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| 1 | 显示文摘 | Seim H Nieminen M Niinisto L | 1997 | Appl Surf Sci1997，112，： | 1 |
| 2 | Risk of incomplete pyloromyotomy and mucosal perforation in open and laparoscopic pyloromyotomy显示文摘 | Nigel Hall Simon Eaton Aaron Seims | 2014 | Pediatr Surg2014，，49： | 1 |
| 3 | Influence of mucinous component survival in colorectal adenocarcinoma:a multivariate analysis显示文摘 | Halvorsen T Seim E | 1988 | J ClinPathol1988，41，10： | 1 |
| 4 | Thermal behavior of a metal embedded fiber Bragg grating sensor显示文摘 | Xiao Chun Li Fritz Prinz John Seim | 2001 | Smart Material and Structure2001，10，4： | 1 |
| 5 | Democracy as a middle ground: A unified theory of development and political regimes显示文摘 | Anna Larsson Seim Stephen L. Parente | 2013 | European Economic Review2013，，： | 1 |
| 6 | High rate of fusion in sheep cervical spines following anterior interbody surgery with absorbable and non- absorbable implant devices显示文摘 | Slivka M A Speneiner D B Seim H B 3rd Welch W C Serhan H A Turner A S | 2006 | Spine2006，31，： | 1 |
| 7 | Catheterization of the subarachnoid space in rabbits using a Vascular Access Port显示文摘 | Tissot VPM Seim HR Tucker A | | 0，，： | 1 |
| 8 | Partial versus total splenectomy in children with hereditary spherocytosis显示文摘 | Seims AD Breckler FD Hardacker KD | 2013 | Surgery2013，154，4： | 1 |
| 9 | Price dis- crimination in service industries 显示文摘 | LAMBRECHT A SEIM K VILCASSIM N | 2012 | Marketing Letters2012，23，2： | 1 |
| 10 | Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation显示文摘Many mammals risk damage from oxidative stress stemming from frequent dives(i.e., cycles of ischemia/reperfusion and hypoxia/reoxygenation),high altitude and subterranean environments, or powered flight. Purine metabolism is an essential response to oxidative stress, and an imbalance between purine salvage and de novo biosynthesis pathways can generate damaging reactive oxygen species(ROS). Here, we examined the evolution of 117 purine metabolism-related genes to explore the accompanying molecular mechanisms of enhanced purine metabolism in mammals under high oxidative stress. We found that positively selected genes,convergent changes, and nonparallel amino acid substitutions are possibly associated with adaptation to oxidative stress in mammals. In particular, the evolution of convergent genes with c AMP and c GMP regulation roles may protect mammals from oxidative damage. Additionally, 32 genes were identified as under positive selection in cetaceans, including key purine salvage enzymes(i.e., HPRT1), suggesting improved re-utilization of non-recyclable purines avoid hypoxanthine accumulation and reduce oxidative stress. Most intriguingly, we found that six unique substitutions in cetacean xanthine dehydrogenase(XDH), an enzyme that regulates the generation of the ROS precursor xanthine oxidase(XO) during ischemic/hypoxic conditions, show enhanced enzyme activity and thermal stability and diminished XO conversion activity. These functional adaptations are likely beneficial for cetaceans by reducing radical oxygen species production during diving. In summary, our findings offer insights into the molecular and functional evolution of purine metabolism genes in mammalian oxidative stress adaptations. | Ran Tian Chen Yang Si-Min Chai Han Guo Inge Seim Guang Yang | 2022 | Zoological Research2022，43，2： | 1 |
| 11 | Carnitine metabolism and its regu-lation in microorganisms and mammals显示文摘 | Rebouche C J Seim H | 1998 | Annual Re-view of Nutrition1998，18，： | 1 |
| 12 | p H,hardness,and humic acid influence aluminum toxicity to rainbow trout(Oncorhynchus mykiss)in weakly alkaline waters显示文摘 | Gundersen D T Bustaman S Seim W K | 2011 | Canadian Journal of Fisheries and Aquatic Science2011，51，13： | 1 |
| 13 | The prevalence and cor- relates of urinary tract symptoms in Norwegian men: the HUNT study显示文摘 | SEIM A HOYO C OSTBYE T | 2005 | Bju Int2005，96，： | 1 |
| 14 | Tidal circulation and energy dissipation in a shallow, sinuous estuary显示文摘 | Harvey Seim Jackson Blanton Susan Elston | 2006 | Ocean Dynamics (-)2006，，3： | 1 |
| 15 | Effect of acute gastric dilatation on gastric myoelectic and motor activity in dog显示文摘 | Hall J A Solie T N Seim H B | 1999 | Am J Vet Res1999，60，5： | 1 |
| 16 | Causes of cancellations on the day of surgery at two major university hospitals显示文摘 | Seim AR Fagerhaug T Ryen SM | 2009 | Surg Innov2009，16，2： | 1 |
| 17 | High rate of fusion in sheep cervical spines following anterior in- terbody surgery with absorbable and nonabsorbable implant devi- ces显示文摘 | Slivka Michael A Spenciner David B Seim Howard B Ⅲ | 2006 | Spine2006，31，： | 1 |
| 18 | Effects of dietary yeast cell wallβ-glucans and MOS on performance,gut health,and salmon lice resistance in Atlantic salmon(Salmo salar)fed sunflower and soybean meal显示文摘 | Refstie S Baeverfjord G Seim R R | 2010 | Aquaculture2010，305，： | 1 |
| 19 | Electrocardiographic findings associated with very low calorie dieting 显示文摘 | Seim HC Mitchell JE Pomeroy C | 1995 | Int J Obes Relat Metab Disord1995，19，： | 1 |
| 20 | Effects of roal L-carnitine upplementation on in vivo Long-Chain fatty acid oxidation in healthy adults显示文摘 | Muller DM Seim H Kiess W | 2002 | Metabolism2002，51，11： | 1 |
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