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| 1 | 红树植物内生真菌Penicillium sp.的化学成分显示文摘应用各种层析手段,从红树植物内生真菌GT26158菌丝体的甲醇提取物中分离纯化了7个含氮化合物,结合多种波谱方法(ESI-MS,1D-NMR,2D-NMR),它们被鉴定为2′-deoxyuridine(1)、thymidine(2)、2′-deoxyad-enosine(3)、cyclo(tyrosyl-phenylalanyl,4)、serine(5),cyclo(seryl-tryptophyl,6)、alanine(7)。 | 李想 姚燕华 孙光芝 林文翰 Isabel Sattler | 2007 | 天然产物研究与开发2007，19，5： | 9 |
| 2 | 红树植物内生真菌Penicillium sp.中两个甾体化合物的研究显示文摘从红树植物内生真菌Penicillium sp.的发酵液中分离纯化了两个甾体类化合物,通过各种波谱实验(1D-NMR,2D-NMR,ESI-MS)确定为:麦角甾-4,6,8(14),22-四烯-3-酮(1)和麦角甾-5,7,22-三烯-3-醇(2),1对于3α-HSD脱氢酶在250μm浓度下有较弱的活性。 | 李想 孙光芝 郑毅男 林文翰 Isabel Sattler | 2007 | 天然产物研究与开发2007，19，3： | 7 |
| 3 | 薄层层析指导下的嗜碱放线菌菌株YIMGQ-14次生代谢产物研究显示文摘在微生物资源的开发研究过程中 ,利用TLC方法 ,配合TLC数据库的检索 ,对嗜碱放线菌菌株YIMGQ1 4的次生代谢产物进行了研究。并从中分离纯化出两个具有生物活性的专利化合物“UmycinC”和“UmycinB”。结果证明 :相对于常规的生物活性筛选 ,TLC法在微生物次生代谢产物研究中具有快速、简便、经济的特点 ,适合于小量常规筛选的目的。通过进一步对相关的TLC数据库进行构建和补充 ,将能极大地改善该方法的使用效率。 | 李铭刚 Groth Ingrid 李一青 Sattler Isabel 文孟良 | 2003 | 微生物学报2003，43，4： | 7 |
| 4 | Epidemiology and genetics of ventricular fibrillation during acute myocardial infarction显示文摘从室的纤维性颤动(VF ) 的突然的心脏的死亡(SCD ) 在冠的动脉疾病(CAD ) 期间是全部、心血管的死亡的一个领先的原因,并且在里面多于 SCD 盒子的一半, VF 作为 CAD 的第一症状发生。几流行病学的研究证明了一个家庭成员的突然的死亡在尖锐心肌的梗塞(MI ) 期间是为 SCD 和 VF 的一个风险因素,独立于包括 MI 的家庭历史的传统的风险因素,在危险性建议一个基因部件到 VF。由于 MI 阻止 SCD 和 VF,我们需要在这张显然健康的人口引起 VF 的基因、分子的机制的更好的理解。尽管新卓见和技术变得可得到,到 VF 的基因倾向在 MI 期间仍然保持糟糕理解。,从许多不同基因研究的调查结果没能到达重制度几基因变体,普通、稀罕的变体,被联系了到 VF 或 SCD。为这评论,我们在 PubMed 找了潜在地相关的文章,用下列网孔术语:突然的心脏的死亡,室的纤维性颤动, out-of-hospital 心脏的拘捕,心肌的梗塞,心肌的局部缺血,冠的动脉疾病,和遗传。这评论由于 MI 为基因危险性描述传染病学和证据到 VF。 | Charlotte Glinge Stefan Sattler Reza Jabbari Jacob Tfelt-Hansen | 2016 | Journal of Geriatric Cardiology2016，13，9： | 6 |
| 5 | 红树植物内生真菌Penicillium s p.中一个醌类化学成分的研究显示文摘利用各种层析手段(反相ODS健合硅胶、葡聚糖凝胶LH-20柱层析等),从红树植物内生真菌Penicil-liumsp.的发酵液中分离纯化了1个醌类化合物,通过各种波谱实验(1D-NMR,2D-NMR以及ESIMS)确定其结构为:5-甲氧基-11,12,18,19-四羟基蒽醌(1)。 | 李想 姚燕华 孙光芝 郑毅男 林文翰 Isabel SATTLER | 2007 | 分析测试学报2007，26，2： | 5 |
| 6 | 一座像家一样的幼儿园--四叶草之家显示文摘四叶草之家是MAD在日本的第一个作品,在经过近一年的建造后,于2016年4月完工并投入使用。四叶草之家位于日本爱知县冈崎市,是一所由家族经营的儿童教育机构。为了向社区更多少儿提供教育服务,幼儿园的经营者决心将全家居住多年的家拆了,在原有的地块儿上建起新的幼儿园。 | 米津孝祐 李悠焕 藤野大树 Julian Sattler Davide Signorato Fuji Koji Dan Honda | 2016 | 建筑技艺2016，0，12： | 5 |
| 7 | 红树植物内生真菌GT6105发酵产物的化学成分显示文摘目的从红树植物内生真菌中寻找具有酶抑制活性的次生代谢产物。方法利用各种柱层析手段,结合各种波谱方法分离鉴定红树植物内生真菌GT6105的化学成分。结果从红树植物内生真菌GT6105发酵液中分离纯化了12个化合物邻苯二甲酸二乙基己酯(1),阿魏酸(2),3,5-二羟基甲苯(3),邻苯二甲酸丁酯(4),2-羟基-3-苯丙酸(5),2,3-二羟基甲苯(6),3,4,5-三羟基甲苯(7),5-甲氧基-2,3-二羟基甲苯(8),对羟基苯甲酸(9),2,2-二甲基-1-苯并吡喃-6-醇(10),2,2-二甲基-6-羧基-苯并吡喃(11),4-(4-甲酰-2-甲氧-1-苯氧基)丁酸(12)。结论化合物12为首次从天然界分得,化合物2、10和11具有较弱的酶抑制活性。 | 李想 姚燕华 郑毅男 林文翰 Isabel Sattler 邓志威 | 2007 | 中国天然药物2007，5，1： | 5 |
| 8 | Initial steroid-free immunosuppression after liver transplantation in recipients with hepatitis c virus related cirrhosis显示文摘AIM: Steroids can increase hepatitis C virus (HCV) replication. After liver transplantation (LTx), steroids are commonly used for immunosuppression and acute rejection is usually treated by high steroid dosages. Steroids can worsen the outcome of recurrent HCV infection. Therefore,we evaluated the outcome of HCV infected liver recipients receiving initial steroid-free immunosuppression.METHODS: Thirty patients undergoing LTx received initial steroid-free immunosuppression. Indication for LTx included 7 patients with HCV related drrhosis. Initial immunosuppression consisted of tacrolimus 2x0.05 mg/kg.d po and mycophenolate mofetil (MMF) 2x15 mg/kg.d po. The tacrolimus dosage wasa djusted to trough levels in the target range