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| 1 | 腹部小切口阴道骶骨固定术治疗重度盆腔器官脱垂的临床分析显示文摘目的探讨腹部小切口阴道骶骨固定术(AMISC)治疗重度盆腔器官脱垂(POP)的适应证、手术技巧及临床效果。方法回顾性分析2016年6月至2019年10月在解放军总医院第四医学中心采用AMISC治疗、随访资料完整的重度POP患者共30例,包括穹隆脱垂10例、盆底重建手术后脱垂复发9例。AMISC特别适用于:(1)内科合并症多,不能耐受全身麻醉或腹腔镜手术,但能耐受蛛网膜下腔阻滞-硬膜外阻滞联合麻醉和经腹手术者;(2)需同时进行腹部其他手术的POP患者,如子宫肌瘤剔除术、子宫次全切除术等,利于手术标本的取出,避免碎解标本;(3)偏爱开腹手术或腹腔镜手术不够熟练的医师;(4)多次盆腹腔手术史,估计盆腔粘连较重的患者。通过盆腔器官脱垂定量(POP-Q)分度法评估客观效果,通过盆底不适调查表简表(PFDI-20)、盆底功能影响问卷简表(PFIQ-7)、患者整体印象改善评分(PGI-I)评估主观效果。结果所有患者均合并1~3种内科合并症,均顺利实施了AMISC,无中途停止、延长切口或改用其他术式者,手术时间为(110±19)min。术后随访时间为(33.5±12.4)个月(范围:8~49个月),术后POP-Q指示点Aa、Ba、C、Ap、Bp测量值均较术前明显下降(P<0.01),其中C点由术前的(2.33±2.50)cm明显降为(-7.54±1.18)cm。阴道顶端和后壁手术成功率均为100%(30/30),前壁为97%(29/30)。术后PFDI-20、PFIQ-7评分均显著下降(P<0.01),术后PGI-I问卷中29例患者为“明显改善”,总体主观满意率为97%(29/30)。术中骶前静脉丛出血2例(7%,2/30),无膀胱、肠管、输尿管等副损伤。术后无肠梗阻等严重并发症发生,阴道顶端网片暴露2例(7%,2/30)。结论AMISC既相对微创又规避了腹腔镜的不足,学习曲线短,是治疗重度POP有效、经济、便捷的手术路径。 | 沈文洁 鲁永鲜 刘昕 刘静霞 张迎辉 赵英 牛珂 王文英 王秋莹 Joseph Schaffer | 2021 | 中华妇产科杂志2021，56，5： | 8 |
| 2 | Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report显示文摘Hepatocellular carcinoma (HCC) recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemo- embolization (TACE), radiofrequency ablation (RFA), ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres (SIR-Spheres, Sirtex Medica Inc., Lake Forest, IL, USA). Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein (AFP) level. There were no adverse consequences of initial treatment. | Louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh Randolph L Schaffer | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 3 | Methods to Simulate Airborne Sound Transmission at Railway Door Panels with Deterministic Wave Theoretical Approaches显示文摘 | Helmut Schaffer Ernst Pucher | 2013 | 材料科学与工程(中英文A版)2013，3，11： | 2 |
| 4 | Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study显示文摘 | Alon Schaffer Monica Verdoia Ettore Cassetti Paolo Marino Harry Suryapranata Giuseppe De Luca | 2014 | Thrombosis Research2014，，： | 2 |
| 5 | Covered nitinol stents for the treatment of esophageal strictures and leaks显示文摘AIM:To compare 2 different types of covered esophageal nitinol stents(Ultraflex and Choostent) in terms of efficacy,complications,and long-term outcome.METHODS:A retrospective review of a consecutive series of 65 patients who underwent endoscopic placement of an Ultraflex stent(n = 33) or a Choostent(n = 32) from June 2001 to October 2009 was conducted.RESULTS:Stent placement was successful in all patients without hospital mortality.No significant differences in patient discomfort and complications were observed between the Ultraflex stent and Choostent groups.The median follow-up time was 6 mo(interquartile range 3-16 mo).Endoscopic reintervention was required in 9 patients(14%) because of stent migration or food obstruction.No significant difference in the rate of reintervention between the 2 groups was observed(P = 0.8).The mean dysphagia score 1 mo after stent placement was 1.9 ± 0.3 for the Ultraflex stent and 2.1 ± 0.4 for the Choostent(P = 0.6).At 1-mo follow-up endoscopy,the cover membrane of the stent appeared to be damaged more frequently in the Choostent group(P = 0.34).Removal of the Choostent was possible up to 8 wk without difficulty.CONCLUSION:Ultraflex and Choostent proved to be equally reliable for palliation of dysphagia and leaks.Removal of the Choostent was easy and safe under mild sedation. | Davide Bona Letizia Laface Luigi Bonavina Emmanuele Abate Moshe Schaffer Ippazio Ugenti Stefano Siboni Rosaria Carrinola | 2010 | World Journal of Gastroenterology2010，16，18： | 2 |
| 6 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 7 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs显示文摘 | Altschul S Madden T Schaffer A | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 8 | Gapped BLAST and PSI-BLAST: a new generation of protein database searchprograms显示文摘 | Madden T L Schaffer A A Zhang J Zhang Z Miller W Lipman D J | 1997 | Nucle ic Acids Res1997，25，： | 1 |
| 9 | Microbial degradation of nonylphenol and other alkylphenols-our evolving view显示文摘 | CORVINI P F SCHAFFER A SCHLOSSER D | 2006 | Appl Applied Microbiology and Biotechnology2006，72，： | 1 |
| 10 | Correlations of receptor binding and metabolie and mltogenic potencies of insulin analogs designed for clinical use 显示文摘 | KURTZHALS P SCHAFFER L SORENSEN A | 2009 | Diabetes2009，49，： | 1 |
| 11 | Relationship of Ki-ms mutations in colon cancers to tumor location, stage, and survival : a population - based study 显示文摘 | Samowitz WS Curtin K Schaffer D | 2000 | Cancer Epide- miol Biomarkers Prey2000，9，： | 1 |
| 12 | Myocardial ischemic-reperfusion in-jury in a rat model of metabolic syndrome显示文摘 | Mozaffari MS Schaffer SW | 2008 | Obesity(SilverSpring)2008，16，10： | 1 |
| 13 | Cancer stem cells: how can we target them显示文摘 | Ischenko I Seeliger H Schaffer M | 2008 | Curt Med Chem2008，15，： | 1 |
| 14 | The use of thyroglobulin monclonal antibodies against thyroglobulin in immunoperoxidase techniques显示文摘 | Ormanns W Schaffer R | 1983 | Histochemistry1983，78，2： | 1 |
| 15 | Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use显示文摘 | KURTZHALS P SCHAFFER L SORENSEN A | 2000 | Diabetes2000，49，6： | 1 |
| 16 | Development of the as-cast microstructure in magnesium?aluminium alloys 显示文摘 | DAHLE K A LEE Z C NAVE M D SCHAFFER P L JOHNSON D H | 2001 | Light Metals2001，，1： | 1 |
| 17 | Liquid phase sintering of aluminium alloys显示文摘 | SCHAFFER G B SERCOMBE T B LUMLEY R N | 2001 | Materials Chemistry and Physics2001，67，： | 1 |
| 18 | Taurine depletion, a novelmechanism for cardioprotection from regional ischemia 显示文摘 | Alio SN Bagby L Schaffer SW | 1997 | Am JPhysiol1997，273，42： | 1 |
| 19 | T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct显示文摘 | Aigner M Feulner J Schaffer S | 2013 | Leukemia2013，27，5： | 1 |
| 20 | The Role of work Group Status as a Contextual Variable in Relational Demography Research显示文摘 | Schaffer B S Riordan C M | 2011 | Jour- nal of Business Diversity2011，11，1： | 1 |
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