|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | MRI-based measurement of hippocampal volume in patients with ccrnhat- related posttraumatic stress disorder显示文摘 | BREMNER J D RANDALL P SCOTT T M | 1995 | Am J Psychiatry1995，152，7： | 2 |
| 5 | The efficacy of spinosad against the western flower thrips,Frankliniella occidentalis,and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Jones T Scott D C Harris R | 2005 | Pest Manag Sci2005，61，： | 1 |
| 6 | Effect of thiouracil-induced hypothyroidism on the humoral immunity of new hampshire chickens 显示文摘 | Scott T Zijpp A V D Glick B | 1985 | Poultry Science1985，64，11： | 1 |
| 7 | A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia:a five-year follow-up显示文摘 | Turkington D Sensky T Scott J | | 0，，1： | 1 |
| 8 | A study on the interaction of xylanase and phytase enzymes in wheat-based diets fed to commercial white and brown egg laying hens 显示文摘 | Silversides F G Scott T A Korver D R | 2006 | Poultry Science2006，85，： | 1 |
| 9 | Total knee arthroplasty with the PFC system results at a minimum of ten years and survivorship analysis 显示文摘 | Schai P A Thornhill T S Scott R D | 1998 | J Bone Joint Surg Br1998，80，5： | 1 |
| 10 | In vivo tumor imaging using a near-infrared-labeled endostatin molecule显示文摘 | Citrin D Scott T Sproull M | 2004 | Int J Radiation Oncology Biol Phys2004，58，2： | 1 |
| 11 | Risks Of synchronous gastrointestinal Or biliary surgery with splenectomy for hematologic disease 显示文摘 | Mcaneny D Gtodek C P Scott T E | 1996 | Arch Surg1996，131，3： | 1 |
| 12 | A pilot-scale continuous-jet hydrate reactor显示文摘 | Phillip S Scott D M Patricia T S | | 0，，： | 1 |
| 13 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 14 | An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing 显示文摘 | BLANPIED T A SWANSON G T | 2001 | Jour of Neurosci2001，21，9： | 1 |
| 15 | Predicting subcellular localization via protein motif co-occurrence 显示文摘 | SCOTT M S THOMAS D Y HALLETT M T | 2004 | Genome Res2004，14，： | 1 |
| 16 | Sorption of hydrophobic pollutants in natural sediments显示文摘 | Karickhof S W Brown D S Scott T 1979 | 1979 | Water Res1979，13，： | 1 |
| 17 | The global de-cline of reptiles, d6j6 vu amphibians 显示文摘 | Gibbon J W Scott D E Ryan T J | 2000 | BioScience2000，50，8： | 1 |
| 18 | The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma 显示文摘 | Azuhata T Scott D Takamizawa S | 2001 | J Pediatr Surg2001，36，12： | 1 |
| 19 | The Role of Core Self-evaluations in the Coping Process显示文摘 | KAMMEYER-MUELLER J D JUDGE T A SCOTT B A | 2009 | Journal of Applied Psychology2009，94，1： | 1 |
| 20 | Chameleonic or consis- tent? A multilevel investigation of emotional labor variability and self-monitoring 显示文摘 | Scott B A Barnes C M Wagner D T | 2012 | Academy of management journal2012，55，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员