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| 1 | Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors:A first-in-human case report and literature review显示文摘BACKGROUND Novel strategies are needed for improving guided bone regeneration(GBR) in oral surgery prior to implant placement, particularly in maxillary sinus augmentation(GBR-MSA) and in lateral alveolar ridge augmentation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autologous adipose-derived regenerative cells(UA-ADRCs), fraction 2 of plasma rich in growth factors(PRGF-2) and an osteoinductive scaffold(OIS)(UAADRC/PRGF-2/OIS) is superior to the combination of PRGF-2 and the same OIS alone(PRGF-2/OIS) in GBR-MSA/LRA.CASE SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridge augmentation. GBR-MSA/LRA was performed with UA-ADRC/PRGF-2/OIS on the right side, and with PRGF-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after GBRMSA/LRA. At the latter time point implants were placed. Radiographs(32 mo follow-up time) demonstrated excellent bone healing. No radiological or histological signs of inflammation were observed. Detailed histologic,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRGF-2/OIS resulted in better and faster bone regeneration than PRGF-2/OIS.CONCLUSION GBR-MSA with UA-ADRCs, PRGF-2, and an OIS shows effectiveness without adverse effects. | ?nder Solakoglu Werner G?tz Maren C Kiessling Christopher Alt Christoph Schmitz Eckhard U Alt | 2019 | World Journal of Stem Cells2019，11，2： | 3 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 4 | The interrelationship between surface froth characteristics and industrial flotation performance显示文摘 | MOOLMAN D W ALDRICH C SCHMITZ G P J | 1996 | Minerals Engineering1996，9，8： | 1 |
| 5 | The pattern of depressivesymptoms in people with type 2 diabetes : A prospective communitystudy 显示文摘 | Schmitz N Gariepy G Smith KJ | 2013 | J Psychosom Res2013，74，2： | 1 |
| 6 | Cross-talk tmfolded : MARCKS proteins显示文摘 | Arbuzova A Schmitz AA Vergeres G | 2002 | Biochem J2002，362，1： | 1 |
| 7 | Susceptibility oflodgepole pine to infestation by mountain pine beetles following partial cutting of stands显示文摘 | Amman G D McGregor M D Schmitz R F | 1988 | Can J For Res1988，18，： | 1 |
| 8 | An investigation of the dynamic absorber effect in high speed machining 显示文摘 | Duncan G S Tummond M F Schmitz T L | 2005 | International Journal of Machine Tools & Manufacture2005，45，45： | 1 |
| 9 | Cytokines removal and cardiovascular hemodynamies in septic patients with continuous hemofiltration显示文摘 | Heering R Morgera S Schmitz G ct al | 1997 | Intensive Care Med1997，23，3： | 1 |
| 10 | Expression and induction of anaphylatoxin C5a receptors in the rat liver显示文摘 | SCHLAF G SCHMITZ M ROTHERMEL E | 2003 | Histol Histopathol2003，18，1： | 1 |
| 11 | Are prothrombotic va- riants of platelet giycoprotein receptor polymorphisms in- volved in the pathogenesis of thrombotic microangiopathies 显示文摘 | Sucker C Schmitz M Hetzel G R | 2009 | Clin Appl Thromb Hemost2009，15，4： | 1 |
| 12 | Receptance coupling for dynamics prediction of assemblies with coincident neutral axes 显示文摘 | SCHMITZ T L DUNCAN G S | 2006 | Journal of Sound and Vibration2006，289，： | 1 |
| 13 | An inves- tigation of the dynamic absorber effect in high-speed machining显示文摘 | Duncan G S Tummond M F Schmitz T L | 2005 | International Journal of Machine Tools and Manufacture2005，45，45： | 1 |
| 14 | Analytical capillary isotachophoresis of human serum lipoproteins显示文摘 | Schmitz G Mollers C Richter V | 1997 | Electrophoresis1997，18，10： | 1 |
| 15 | An investigation of the dynamic absorber effect in high-speed machining显示文摘 | DUNCAN G S TUMMOND M F SCHMITZ T L | 2005 | International Journal of Machine Tools & Manufacture2005，45，45： | 1 |
| 16 | Genomic organization,promoter cloning,and chromosomal localization of the Dif-2 gene显示文摘 | Pietzsch A Buchler C Schmitz G | 1998 | Biochem Biophys Res Commun1998，245，3： | 1 |
| 17 | Effect of partial cutting treatments of lodgepole pine stands on the abundance and behavior of flying mountain pine beetles显示文摘 | Schmitz R F McGregor M D Amman G D | 1989 | Can J For Res1989，19，： | 1 |
| 18 | Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells显示文摘 | Liao H Langmann T Schmitz G | 2002 | Arterioscler Thromb Vasc Biol2002，22，1： | 1 |
| 19 | Role of ABCG1 and other ABCG family members in lipid metabolism显示文摘 | SCHMITZ G LANGMANN T HEIMERL S | 2001 | J Lipid Res2001，42，： | 1 |
| 20 | Gene expression profiling dur- ing spermatogenesis in early maturing male Atlantic salmon parr testes 显示文摘 | Maugars G Schmitz M | 2008 | General and Comparative Endo- crinology2008，159，23： | 1 |
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