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| 1 | Non-alcoholic fatty liver disease and the metabolic syndrome:An update显示文摘Sedentary lifestyle and poor dietary choices are leading to a weight gain epidemic in westernized countries, subsequently increasing the risk for developing the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). NAFLD is estimated to affect approximate 30% of the general US population and is considered the hepatic manifestation of the metabolic syndrome. Recent findings linking the components of the metabolic syndrome with NAFLD and the progression to nonalcoholic steatohepatitis (NASH) will be reviewed; in particular, the role of visceral adipose tissue, insulin resistance, and adipocytokines in the exacerbation of these conditions. While no therapy has been proven effective for treating NAFLD/NASH, common recommendations will be discussed. | R Scott Rector John P Thyfault Yongzhong Wei Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 60 |
| 2 | Nonalcoholic fatty liver disease and mitochondrial dysfunction显示文摘Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD has recently dramatically increased and will continue to increase. NAFLD has also the potential to progress to hepatocellular carcinoma (HCC) or liver failure. NAFLD is strongly linked to caloric overconsumption, physical inactivity, insulin resistance and genetic factors. Although significant progress in understanding the pathogenesis of NAFLD has been achieved in years, the primary metabolic abnormalities leading to lipid accumulation within hepatocytes has remained poorly understood. Mitochondria are critical metabolic organelles serving as 'cellular power plants'. Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. This review is focused on the significant role of mitochondria in the development of NAFLD. | Yongzhong Wei R Scott Rector John P Thyfault Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 32 |
| 3 | Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length显示文摘AIM To analyze how various implants placement variables affect sacroiliac(SI) joint range of motion. METHODS An experimentally validated finite element model of the lumbar spine and pelvis was used to simulate a fusion of the SI joint using various placement configurations of triangular implants(iF use Implant System~?). Placement configurations were varied by changing implant orientation, superior implant length, and number of implants. The range of motion of the SI joint was calculated using a constant moment of 10 N-m with a follower load of 400 N. The changes in motion were compared between the treatment groups to assess how the different variables affected the overall motion of the SI joint. RESULTS Transarticular placement of 3 implants with superior implants that end in the middle of the sacrum resulted in the greatest reduction in range of motion(flexion/extension = 73%, lateral bending = 42%, axial rotation = 72%). The range of motions of the SI joints were reduced with use of transarticular orientation(9%-18%) when compared with an inline orientation. The use of a superior implant that ended mid-sacrum resulted in median reductions of(8%-14%) when compared with a superior implant that ended in the middle of the ala. Reducing the number of implants, resulted in increased SI joint range of motions for the 1 and 2 implant models of 29%-133% and 2%-39%, respectively,when compared with the 3 implant model.CONCLUSION Using a validated finite element model we demonstrated that placement of 3 implants across the SI joint using a transarticular orientation with superior implant reaching the sacral midline resulted in the most stable construct. Additional clinical studies may be required to confirm these results. | Derek P Lindsey Ali Kiapour Scott A Yerby Vijay K Goel | 2018 | World Journal of Orthopedics2018，9，3： | 3 |
| 4 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 5 | Freeoelectric memories 显示文摘 | SCOTT J F RAUJO C A P D | 1989 | Science1989，246，： | 2 |
| 6 | Species diversity enhance ecosystem functioning through inter- specific facilitation显示文摘 | BREDLEY J C MARGARET A P SCOTT L C | 2002 | Nature2002，24，： | 1 |
| 7 | Framework of Success Criteria for Design Build Projects 显示文摘 | A P C Chan D Scott E W M Lam | 2002 | Journal of Management in Engineering2002，18，3： | 1 |
| 8 | Ferroelectric memories显示文摘 | Scott J F Araugo C A P | 1989 | Science1989，246，： | 1 |
| 9 | New approaches to high speed civil transport multidisciplinary design and optimization 显示文摘 | ZINK P Scott DAN A DeLaurentis MARK A Hale | 2000 | IEEE2000，，： | 1 |
| 10 | Harmonic vibrational fre-quencies: An evaluation of Hartree-Fock,Meller-Plesset, quadratic configuration interaction, den-sity functional theory, and semiempirical scalefactors显示文摘 | Scott A P Radom L | 1996 | J Phys Chem1996，100，16： | 1 |
| 11 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 12 | Total knee arthroplasty with the PFC system results at a minimum of ten years and survivorship analysis 显示文摘 | Schai P A Thornhill T S Scott R D | 1998 | J Bone Joint Surg Br1998，80，5： | 1 |
| 13 | Vitellogenesis as a biomarker of reproductive disruption by xenobiotics显示文摘 | Nash J P Scott A P | 1999 | Aquaculture1999，177，： | 1 |
| 14 | PKI Elliptic Curve Cryptography,and Digital Signatures显示文摘 | William J C Edward P D Scott A R | 1999 | Computers and Security1999，18，： | 1 |
| 15 | Fossil charcoal: a plant fossil record preserved by fire 显示文摘 | Scott A C Jones T P | 1991 | Geol Today1991，7，： | 1 |
| 16 | Risk of cerebrovascular events after neck and supraclavicular radiotherapy:a systematic review显示文摘 | Scott A S Parr L A Johnstone P A | | 0，，02： | 1 |
| 17 | Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression显示文摘 | Scott S A Lakshimikuttysmmna A Sheridan D P | 2007 | Experimental hematology2007，35，2： | 1 |
| 18 | Field N2O, CO2 and CH4 fluxes in relation to tillage, compaction and soil quality in Scotland显示文摘 | Ball B C Scott A Parker J P | 1999 | Soil Tillage Res1999，53，： | 1 |
| 19 | An outbreak of multidrug-resistant Acinetobacter baumannii-caleoaeeticus complex infection in the US military health care system associated with military operations in Iraq显示文摘 | Scott P Deye G Srinivasan A | 2007 | Clin Infect Dis2007，44，12： | 1 |
| 20 | Sexually mature male goldfish release large quantities of androstenedione into the water where it functions as a pheromone 显示文摘 | Sorensen P W Pinillos M Scott A P | 2005 | Gen Comp Endocrinol2005，140，： | 1 |
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