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| 1 | Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil显示文摘AIM: To establish whether virulence factor genes vacA and cagA are present in Helicobacter pylori (H. pylori) retrieved from gastric mucosa and dental plaque in pa-tients with dyspepsia. METHODS: Cumulative dental plaque specimens and gastric biopsies were submitted to histological exami-nation, rapid urease test and polymerase chain reac-tion (PCR) assays to detect the presence of cagA and vacA polymorphisms.RESULTS: Detection of H. pylori from dental plaque and gastric biopsy samples was greater by PCR com-pared to histological examination and the rapid ure-ase test. DNA from H. pylori was detected in 96% of gastric mucosa samples and in 72% of dental plaque samples. Sixty-three (89%) of 71 dental plaque sam-ples that were H. pylori-positive also exhibited identical vacA and cagA genotypes in gastric mucosa. The most common genotype was vacAs1bm1 and cagA positive, either in dental plaque or gastric mucosa. These viru-lent H. pylori isolates were involved in the severity of clinical outcome.CONCLUSION: These pathogenic strains were found simultaneously in dental plaque and gastric mucosa, which suggests that gastric infection is correlated with the presence of H. pylori in the mouth. | Mnica Baraúna Assumpo Luisa Caricio Martins Hivana Patricia Melo Barbosa Katarine Antonia dos Santos Barile Sintia Silva de Almeida Paulo Pimentel Assumpo Tereza Cristina de Oliveira Corvelo | 2010 | World Journal of Gastroenterology2010，16，24： | 29 |
| 2 | Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population显示文摘AIM:To study the association between Interleukin-1(IL-1)and tumor necrosis factor(TNF)-αpolymorphisms,infection by Helicobacter pylori(H pylori)and the development of gastrointestinal diseases.METHODS:Genomic DNA was extracted from the peripheral blood of 177 patients with various gastrointestinal diseases and from 100 healthy volunteers.The polymorphisms in IL-1βand TNF-αgenes were analyzed using the polymerase chain reactionrestriction fragment length polymorphism method(PCRRFLP)and those from IL-1RN with PCR.The presence of infection due to H pylori and the presence of the CagA toxin were detected by serology.The histopathological parameters in the gastric biopsies of the patients were according to the Sydney classification.RESULTS:A comparison of the frequencies of the different polymorphisms studied among the patients and the control group demonstrated that the allele IL1RN*2 was more frequent among patients with gastric ulcers and adenocarcinoma.Carriers of the allele ILRN*2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinoma,as well as a higher degree of inflammation and neutrophilic activity in the gastric mucosa.CONCLUSION:Our results indicate a positive association between IL-1RN gene polymorphism and infection by positive H pylori CagA strains and the development of gastric ulcers and adenocarcinoma. | Hivana Patricia Melo Barbosa Luisa Caricio Martins Sidney Emanuel Batista dos Santos Samia Demachki Mnica Baraúna Assumpo Charliana Damasceno Arago Tereza Cristina de Oliveira Corvelo | 2009 | World Journal of Gastroenterology2009，15，12： | 17 |
| 3 | Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats显示文摘 | dos Santos NA Martins NM Curti C | 2009 | Chem Biol Interact2009，170，3： | 1 |
| 4 | Wemer syndrome and mutations of the WRN and LMNA genes in France显示文摘 | Uhrhammer NA Lafarge L Dos Santos L | 2006 | Human Mutation2006，27，7： | 1 |
| 5 | Cisplatin-induced nephrotoxicity and targets of nephroprotection:an update显示文摘 | Dos Santos NA Carvalho Rodrigues MA Martins NM | | 0，，08： | 1 |
| 6 | Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress,redox state unbalance,impairment of energetic metabolism and apoptosis in rat kidney mitochondria 显示文摘 | SANTOS NA BEZERRA CS MARTINS NM | 2008 | Cancer Chemother Pharmacol2008，61，1： | 1 |
| 7 | Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment,membrane rigidification and apoptosis in rat liver显示文摘 | Martins NM Santos NA Curti C | | 0，，03： | 1 |
| 8 | Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment,membrane rigidification and apoptosis in rat liver显示文摘 | Martins NM Santos NA Curti C | | 0，，03： | 1 |
| 9 | Werner syndrome and mutations of the WRN and LMNA genes in France 显示文摘 | Uhrhammer NA Lafarge L Dos Santos L | 2006 | Hum Mutat2006，27，7： | 1 |
| 10 | Rat's age versus human's age:what is the relationship显示文摘 | Andreollo NA Santos EF Araújo MR | | 0，，01： | 1 |
| 11 | Hydroxylradical scavenger ameliorates cisplatin-inducednephrotoxicity by preventing oxidative stress, redox stateunbalance, impairment of energetic metabolism andapoptosis in rat kidney mitochondria 显示文摘 | Santos NA Bezerra CS Martins NM | 2008 | CancerChemother Pharmacol2008，61，1： | 1 |
| 12 | Complete Genome Sequence of Mycoplasma wenyonii Strain Massachusetts显示文摘 | Andrea P. dos Santos Ana M. S. Guimaraes Naíla C. do Nascimento Phillip J. SanMiguel Joanne B. Messick | 2012 | Journal of Bacteriology2012，，19： | 1 |
| 13 | Activity of Staphylococcal bacteriocins against Staphylococcus aureus and Streptococcus agalactiae Involved in Bovine Mastitis 显示文摘 | Marcus L1 ' vio Varella Coelho Janal ' na dos Santos Nascimento Patrl ' cia Carlin | 2007 | Research in Microbiology2007，158，7： | 1 |
| 14 | Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss 显示文摘 | Helene BL Santo L James NA | 1999 | Obstet Gynecol1999，94，： | 1 |
| 15 | Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus显示文摘 | Coelho EB Dos Santos NA Geleilete TJ Lanchote VL | 2002 | Eur J Clin Pharmacol2002，58，9： | 1 |
| 16 | Rat's age versus hu- man' s age: what is the relationship? 显示文摘 | Andreollo NA Santos EF Arafijo MR | 2012 | Arq Bras Cir Diq2012，25，： | 1 |
| 17 | Werner syndrome and mutations of the WRN and LMNA genes in France显示文摘 | Uhrhammer NA Lafarge L Dos Santos L | | 0，，： | 1 |
| 18 | Sick building syndrome in bank employees显示文摘 | Rumel D Martarello NA | 1992 | Rev Saude Publica1992，26，6： | 1 |
| 19 | Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats显示文摘 | Dos Santos NA Martins NM Curti C | 2007 | Chem Biol Interact2007，15，1701： | 1 |
| 20 | Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss显示文摘 | Helene BL Santo L James NA | 1999 | Obstet Gynecol1999，94，： | 1 |
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