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| 1 | Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor显示文摘Neuroendocrine tumors(NET) are a heterogeneous group of cancers, with indolent behavior. The most common primary origin is the gastro-intestinal tract but can also appear in the lungs, kidneys, adrenals, ovaries and other organs. In general, NET is usually discovered in the metastatic phase(40%-80%). The liver is the most common organ involved when metastases occur(40%-93%), followed by bone(12%-20%) and lung(8%-10%).A number of different therapeutic options are available for the treatment of hepatic metastases including surgical resection, transplantation, ablation, trans-arterial chemoembolization, chemotherapy and somatostatin analogues. Recently, molecular targeted therapies have been used, usually in combination with other treatment options, to improve outcomes in patients with metastases. This article emphasizes on the role of surgery in the treatment of liver metastases from NET. | Sayee Sundar Alagusundaramoorthy Roberto Gedaly | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 2 | H pylori seroprevalence in patients with lung cancer显示文摘AIM: To assess H pylori seroprevalence in lung cancer and determine whether there is a potential association between lung cancer and H pylori infection. METHODS: The study was conducted on forty consecutive patients with lung cancer, confirmed by pathology (32 men, 8 women; mean age 55.50 ± 11.91 years, range 16-77 years). Forty healthy subjects (25 men, 15 women; mean age 43.08 ± 12.60 years, range 20-79 years) from the patients’ family members were matched to each case subject on the basis of age and socioeconomic status. H pylori infection was detected with a commercially available immunoglobulin G (IgG) enzyme-linked immunosorbent assay (Trinity kit, Biotech co., USA), previously validated in adults (86% sensitivity, 96% specificity) against a gold standard of culture and histology. RESULTS: H pylori seropositivity was present in 52.5% of patients with lung cancer in comparison to 45.0% of healthy control subjects. Although H pylori seropositivity was more frequent in lung cancer patients than in controls, the difference did not reach statistical significance (OR = 1.35, 95% CI = 0.56-3.25; P = 0.65). In addition, there was no significant difference between cases and controls in terms of gastrointestinal symptoms. CONCLUSION: The earlier described association between H pylori infection and lung cancer was not supported in this study. Further studies with larger sample sizes should be undertaken to assess the frequency of H pylori infection in patients with lung cancer and their potential association. | Katayoon Najafizadeh Sayeed Falah Tafti Masoud Shiehmorteza Masoud Saloor Masoud Jamali | 2007 | World Journal of Gastroenterology2007，13，16： | 6 |
| 3 | High-pressure adsorption of gases on shales: Measurements and modeling显示文摘 | Pongtorn Chareonsuppanimit Sayeed A. Mohammad Robert L. Robinson Khaled A.M. Gasem | 2012 | International Journal of Coal Geology2012，，： | 4 |
