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| 1 | siRNA therapeutics:a clinical reality显示文摘Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)therapeutics.Despite its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of siRNA.Twenty years after the discovery of RNAi,siRNA therapeutics finally charts its way into clinics.As we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease treatments.Herein,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical trials.Lastly,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics. | Phei Er Saw Er-Wei Song | 2020 | Science China(Life Sciences)2020，63，4： | 26 |
| 2 | Non-coding RNAs:the new central dogma of cancer biology显示文摘The central dogma of molecular biology states that the functions of RNA revolve around protein translation.Until the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed RNAs.Recent discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being'junk'transcriptional products to'yet to be elucidated'—and potentially monumentally important—RNAs.Most ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and fates.In major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ncRNAs.Herein,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics. | Phei Er Saw Xiaoding Xu Jianing Chen Er-Wei Song | 2021 | Science China(Life Sciences)2021，64，1： | 21 |
| 3 | Methane hydrate formation and dissociation in synthetic seawater显示文摘The formation and dissociation of methane gas hydrate at an interface between synthetic seawater (SSW) and methane gas have been experimentally investigated in the present work. The amount of gas consumed during hydrate formation has been calculated using the real gas equation. Induction time for the formation of hydrate is found to depend on the degree of subcooling. All the experiments were conducted in quiescent system with initial cell pressure of 11.14 MPa. Salinity effects on the onset pressure and temperature of hydrate formation are also observed. The dissociation enthalpies of methane hydrate in synthetic seawater were determined by Clausius-Clapeyron equation based on the measured phase equilibrium data. The dissociation data have been analyzed by existing models and compared with the reported data. | Vikash Kumar Saw Iqbal Ahmad Ajay Mandal G.Udayabhanu Sukumar Laik | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 12 |
| 4 | Phage display screening of therapeutic peptide for cancer targeting and therapy显示文摘Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018.Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and selectivity.In this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening methods.We will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display screening.We will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics. | Phei Er Saw Er-Wei Song | 2019 | Protein & Cell2019，10，11： | 11 |
| 5 | 纳米晶铁钴基软磁材料的研究显示文摘铁钴基纳米晶软磁性材料具有高居里温度的非晶纳米晶两相结构,通过两相结构的匹配完成纳米晶粒间的磁矩交换耦合,使得材料在高温环境下具备优异的软磁性能。通过采用 VSM、TEM、XRD 等技术对材料软磁性能、组织结构以及软磁性能的热稳定性的研究与分析,优化了 FeCoHfBCu 合金成分。试验表明(Fe0.6Co0.4)86Hf7B6Cu1合金在500~600 ℃的工作温度区间范围内具备最佳的饱和磁化强度和较低矫顽力,并且 550 ℃条件下具有优异的软磁性能热稳定性。该材料是高温软磁应用领域的重要候选材料。 | Tadeusz Kulik(波) 梁秀兵 Jaro■saw Ferenc(波) 徐滨士 | 2004 | 中国表面工程2004，17，5： | 10 |
| 6 | 新加坡人口结构的变化显示文摘本章将从族群、性别构成、年龄结构、宗教构成和公民类型等方面来探讨新加坡的人口结构。在过去几十年里,新加坡人口结构的变化不仅与诸如移民、死亡率和出生率等人口学方面的因素有关,而且也与社会及经济发展变化密切相关。这些变化因素对新加坡人口结构的各个方面产生了不同方式和不同程度的影响。例如,我们在下一章将要讨论的国际移民问题,就对新加坡人口结构的许多方面产生了广泛而深刻的影响。 | 苏瑞福(Saw Swee—Hock) 王艳(译) 谧谷(校) | 2008 | 南洋资料译丛2008，，4： | 8 |