of 10-15 μg/Ldudng the first 3 mo and 5-10 μg/L thereafter. Manifestations of acute rejection were verified histologically.RESULTS: Patient and graft survival of 30 patients receiving initial steroid-free immunosuppression was 86% and 83% at 1 and 2 years. Acute rejection occurred in 8/30 patients,including 1 HCV infected recipient. All HCV-infected patients had HCV genotype II (lb). HCV seropositivity occurred within the first 4 mo after LTx. The virus load was not remarkably increased during the first year after LTx. Histologically, grafts had no severe recurrent hepatitis.CONCLUSION: From our experience, initial steroid-free immunosuppression does not increase the risk of acute rejection in HCV infected liver recipients. Furthermore, none of the HCV infected patients developed serious chronic liver diseases. It suggests that it may be beneficial to avoid steroids in this particular group of patients after LTx. | Perdita Wietzke-Braun Felix Braun Burckhart Sattler Giuliano Ramadori Burckhardt Ringe | 2004 | World Journal of Gastroenterology2004，10，15： | 5 |
| 9 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 10 | 嗜碱放线菌YIM-80147次生代谢产物的化学成分研究(英文)显示文摘对嗜碱放线菌YIM 80 14 7的发酵产物进行化学成分的研究 ,从中分离得到 6个化合物。根据光谱数据的分析 ,鉴定其结构分别为P371A2 (1) ,4 hydroxymethyl 3 (1 hydroxy 6 methyl heptyl) dihydro furan 2 one(2 ) ,nonacticacid(3) ,homononactinicacid(4 ) ,对羟基肉桂酸 (5 ) ,阿魏酸 (6 ) | 吴少华 ISABEL Sattler 李铭刚 李一青 文孟良 | 2004 | 天然产物研究与开发2004，16，4： | 3 |
| 11 | New ent-Isopimarane Diterpene from Mangrove Excoecaria agallocha L.显示文摘A new ent-isopimarane diterpenoid,Agallochaone A(1),together with the known 8,13-epoxy-14-labden-3-one(2)and Excoecarin B(3)were isolated from the whole plant of mangrove Excoecaria agallocha L.and identified on the basis of a detailed spectral analysis,including 2D NMR spectrometry and HRESI-MS. | LI Xiang LEI Jun ZHENG Yi-nan Sattler Isabel LIN Wen-han | 2007 | Chemical Research in Chinese Universities2007，23，5： | 3 |
| 12 | β-内酰胺类抗生素引起的止血功能障碍显示文摘最近10年来,扩大了抗菌谱的一些抗生素被批准用于临床。曾经预料这些新药会像以前用的青霉素类和头孢菌素类同样的安全;然而,已有戒酒硫(Disulfiram)反应,损害止血功能、出血,以及惊厥发作等报道,令人对这些β-内酰胺中某些新药的真实安全性,产生了关注。论及β-内酰胺类引起的出血频率,特别混乱,对这些药物引起止血功能缺陷的不同机制,也有误解,这偶或导致对β-内酰胺治疗的病人中发生的出血,给以不当的处理,所以我们认为,需要回顾这些问题。 | Sattler FR 胡丕华 | 1990 | 国外医药(抗生素分册)1990，11，2： | 3 |
| 13 | Characterization of novel Brown midrib 6 mutations affecting lignin biosynthesis in sorghum显示文摘The presence of lignin reduces the quality of lignocellulosic biomass for forage materials and feedstock for biofuels. In C4 grasses,the brown midrib phenotype has been linked to mutations to genes in the monolignol biosynthesis pathway. For example,the Bmr6 gene in sorghum(Sorghum bicolor) has been previously shown to encode cinnamyl alcohol dehydrogenase(CAD),which catalyzes the final step of the monolignol biosynthesis pathway. Mutations in this gene have been shown to reduce the abundance of lignin,enhance digestibility,and improve saccharification efficiencies and ethanol yields. Nine sorghum lines harboring five different bmr6 alleles were identified in an EMS-mutagenized TILLING population. DNA sequencing of Bmr6 revealed that the majority of the mutations impacted evolutionarily conserved amino acids while three-dimensional structural modeling predicted that all of these alleles interfered with the enzyme's ability to bind with its NADPH cofactor. All of the new alleles reduced in vitro CAD activity levels and enhanced glucose yields following saccharification. Further,many of these lines were associated with higher reductions in acid detergent lignin compared to lines harboring the previously characterized bmr6-ref allele. These bmr6 lines represent new breeding tools for manipulating biomass composition to enhance forage and feedstock quality. | Erin D. Scully Tammy Gries Deanna L. Funnell-Harris Zhanguo Xin Frank A. Kovacs Wilfred Vermerris Scott E. Sattler | 2016 | Journal of Integrative Plant Biology2016，58，2： | 3 |
