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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Indian medicinal plants (Mexico) : Inhibitory activity on NF-kappa B as an anti-inflammatory model and antibacterial effects 显示文摘 | Bork P M Schmitz M L Weimann C | 1996 | Phytomedicine1996，3，3： | 1 |
| 3 | The interrelationship between surface froth characteristics and industrial flotation performance显示文摘 | MOOLMAN D W ALDRICH C SCHMITZ G P J | 1996 | Minerals Engineering1996，9，8： | 1 |
| 4 | Augmened vasoconstrictor response to serotonin precede development of artherosclerosis in aorta of WHHL rabbit显示文摘 | WINES P A SCHMITZ J M PFISTER S L | 1989 | Atheriosclerosis1989，9，2： | 1 |
| 5 | Factor mobility and international trade: the case of complementarity显示文摘 | Schmitz A Helmberger P | 1970 | The American Economic Review1970，，： | 1 |
| 6 | Postoperative pain management in orthopaedic patients: no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 7 | High-density optical mapping of the human somatosensory cortex to vibrotactile stimulation显示文摘 | Koch S P Menert J Schmitz C | 2009 | Neuroimage2009，47，1： | 1 |
| 8 | Contractual solutions to hold-up problems with quality uncertainty and unobservable investments显示文摘 | SCHMITZ P W | 2010 | Journal of Mathematical Economics2010，46，5： | 1 |
| 9 | Postoperative pain management in orthopaedic patients: No differences in pain score, but improved stress control by epidural anaesthesia显示文摘 | Adams HA Saatweber P Schmitz CS | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 10 | Cytokine removal and cardiovascular hemodynmics in septic patients with continuous venovenous hemofiltration显示文摘 | Heering P Morgera S Schmitz FJ | 1997 | Intensive Care Med1997，23，3： | 1 |
| 11 | Rho5p downregulates the yeast cell integrity pathway 显示文摘 | Schmitz H P Huppert S Lorberg A | 2002 | Journal of Cell Science2002，115，15： | 1 |
| 12 | The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B 显示文摘 | Schmitz M L Baeuerle P A | 1991 | EMBO J1991，10，12： | 1 |
| 13 | Class I integrons in gram-nagative isolates from different European hospitals and association with decreased susceptibility to multiple antibiotic compounds显示文摘 | Martinez-Freijo P Fluit A C Schmitz F J | 1998 | J Antimicrob Chemother1998，42，6： | 1 |
| 14 | The Role of c-FLIP in Modulation of CD95-induced Apoptosis 显示文摘 | Seaffidi C Schmitz I Krammer P H | 1999 | Biol Chem1999，274，： | 1 |
| 15 | Receptor-mediated regu-lation of the TRPM7 channel through its endogenous protein kinasedomain 显示文摘 | Takezawa R Schmitz C Demeuse P | 2004 | Proc Natl Acad Sci U S A2004，101，16： | 1 |
| 16 | Factor Mobilityand International Trade ; The Case of Complementarity显示文摘 | Schmitz A Helmberger P | 1970 | American Economic Review1970，60，： | 1 |
| 17 | Molecular investigation of the functional relevance of missense variants of ICAM- 1 显示文摘 | Vischer P Telgmann R Schmitz B | 2008 | Pharmacoge- netics and Genomics2008，18，11： | 1 |
| 18 | Postoperative pain management in orthopaedic patients:no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 19 | Influence of the nitriding and TiAlN/TiN coating thickness on the sliding wear behavior of duplex treated AISI H13 steel显示文摘 | TORRES R D SOARES P C SCHMITZ C | | 0，，05： | 1 |
| 20 | Heat production during different ultrasonic and conventional osteotomy preparations for dental implants显示文摘 | Rashad A Kaiser A Prochnow N Schmitz I Hoffmann E Maurer P | 2011 | Clin Oral Implants Res2011，22，12： | 1 |
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