Journal of Clinical Cases2016，4，7： | 7 |
| 2 | Efficient adsorption of Th(Ⅳ)from aqueous solution by modified SBA-15 mesoporous silica显示文摘A very effective adsorbent for thorium has been obtained by modification of Santa Barbara Amorphous(SBA-15) using the chelating agent thenoyltrifluoroacetone(TTA).The prepared adsorbent(SBA-15-TTA) was characterized using scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),surface area,porosity,and zeta potential analyses.We investigated the factors affecting Th(IV) adsorption on TTA-SBA-15,such as initial p H,contact time,temperature,and initial metal concentration.The effective initial p H for adsorption was found to be 4.The binding sites on TTA-SBA-15 adsorbent were saturated using an initial Th(IV) concentration of 100 mg L-1.The Dubinin–Radushkevich isotherm suggested a strong chemical interaction between adsorbent and adsorbate.Contact time and temperature had no significant effect on the adsorption.Therefore,the studies show that TTA-SBA-15 is a promising adsorbent to treat Th(IV)-contaminated effluents. | Mutlu Gok Senol Sert Gulcin Ozevci Meral Eral | 2018 | Nuclear Science and Techniques2018，29，7： | 3 |
| 3 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 4 | Dimensions of hepatocellular carcinoma phenotypic diversity显示文摘Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying 'clinically-friendly' molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the remaining challenges to translate our cognitive corpus into patient diagnosis and allocation to therapeutic options. | Romain Désert Natalia Nieto Orlando Musso | 2018 | World Journal of Gastroenterology2018，24，40： | 3 |
| 5 | 幽门螺杆菌在胰岛素抵抗中的效应显示文摘Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylori has been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. Sixty-three patients were enrolled in the study. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73±.1.1inthe H. pylori-negative group, whereas it was 2.56 ±.1.54 in the H. pylori-positive group (P < 0.05). This study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance. | Aydemir S. Bayraktaroglu T. Sert M. 赵天智 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，3： | 2 |
| 6 | Correlation of Volume Control Parameters With Health-Related Quality of Life in Renal Transplant Patients显示文摘 | Colak H Sert I Ekmekci C | 2015 | Transplant Proc2015，，01： | 1 |
| 7 | Lanthanum (Ⅲ)-catalyzed degradation of cellulose at 250 ℃ 显示文摘 | SERT K-I SAKAKI T SHIBATA M INOUE Y ISHIDA H | 2002 | Bioresour Technol2002，81，3： | 1 |
| 8 | Obstructive sleep apnea:Implications for cardiac and vascular disease显示文摘 | Lopez-Jimenez F Sert Kuniyoshi FH Gami A | 2008 | Chest2008，133，3： | 1 |
| 9 | Serum placental growth factor,vascular endothelial growth factor,soluble vascular endothelial growth factor receptor-1 and-2 levels in periodontal disease,and adverse pregnancy outcomes显示文摘 | Sert T Kirzioglu FY Fentoglu O | 2011 | J Periodontol2011，82，12： | 1 |
| 10 | Melatonin protects against pressure ulcer-induced oxidative injury of the skin and remote or- gans in rats显示文摘 | Sener G Sert G Ozer Sehirli A | 2006 | J Pineal Res2006，40，3： | 1 |
| 11 | Clinical report of 28 patients with Sheehan 's syndrome显示文摘 | Sert M Tetiker T Kirim S | 2003 | Endor J2003，50，3： | 1 |
| 12 | Evaluation of the Root Canal Configuration of the Mandibular and Maxillary Permanent Teeth by Gender in the Turkish Population显示文摘 | Sert S Bayirli GS | 2004 | J Endod2004，30，6： | 1 |
| 13 | Fractures,hydrothermal alterations and permeability in the SoultzEnhanced Geothermal System显示文摘 | Ledésert B Hebert R Genter A | 2010 | Comptes RendusGeoscience2010，342，7： | 1 |
| 14 | Approaches to distal humeral fractures in adults and comparison of treatment results显示文摘 | Ulusal AE Boz U Sert?z Z | 2006 | Acta Orthop Traumatol Turc2006，1，4： | 1 |
| 15 | Evaluation of the root canal con- figurations of the mandibular and maxillary per- manent teeth by gender in the Turkish population显示文摘 | Sert S Bayirli GS | 2004 | J Endod2004，30，6： | 1 |
| 16 | Identification and expansion of the tumorigenic lung cancer stem cell population 显示文摘 | Eramo A Lotti F Serte G | 2008 | Cell Death Differ2008，15，3： | 1 |
| 17 | The effect of head rotation on intraocular pressure in prone position:a randomized trial显示文摘 | Nuri Deniz M Erakgün A Sertz N | 2013 | Rev Bras Anesthesiol2013，63，2： | 1 |
| 18 | Wear behavior of different surface treated cam spindles显示文摘 | Sert H Canb A Arkan H | 2006 | Wear2006，，8： | 1 |
| 19 | MOFCA:Multi-objective fuzzy clustering algorithm for wireless sensor networks显示文摘 | Seyyit Alper Sert Hakan Bagci Adnan Yazici | 2015 | Applied Soft Computing2015，30，6： | 1 |
| 20 | Transient neurologieal symptoms after spinal anaesthesia with levobupivacaine 5 mg/ml or lidocaine 20 ms/ml显示文摘 | Gozdemir M Muslu B Sert H | 2010 | Acta Anaesthesiol Scand2010，54，1： | 1 |
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