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| 1 | B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors显示文摘The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related studies and suggest that the B7-H3 molecule could be a promising prognostic biomarker and therapeutic target for anticancer immunotherapy in these tumors. | Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 2 |
| 2 | Contribution to the biophysics of lethal effects of electric field on microorganisms显示文摘 | Savic P Johnson B F | 1996 | Biochimica et Biophysica Acta1996，1278，1： | 1 |
| 3 | GAnet:genetic algorithm platform for pipe network optimization显示文摘 | Morley M S Atkinson R M Savic D A | 2001 | Advances in Engineering Software2001，，32： | 1 |
| 4 | Ganet Genetic Algorithm Platform for Pipe Network Optimization显示文摘 | Atkinson R M Savic D A | 2001 | Advances in Engineering Software2001，32，6： | 1 |
| 5 | Experimental study of non-linear effects in hydraulic fracture propagation显示文摘 | De Pater C J Weyers L Savic M etal | 1993 | SPE1993，，25： | 1 |
| 6 | A variable rate coefficient chlorine decay model 显示文摘 | Jonkergouw P M R Khu S T Savic D A | 2009 | Environ Sci Technol2009，43，2： | 1 |
| 7 | Sex-related analysis of shortand long-term clinical outcomes and bleeding among patients treated with primary percutaneous coronary intervention:an evaluation of the RISK-PCI data显示文摘 | Mrdovic I Savic L Asanin M | 2013 | Can J Cardiol2013，29，9： | 1 |
| 8 | Targeting polyketide synthase gene pool within actinomycetes: new degenerate primers显示文摘 | Savic M Vasiljevic B | 2006 | Journal ofIndustrial Microbiology and Biotechnology2006，33，6： | 1 |
| 9 | The NLRP3 inflammasome, a target for therapy in diverse disease states 显示文摘 | Cook GP Savic S Wittmann M | 2010 | EurJ Immunol2010，40，3： | 1 |
| 10 | An alkyl polyglucoside- mixed emulsifier as stabilizer of emulsion systems: the influence of colloidal structure on emulsions skin hydration potential 显示文摘 | Savic S Lukic M Jaksic 1 | 2011 | J ColloMInterJktce Sci2011，358，1： | 1 |
| 11 | p H control and the production of extracellular dextransucrase by Leuconostoc mesenteroides显示文摘 | LAZIC M VELJKOVIC V SAVIC D | 1991 | World Journal of Microbiology and Biotechnology1991，7，1： | 1 |
| 12 | Dam-break flood waves computed by modified Godunov method显示文摘 | Savic L J Holly F M | 1993 | J Hydr Res1993，31，2： | 1 |
| 13 | Lactobionic acid in a natural alkylpolyglucoside-based vehicle:assessing safety and efficacy aspects in comparison to glycolic acid显示文摘 | Tasic-Kostov M Savic S Lukic M | | 0，，09： | 1 |
| 14 | Autoinflammatory syndromes and cellular responses to stress : pathophysiology, diagnosis and new treatment perspectives 显示文摘 | Savic S Dickie LJ Wittmann M | 2012 | Best Pract Res Clin Rheumatol2012，26，4： | 1 |
| 15 | Radial nerve repair using an autologous denatured muscle graft: comparison with outcomes of nerve graft repair 显示文摘 | Roganovic Z Ilic S Savic M | 2007 | Acta Neurochir (Wien)2007，149，10： | 1 |
| 16 | Determination of the target nucleosides for members of two families of 16SrRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics显示文摘 | Savic M Lovric J Tomic TI | 2009 | Nucleic Acids Res2009，37，16： | 1 |
| 17 | TRIP12and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes显示文摘 | GUDJONSSON T ALTMEYER M SAVIC V | 2012 | Cell2012，150，4： | 1 |
| 18 | The need for implementation of International Commission on Trichinellosis recommendations,quality assurance standards,and proficiency sample programs in meat inspection for trichinellosis in Serbia显示文摘 | Djordjevic M Cuperlovic K Savic M | 2005 | Vet Parasitol2005，132，12： | 1 |
| 19 | Bidirectional effects of benzodiazepine binding site ligands on passive avoidance acquisition and retention:differential antagonism by flumazenil and beta-CCt显示文摘 | Savic M M Obradovic D I Ugresic N D | 2005 | Psychopharmacology(Berl)2005，180，3： | 1 |
| 20 | Electrophysiological characterization of 'giant' cells in stratum radiatum of the CA3 hippocampal region显示文摘 | SAVIC N SCIANCALEPORE M | 2001 | J Neurophysiol2001，85，5： | 1 |
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