| 4 | Nigella sativa protects against isoproterenol-induced myocardial infarction by alleviating oxidative stress,biochemical alterations and histological damage显示文摘Objective: To evaluate the cardioprotective effect of Nigella sativa L.(N.sativa) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of N.sativa(EENS)and N.sativa oil alone and along with enalapril for 28 days.MI was induced by subcutaneous administration of isoproterenol(85 mg/kg) in two consecutive doses.Levels of cardiac biomarkers and antioxidant enzymes such as creatine kinase–N-acetyl-L-cysteine, lactate dehydrogenase, aspartate aminotransferase, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were evaluated along with gross histopathological examination.Results: Isoproterenol(85 mg/kg) induced MI by causing the significant(P < 0.01)reduction in the activity of cardiac biomarkers(creatine kinase–N-acetyl-L-cysteine,lactate dehydrogenase, aspartate aminotransferase) and antioxidant markers(superoxide dismutase, catalase, glutathione) along with significant(P < 0.01) increase in the level of malondialdehyde.Furthermore, histopathological evaluation also confirmed the isoproterenol-induced MI.Pretreatment with EENS(800 mg/kg) and combination of EENS(800 mg/kg) with enalapril(1 mg/kg) significantly(P < 0.01) prevented the development of these alteration and restored activity of cardiac biomarkers as well as antioxidant markers almost near to normal levels.Histopathological evaluation of cardiac tissue further confirmed the restoration of biochemical activity.Conclusions: Experimental findings thus indicate that EENS(800 mg/kg) demonstrated cardioprotective effect against isoproterenol-induced MI by restoring cardiac biomarkers and antioxidant status. | Md.Quamrul Hassan Mohd.Akhtar Sayeed Ahmed Aftab Ahmad Abul Kalam Najmi | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，4： | 4 |
| 5 | Endoscopic treatment modalities and outcomes in nonvariceal upper gastrointestinal bleeding显示文摘BACKGROUND In nonvariceal upper gastrointestinal bleeding(NVUGIB),the optimal volume of adrenaline,the optimal number of hemoclips,and the application of thermal coagulation in determining patient outcomes have not been well studied.AIM To demonstrate a dose-response relationship between the commonly used endoscopic modalities for the treatment of non-variceal upper gastrointestinal bleeding and various clinical outcomes.METHODS Patients presenting with NVUGIB were retrospectively identified and analyzed.These patients were stratified as follows:(1)>10 mL of adrenaline injected vs≤10 mL;(2)>1 hemoclip placed vs≤1 hemoclip;(3)Heater probe used or not;and(4)>2 treatment modalities used vs≤2.The primary outcomes were rebleeding and the need for repeat endoscopy.The secondary outcomes were the need for surgery,required transfusions,length of hospital stay,death during the same admission period and 30 d mortality.Patients with NVUGIB who required endoscopic therapy were included.Those who did not require endoscopic therapy or were initially treated with surgery or embolization were excluded.RESULTS In all,501 patients with NVUGIB were treated.One hundred sixty-one(32.1%)patients needed endoscopic therapy.The injection of<10 mL of adrenaline was associated with less rebleeding(P<0.0001),the need for repeat endoscopy(P=0.001)and a decreased length of hospital stay(P=0.026).The use of>2 treatment modalities were associated with increased rebleeding(P=0.009)and the need for repeat endoscopy(P=0.048).The placement of>1 hemoclip was associated with a decreased length of hospital stay(P=0.044).The rates of surgery and death were low,and there were no other significant differences between the patient groups.CONCLUSION The more restrictive use of adrenaline and number of endoscopic modalities to treat NVUGIB with the more liberal use of hemoclips was associated with better patient outcomes. | Benjamin Cherng Hann Yip Hossain Sayeed Sajjad Jie-Xun Wang Constantinos P Anastassiades | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，2： | 2 |
