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| 1 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 2 | Gapped BLAST and PSI-BLAST: a new generation of protein database searchprograms显示文摘 | Madden T L Schaffer A A Zhang J Zhang Z Miller W Lipman D J | 1997 | Nucle ic Acids Res1997，25，： | 1 |
| 3 | Correlations of receptor binding and metabolie and mltogenic potencies of insulin analogs designed for clinical use 显示文摘 | KURTZHALS P SCHAFFER L SORENSEN A | 2009 | Diabetes2009，49，： | 1 |
| 4 | Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use显示文摘 | KURTZHALS P SCHAFFER L SORENSEN A | 2000 | Diabetes2000，49，6： | 1 |
| 5 | Development of the as-cast microstructure in magnesium?aluminium alloys 显示文摘 | DAHLE K A LEE Z C NAVE M D SCHAFFER P L JOHNSON D H | 2001 | Light Metals2001，，1： | 1 |
| 6 | Taurine depletion, a novelmechanism for cardioprotection from regional ischemia 显示文摘 | Alio SN Bagby L Schaffer SW | 1997 | Am JPhysiol1997，273，42： | 1 |
| 7 | Gapped BLAST and PSI-BLAST: a new generation of protein database searchprograms显示文摘 | ALTSHCHUL S F MADDEN T L SCHAFFER A A | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 8 | Gapped BLAST and PSI-BLAST: A new generation of protein database search programs显示文摘 | Altschul S F Madden T L Schaffer A A | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 9 | Gapped BLAST and PSI-BLAST:A new generation of protein database search programs显示文摘 | Altschul S F Madden T L Schaffer A A | 1997 | Nucl Acids Res1997，25，： | 1 |
| 10 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | ALTSCHUL S F MADDEN T L SCHAFFER A A | 1997 | Nucl Acids Res1997，25，17： | 1 |
| 11 | Electrical signal measurements as a tool for monitoring responses of avocado (Persea americana Mill) trees to soil water content显示文摘 | Gil P Gurovich L Schaffer B | 2007 | Proceedings Ⅵ World Avocado Congress2007，26，2： | 1 |
| 12 | Impact of sexon uric acid levels and its relationship with the extentof coronary artery disease: A single-centre study 显示文摘 | Barbieri L Verdoia M Schaffer A | 2015 | Atherosclerosis2015，241，1： | 1 |
| 13 | Gapped BLAST and PSIBLAST:a new generation of protein database search programs显示文摘 | Altschul S F Madden T L Schaffer A A | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 14 | Gapped BLAST and PSI-BLAST: A new generation of protein database search programs显示文摘 | ALTSCHUL S F MADDEN T L SCHAFFER A A | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 15 | Gapped BLAST and PSI-BLAST:a new generation of protein database search program显示文摘 | Altschul S F Madden T L Schaffer A A | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 16 | Transient moisture gradi- ent in fire-exposed wood slab 显示文摘 | White R H Schaffer E L | 1981 | Wood and Fiber1981，13，1： | 1 |
| 17 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Altschul S F Madden T L Schaffer A A Zhang J Zhang Z Miller W Lipman D J | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 18 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | ALTSCHUL S F MADDEN T L SCHAFFER A A | 1997 | Nucleic Acids Research1997，25，17： | 1 |
| 19 | Molecular mechanistic origin of the toughness of natural adhesives,fibres and compo sites显示文摘 | Smith B L Schaffer T E Viani M | 1999 | Nature1999，399，6738： | 1 |
| 20 | The fruit cuticles of wild tomato species exhibit architectural and chemical diversity,providing a new model for studying the evolution of cuticle function显示文摘 | Yeats T H Buda G J Wang Z Chehanovsky N Moyle L C Jetter R Schaffer A A Rose J K C | | 0，，4： | 1 |
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