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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 3 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 4 | Development of coarsegrained facies in lacustrine rift basins, example from East of America 显示文摘 | Scholz C A Rosendahl B R Scott D L | 1990 | Geology1990，18，2： | 1 |
| 5 | Disappearance of patulin from apple juice fermented by Saccharomyces spp显示文摘 | HARWIG J SCOTT P M KENNEDY B P C | | 0，，01： | 1 |
| 6 | Field N2O, CO2 and CH4 fluxes in relation to tillage, compaction and soil quality in Scotland显示文摘 | Ball B C Scott A Parker J P | 1999 | Soil Tillage Res1999，53，： | 1 |
| 7 | The reproductive biology of Sclerpagesformosas (Maller Schlegel) ( Osteoglossomorpaha, Osteoglossidae) in Malaya, and morphology of its pituitary gland 显示文摘 | SCOTT D B C FULLER J D | 1976 | Journal of Fish Biology1976，8，1： | 1 |
| 8 | Dietary shift incorallivorous Drupella snails following a major bleachingevent at Koh Tao, Gulf of Thailand 显示文摘 | Hoeksema B W Scott C True J D | 2013 | Coral Reefs2013，32，2： | 1 |
| 9 | Macrolide and ketolide antibiotic separation by reversed phase high performance liquid chromatography显示文摘 | Lingerfelt B Scott C W | 1999 | J Pharm Biomed Anal1999，20，3： | 1 |
| 10 | Chameleonic or consis- tent? A multilevel investigation of emotional labor variability and self-monitoring 显示文摘 | Scott B A Barnes C M Wagner D T | 2012 | Academy of management journal2012，55，4： | 1 |
| 11 | Immunity and protection against Brucella abortus 显示文摘 | Golding B Scott DE Scharf 0 Huang LY Zaitseva M Lapham C Eller N Golding H | 2001 | Microbes Infect2001，3，1： | 1 |
| 12 | Field N2O, CO2 and CH4 fluxes in relation to tillage, compaction and soil quality in Scotland 显示文摘 | Ball B C Scott A Parker J P | 1999 | Soil & Tillage Research1999，53，： | 1 |
| 13 | Thyroid hormone acti-vates fibroblast growth factor receptor-1 in bone显示文摘 | Stevens D A Harvey C B Scott A J | 2003 | Mol Endocri-nol2003，17，9： | 1 |
| 14 | Surgical debride-ment ofcraniocervical necrotizing fasciitis : the window ofopportunity 显示文摘 | Hanna B C Delap T G Scott K | 2006 | J Laryngol Otol2006，120，8： | 1 |
| 15 | Procedural justice, and task performance: The mediating role of intrinsic motivation显示文摘 | ZAPATA-PHELAN C P COLQUITT J A SCOTT B A | 2009 | Organ- izational Behavior and Human Decision Processes2009，108，1： | 1 |
| 16 | Chloropicrin as a soil fumigant in forest nunes显示文摘 | David B S William A C and Scott A E | 1997 | The Forestry Chronicle1997，73，4： | 1 |
| 17 | Electricity gener- ation from cysteine in a microbial fuel cell 显示文摘 | Logan B E Murano C Scott K | 2005 | Water Res2005，39，： | 1 |
| 18 | Electricity genera- tion from cysteine in a microbial fuel cell显示文摘 | Logan B E Murano C Scott K | 2005 | Water Res2005，39，： | 1 |
| 19 | Design of Ultra-LowCost UHF RFID Tags for Supply Chain Applications显示文摘 | Rob G Cameron B Scott C | 2004 | IEEE Communications Magazine2004，，08： | 1 |
| 20 | Microfluidic chip for low-flow push-pull perfusion sampling in vivo with on-line analysis of amino acids 显示文摘 | NICHOLAS A C SCOTT T B MEINERS J C | 2005 | Analytical Chemistry2005，77，21： | 1 |
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