| 7 | 含纳米CeO_2,Cu混合物添加剂润滑油摩擦学性能研究显示文摘本文中将纳米二氧化铈与铜粒子混合物应用于润滑油添加剂,使润滑油具有优良的减摩、抗磨性能。纳米二氧化铈与铜粒子用适当的表面活性剂进行表面改性处理,经表面改性的纳米粒子在润滑油中具有良好的分散、稳定性。采用透射电镜(TEM)观察与测量纳米二氧化铈、铜粒子的形貌和平均直径。应用四球摩擦磨损试验机测定添加纳米二氧化铈、铜粒子的润滑油的极压性能(P_B)、磨痕直径(WSD)和摩擦因数(μ)等。研究结果表明,最佳的纳米二氧化铈、铜粒子的总添加量为0.6%左右、纳米二氧化铈、铜粒子的质量分数之比为1:1,该润滑油具有最佳的的减摩、抗磨作用。文中还探讨了纳米二氧化铈、铜粒子混合物具有优良摩擦学性能的机理。 | 顾卓明 顾彩香 Saw Thandar Shwe | 2007 | 材料热处理学报2007，28，B08： | 7 |
| 8 | Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment显示文摘Chimeric antigen receptor(CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specificity of tumor antigens and independent cytotoxicity from major histocompatibility complex molecules through a monoclonal antibody in addition to the Tcell receptor. CAR-T cell has proven its effectiveness, primarily in hematological malignancies, specifically where the CD19 CAR-T cells were used to treat B-cell acute lymphoblastic leukemia and B-cell lymphomas. Nevertheless, there is little progress in the treatment of solid tumors despite the fact that many CAR agents have been created to target tumor antigens such as CEA,EGFR/EGFRvIII, GD2, HER2, MSLN, MUC1, and other antigens. The main obstruction against the progress of research in solid tumors is the tumor microenvironment, in which several elements, such as poor locating ability, immunosuppressive cells,cytokines, chemokines, immunosuppressive checkpoints, inhibitory metabolic factors, tumor antigen loss, and antigen heterogeneity, could affect the potency of CAR-T cells. To overcome these hurdles, researchers have reconstructed the CAR-T cells in various ways. The purpose of this review is to summarize the current research in this field, analyze the mechanisms of the major barriers mentioned above, outline the main solutions, and discuss the outlook of this novel immunotherapeutic modality. | Zijun Zhao Xiaoyun Xiao Phei Er Saw Wei Wu Hongyan Huang Jiewen Chen Yan Nie | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 9 | p38MAPK抑制剂增强阿霉素抑制乳腺癌细胞增殖的体外研究显示文摘以乳腺癌细胞株MCF-7为研究对象,经阿霉素及阿霉素联合p38MAPK抑制剂(SB20580)作用细胞,通过MTT法测定细胞存活率、光学显微镜观察细胞形态变化。实验数据显示相同药物浓度下,SB20580可以明显降低MCF-7细胞存活率。结果表明p38MAPK抑制剂可以促进阿霉素抑制细胞增殖的效果。 | 蒋宇翔 陈栋 王玮 李贵发 Fuqua SAW 崔玉昆 赵辅昆 | 2010 | 浙江理工大学学报(自然科学版)2010，27，1： | 6 |
| 10 | Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics显示文摘Bispecific antibodies(bsAbs)refer to a large family of molecules that recognize two different epitopes or antigens.Although a series of challenges,especially immunogenicity and chain mispairing issues,once hindered the development of bsAbs,they have been gradually overcome with the help of rapidly developing technologies in the past 5 decades.In the meantime,an increasing number of bsAb platforms have been designed to satisfy different clinical demands.Currently,numerous preclinical and clinical trials are underway,portraying a promising future for bsAb-based cancer treatment.Nevertheless,bsAb drugs still face enormous challenges in their application as cancer therapeutics,including tumor heterogeneity and mutational burden,intractable tumor microenvironment(TME),insufficient costimulatory signals to activate T cells,the necessity for continuous injection,fatal systemic side effects,and off-target toxicities to adjacent normal cells.Therefore,we provide several strategies as solutions to these issues,which comprise generating multispecific bsAbs,discovering neoantigens,combining bsAbs with other anticancer therapies,exploiting natural killer(NK)-cell-based bsAbs and producing bsAbs in situ.In this review,we mainly discuss previous and current challenges in bsAb development and underscore corresponding strategies,with a brief introduction of several typical bsAb formats. | Heliang Li Phei Er Saw Erwei Song | 2020 | Cellular & Molecular Immunology2020，17，5： | 6 |
