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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Biomarkers of exposure to metal contamination and lipid peroxidation in the benthic fish Cathorops spixii from two estuaries in South America, Brazil 显示文摘 | zevedo J S Serafim A Company R | 2009 | Ecotoxicology2009，18，8： | 1 |
| 3 | Effect of cadmium, copper and mercury on antioxidant enzyme activities and lipid peroxidation in the gills of the hydrothermal vent mussel Bathymodiolus azoricus 显示文摘 | COMPANY R SERAFIM A BEBIANNO M J | 2004 | Marine Environmental Research2004，58，25： | 1 |
| 4 | Biomarkers of exposure to metal contamination and lipid peroxidation in the benthic fish Cathorops spixii from two estuaries in South America, Brazil显示文摘 | Azevedo J S Serafim A Company R | 2009 | Ecotoxicology2009，18，8： | 1 |
| 5 | Comparison of metallothionein induction in response to cadmium in the gills of the bivalve molluscs Mytilus galloprovincialis and Ruditapes decussates 显示文摘 | Bebianno M J Serafim M A | 1998 | The Science of the Total Environment1998，214，： | 1 |
| 6 | Comparison of metallothionein induction in response to cadmium in the gills of the bivalve molluscs Mytilus galloprovincialis and Ruditapes decussates显示文摘 | Bebianno M J Serafim M A | 1998 | Science of the Total Environment1998，214，13： | 1 |
| 7 | In vitro differentiation of male mouse embryonic stem cells into both presumptive sperm cells and oocytes 显示文摘 | Kerkis A Fonseca SA Serafim RC | 2007 | Cloning Stem Cells2007，9，4： | 1 |
| 8 | Response of antioxidant systems to copper in the gills of the clam Ruditapes decussates 显示文摘 | Geret F Serafim A Barreira L | 2002 | Marine Environmental Research2002，54，： | 1 |
| 9 | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding 显示文摘 | Paulo C Lemos Luisa S Serafim Maria A M Reis | 2006 | Journal of Biotechnology2006，122，： | 1 |
| 10 | Multi -biomarker responsesto estuarine habitat contamination in three fish species:Dicentrachus labrax,Solea senegalensis and Pomatoschistus microps显示文摘 | Maria V L Franca S Serafim A | 2011 | Aquatic Toxicology2011，102，： | 1 |
| 11 | Response of antioxidant system to coopering the gills of the clam Ruditapes decussates显示文摘 | Geret F Serafim A Barreira L | 2002 | Marine Environmental Research2002，543，3： | 1 |
| 12 | In vitro differentiation of male mouse embryonic stem cells into both presumptive sperm cells and oocytes显示文摘 | Kerkis A Fonseca SA Serafim RC | 2007 | Cloning Stem Cells2007，9，4： | 1 |
| 13 | Antioxidant enzyme activities,metallothineins and lipid peroxidation as biomarker in Ruditapes decussates显示文摘 | Geret F Serafim A Joao Bebianno M | 2003 | Ecotoxicology2003，12，： | 1 |
| 14 | The blood leukocyte count and its prognostic significance in severe head injury 显示文摘 | Aristedis R Serafim K Rovlias A | 2004 | Surgical Neurology2004，55，4： | 1 |
| 15 | Antioxidant enzyme activities,metallothioneins and lipid peroxidation as biomarkers in Ruditapes decussates显示文摘 | GERET F SERAFIM A BEBIANNO M J | 2003 | Ecotoxicology2003，12，1： | 1 |
| 16 | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submilted to aerobic dynamic feeding显示文摘 | Lemos P C Serafim S Maria A M Reis | 2006 | Journal of Bioteehnology2006，122，2： | 1 |
| 17 | Assessment ofinformatization for the dispensing of medications at a university hospital显示文摘 | Serafim S A Forster A C Simoes M J | 2010 | Clinics (Sao Paulo)2010，65，4： | 1 |
| 18 | The effect of cadmium on antioxidant responses and the susceptibility to oxidative stress in the hydrothermal vent mussel Bathymodiolus azoricus显示文摘 | Company R Serafim A Cosson R | 2006 | Mar Biol2006，148，： | 1 |
| 19 | Interstitial pressures on rock foundations of dams显示文摘 | Serafim J L Campo A D | 1965 | Journal of the Soil Mechanics and Foundations Division1965，91，： | 1 |
| 20 | Effect of cadmium on antioxidant enzyme activities and lipid peroxidation in the gills ofthe clam Ruditapes decussatus 显示文摘 | Geret F Serafim A Barreira L | 2002 | Biamarkers2002，7，3： | 1 |
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