| 6 | 新型N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺胺类药物作为潜在抗疟疾、抗真菌和抗细菌药物的合理药物设计、合成和生物学评价显示文摘目的磺胺、磺胺嘧啶和氨苯砜是第一批通过破坏叶酸生物合成过程来治疗疟疾的磺胺类药物,叶酸生物合成过程是寄生虫存活的关键。因此,我们旨在通过合理的药物设计方法合成新型N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺衍生物。方法按常规方法合成所有化合物,并用光谱分析(1H核磁共振和质谱)对产物进行表征。使用薄层色谱法(TLC)监测反应进程。分析了所有衍生物在疟原虫半胱氨酸蛋白酶falcipain-2变构位点的有效结合模式。采用肉汤稀释法测定抗菌和抗真菌活性。结果S6(N-(2-噻唑-4-基)-乙酰基-氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺与S9(N-(1H-苯并[d]咪唑-2-基)氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺形成5个氢键;S8(N-(2-1H-咪唑-2-基)氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺和S10(N-(1-苯并[d]咪唑-5-基)氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺与酶的变构位点形成四个氢键。考虑到与目标酶的对接分数和氢键的形成,新的衍生物被加工用于湿实验室合成。所有新合成的衍生物都具有体外抗疟疾、抗真菌和抗菌活性。与标准品相比,所有衍生物对恶性疟原虫株表现出足够的敏感性。此外,化合物S9和S10显示出最有效的双重抗微生物和抗疟疾活性。它们在分子对接研究中也显示出强大的分子相互作用。结论基于以上结果,我们认为N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺衍生物具有作为抗疟药、抗真菌药和抗菌剂的优异生物潜力。 | Ahmed Hassen Shntaif Sharuk Khan Ganesh Tapadiya Anand Chettupalli Shweta Saboo Mohd Sayeed Shaikh Falak Siddiqui Ramkoteswra Rao Amara | 2021 | Digital Chinese Medicine2021，4，4： | 2 |
| 7 | Lipid Lowering for Secondary Prevention of Cardiovascular Disease in Older Adults显示文摘 | Joseph E. Thomas Andrew M. Tershakovec Charlotte Jones-Burton Reza A. Sayeed JoAnne M. Foody | 2010 | Drugs & Aging2010，，12： | 1 |
| 8 | Maximizing survival potential in very high risk cardiac surgery显示文摘 | Westaby S Balacumaraswami L Sayeed R | | 0，，： | 1 |
| 9 | PI- Fuzzy estimations for Tuning the Stator Resistance in DTC显示文摘 | Sayeed Mir Malik E Elbuluk Donald S Zinger | 1998 | IEEE trans on PE1998，13，2： | 1 |
| 10 | PI-Fuzzy Estimations Tuning the Stator Resistance in DTC显示文摘 | Sayeed Mir Malik E Elbuluk Donald S Zinger | 1998 | IEEE Trans on Power Electrics1998，13，2： | 1 |
| 11 | Machining Fixture Design and Analysis Software显示文摘 | Sayeed Q A | 1994 | InterJ of Production Research1994，32，7： | 1 |
| 12 | Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women 显示文摘 | GOODSON W H LUCIANI M G SAYEED S A | 2011 | Carcinogenesis2011，32，11： | 1 |
| 13 | Prognostic factors in resected satellite-nodule T4 non-small cell lung cancer显示文摘 | Rao J Sayeed RA Tomaszek S | 2007 | Ann Thorac Surg2007，84，3： | 1 |
| 14 | Inhibition of human brain tumor cell growth by a receptor-operated calcium channel blocker显示文摘 | Sayeed MM Wurster RD | 1993 | Cancer Lett1993，72，： | 1 |
| 15 | Arthroscopic treatment of localized pigmented villonodular synovitis:long-term functional results显示文摘 | Rhee PC Sassoon AA Sayeed SA | 2010 | Am J Orthop (Belle Mead NJ)2010，39，9： | 1 |
| 16 | Diabetes and impaired fasting glycemia in a rural population of Bangladesh显示文摘 | Sayeed M A Mahtab H Akter Khanam P | 2003 | Diabetes Care2003，26，4： | 1 |
| 17 | Direct inhibition of the mitochondrial permeability transition pore : a possible mech- anism responsible for anti - apoptotic effects of melatonin 显示文摘 | ANDRABI S A SAYEED I SIEMEN D | 2004 | FASEB J2004，18，7： | 1 |
| 18 | Clostridium perfringens toxin genotypes in the feces of healthy North American 显示文摘 | Carman R J Sayeed S Li J | 2008 | Anaerobe2008，14，2： | 1 |
| 19 | Special issue on self-organizing distributed collaborative sensor networks 显示文摘 | A Sayeed D Estrin G Pottie K Ramchandran | 2005 | IEEE Journal of Selected Areas on Communication2005，23，4： | 1 |
| 20 | Clostridium perfringens tox- in genotypes in the feces of healthy North American 显示文摘 | Carman R J Sayeed S Li J | 2008 | An- aerobe2008，14，2： | 1 |
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