| 11 | 东南亚地区五加科植物进化关系的初步研究(英文)显示文摘东南亚五加科包含14个属约500种,本文应用ITS片段对该区五加科植物的进化关系作了初步研究。研究显示该地区五加科植物具有复杂的起源,很多属属于亚洲掌状复叶类群或Hedereae族的一支中。该区特有类群Harmsiopanax形态上非常特殊,但其系统位置尚未不明朗。在Brassaiopsis属中,有几种形态差异较大的种,但它们属同一单系,加之各种间ITS序列差异较小,故应是新近起源于马来亚半岛和苏门达腊岛的种类。Wardenia simplex聚类在Brassaiopsis一支中,故不支持将Wardenia作为独立的属。东南亚地区对于Schefflera属的发育非常重要,已有的证据显示该区的Schefflera属植物属于该属的Heptapleurum类群。马来亚与泰国南部的Dendropanax lancifolius并没有与Dendropanax属的核心类群聚在一起,其系统地位需进一步研究。Macropanax maingayi是非常特殊的一个种,曾被独立分出,成立了单种属Hederopsis。本文的分析清楚表明它属于Macropanax属。Aralia merrillii因为其不同寻常的攀缘特性而被独立出来,建立了单种属Acanthophora,但ITS序列分析支持将它置于Aralia属中。新增的取样继续支持Arthrophyllum的单系性。Os-moxylon的原初分布范围在东南亚,它是五加科系统进化树上孤立的类群。 | 文军 朱昱苹 Chunghee LEE Elizabeth WIDJAJA LENG Guan Saw | 2008 | 云南植物研究2008，30，4： | 5 |
| 12 | Low mtDNA diversity among widespread Australian diamondback moth Plutella xylostella (L,) suggests isolation and a founder effect显示文摘澳大利亚的有菱形斑纹的蛾(DBM ) 的人口 Plutella xylostella (L.) ,饰有十字架的庄稼的一个严肃的害虫,极其越过澳大利亚显示基因区别的底层,新西兰取样地点,用微卫星标记以前决定了。这些数据建议与澳大利亚的 DBMbeing 一致的当代的基因怜的高水平漫游的种。这里,我们用 CO1 基因的 257 bp 碎片的 themitochondrial 脱氧核糖核酸序列为单倍体型变化检验澳大利亚的 DBM 样品。我们从新西兰,肯尼亚和朝鲜在样品把这个变化比作相等的 mtDNA 顺序变化。用在整个澳大利亚收集的 42 蛾,我们证明澳大利亚的 DBM 有两低 mtDNA 单倍体型和核苷酸差异。检测的三澳大利亚的 haplotypes 仔细从印度尼西亚与普通单倍体型组一起被联系,他们聚类。另外,澳大利亚的 haplotypefrequency 分发更从肯尼亚或朝鲜比那从印度尼西亚类似于那。这些数据与原来的强壮的澳大利亚 / 新的 Zealand 创始人效果一致,从 south-easternAsian 来源,与随后的继续的隔离。在一个单个季节, PXMtOl 的频率,最普通的澳大利亚的单倍体型,用一个聚合酶链反应 BiPASA 方法越过南部的澳大利亚和新西兰在 15 地点传播被估计。PXMtOl 单倍体型频率变化是异质的,建议是 notdetectedusing 的人口隔离的小度微卫星。区别不是地理距离的功能。这些数据由成立女性的小数字建议短暂、分散的本地殖民地化事件。 | JESSLYN SAW NANCY M. ENDERSBY STEPHEN W. MCKECHNIE | 2006 | Insect Science2006，13，5： | 3 |
| 13 | Myopia显示文摘 | Ian G Morgan Kyoko Ohno-Matsui Seang-Mei Saw | 2012 | The Lancet2012，，9827： | 2 |
| 14 | Myopia显示文摘 | Ian G Morgan Kyoko Ohno-Matsui Seang-Mei Saw | 2012 | The Lancet2012，，9827： | 2 |
| 15 | Hyperhomocyst(e)inemia and Risk of Ischemic Stroke Among Young Asian Adults显示文摘 | Nigel Choon-Kiat Tan N. Venketasubramanian Seang-Mei Saw Helen Tjoei-Lian Tjia | 2002 | Stroke: Journal of the American Heart Association2002，，8： | 2 |
| 16 | Hyperhomocysteinemia and risk of isehemie stroke omong young Asian adults显示文摘 | Tan NC Venketasubramanian N Saw SM | 2002 | Stroke2002，33，： | 1 |
| 17 | Evidence-based analysis of surgical interventions for uncomplicated rhegmatogenous retinal detachment显示文摘 | Saw S N Gazzard G Wagle A M | 2006 | Acta Ophthahnol Scand2006，84，5： | 1 |
| 18 | Diamond-like amorphous carbon thin films by dc magnetron sputtering显示文摘 | Saw K G Idrus RM Ibrahim K | 2000 | Journal of Materials Science Letters2000，19，9： | 1 |
| 19 | Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke 显示文摘 | Sawe N Steinberg G Zhao H | 2008 | J Neurosci Res2008，86，8： | 1 |
| 20 | The age of menopause and themenopause transition in a multiracial population: a nation-wideSingapore study显示文摘 | Loh F H Khin L W Saw S M | 2005 | Maturitas2005，52，3： | 1 |
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