| 14 | PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner显示文摘 | Franz Wolfgang Hirsch Bernhard Sattler Ina Sorge Lars Kurch Adrian Viehweger Lutz Ritter Peter Werner Thies Jochimsen Henryk Barthel Uta Bierbach Holger Till Osama Sabri Regine Kluge | 2013 | Pediatric Radiology2013，，： | 2 |
| 15 | Challenges and perspectives for structural biology of IncRNAs-the example of the Xist IncRNA A-repeats显示文摘Following the discovery of numerous long non-coding RNA(IncRNA)transcripts in the human genome,their important roles in biology and human disease are emerging.Recent progress in experimental methods has enabled the identification of structural features of IncRNAs.However,determining high-resolution structures is challenging as IncRNAs are expected to be dynamic and adopt multiple conformations,which may be modulated by interaction with protein binding partners.The X-inactive specific transcript(Xist)is necessary for X inactivation during dosage compensation in female placental mammals and one of the beststudied IncRNAs.Recent progress has provided new insights into the domain organization,molecular features,and RNA binding proteins that interact with distinct regions of Xist.The A-repeats located at the 5'end of the transcript are of particular interest as they are essential for mediating silencing ofthe inactive X chromosome.Here,we discuss recent progress with elucidating structural features of the Xist IncRNA,focusing on the A-repeats.We discuss the experimental and computational approaches employed that have led to distinct structural models,likely reflecting the intrinsic dynamics of this RNA.The presence of multiple dynamic conformations may also play an important role in the formation ofthe associated RNPs,thus influencing the molecular mechanism underlying the biological function of the Xist A-repeats.We propose that integrative approaches that combine biochemical experiments and high-resolution structural biology in vitro with chemical probing and functional studies in vivo are required to unravel the molecular mechanisms of IncRNAs. | Alisha NJones Michael Sattler | 2019 | Journal of Molecular Cell Biology2019，11，10： | 2 |
| 16 | Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6,11,16,and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women显示文摘 | Block SL Nolan T Sattler C | 2006 | Pediatrics2006，118，5： | 1 |
| 17 | LDL-Apheresis for the treatment of hyperchylomicronemia-induced pancreatitis 显示文摘 | Sattler AM Boek K Schmidt S | 2003 | Z Kardiol2003，92，3： | 1 |
| 18 | Description logics with aggregates and concrete domains显示文摘 | Baader F U Sattler | 2003 | Information Systems2003，28，8： | 1 |
| 19 | Critical role for Gab2 in transformation by BCR/ABL显示文摘 | Sattler M Mohi M G Pride Y B | | 0，，05： | 1 |
| 20 | The ex-pression level of the orphan nuclear receptor GCNF(germ cell nuclear factor) is critical for neuronal differ-entiation显示文摘 | Sattler U Samochocki M Maelicke A | 2004 | Mol Endocrinol2004，18，11： | 1 |
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