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| 1 | Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene显示文摘瞄准:在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度,以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法:95 个 GS 盒子和 95 正常控制被选择。肝工作,另外的测试被做。倡导者和 UGT1A1 基因的所有 5 前 ons 被重新定序。对新奇 trinucleotide 插入的功能的评价被做由在 silico 分析并且由估计 UGT1A1,倡导者活动在 Hep G2 由适当构造的酶记者试金执行了房间线。结果:在 GS 病人之中, 80% 为 TA 插入是同型结合的,它比从另外的种族组的报告高好几倍。吝啬的 UCB 水平与仅仅这插入的一个拷贝在个人之中被提高,它不与有二个拷贝的那些显著地不同。在 UGT1A1 基因的许多新 DNA 变体被发现,包括在倡导者的插入在 GS 病人的一个子集(10%) 发现了的 trinucleotide (猫) ,然而并非在正常之中控制。In-silico 分析证明在倡导者和功能的分析的合拢 DNA 的显著变化在 UGT1A1 基因源于这插入的抄写效率显示出 20 褶层减小,显著地从而提高 UCB 水平。结论:GS 的基因传染病学越过种族组是可变的,在 UGT1A1 倡导者变体之中的上位相互作用调制胆红素 glucuronidation。 | Shabana Farheen Sanghamitra Sengupta Amal Santra Suparna Pal Gopal Krishna Dhali Meenakshi Chakravorty Partha P Majumder Abhijit Chowdhury | 2006 | World Journal of Gastroenterology2006，12，14： | 29 |
| 2 | Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines显示文摘Objective: To evaluate the cytotoxic effects of Spirulina platensis extracts on acute leukemia Kasumi-1 and chronic leukemia K-562 cancer cell lines.Methods: Various concentrations of Spirulina platensis extracts(0.25–50.00 mg/m L)obtained with different solvents were used to treat cell lines for 72 h. For cytotoxic effect studies, cell viability test with trypan blue solution, MTT assay and microscopic cytomorphological assessment were done.Results: Spirulina extract obtained with 70% ethanol showed significant cytotoxicity in K562 and Kasumi-1 cell lines. With trypan blue solution, IC_(50) values were found to be4.64 mg/m L for K-562 and 3.68 mg/m L for Kusumi-1 cell lines. Spirulina aqueous extract also showed cytotoxicity with trypan blue method, at a slightly higher dose; where IC_(50) values were 12.68 mg/m L for K-562 and 2.13 mg/m L for Kusumi-1 cell lines. The IC_(50) values were found 0.40 mg/m L for K-562 and 0.31 mg/m L for Kusumi-1 cell lines for the 70% ethanol extract according to the MTT assay. Spirulina extract obtained with water also showed cytotoxicity but the dose was a little higher where IC_(50) values were15.77 mg/m L for K-562 and 9.44 mg/m L for Kusumi-1 cell lines. The effect of cytotoxicity with ethanol extract is quite comparable with that observed for cyclophosphamide, which is a chemical used as anticancer agent.Conclusions: The cytotoxicity exhibited by Spirulina extract to cancer cell lines might be due to the presence of phytopigments(carotenoids, chlorophyll, phycocyanin) as well as polysaccharides that were reported previously as constituents of the extract. So crude extracts of Spirulina can be used as a source to develop anticancer drugs. | Flor Yohana Flores Hernandez Sanghamitra Khandual Inocencia Guadalupe Ramírez López | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 4 |
| 3 | Textural and geochemical characteristics of off shore sediment of North Bay of Bengal:A statistical approach for marine metal pollution显示文摘Metal pollution study on sediments of North Bay of Bengal sediments presented in this paper is based on existing Lithostratigraphy of upstream,mineralogy and geochemical analysis of 42 sediment samples.The statistical analysis identifies the metal pollution as well as its apparent source in the off shore regions.Samples were analyzed for grain size,organic content and heavy metals(Fe,Mn,Cr,Cu,Ni,Pb,Cd,Zn and Co) using the sequential extraction method to evaluate geochemical processes and pollution load.In an effort to surmise anthropogenic input,several approaches including classification by quantitative indexes such as enrichment factor,contamination factor,degree of pollution,pollution load index and geo accumulation index,were attempted.Metal speciation results indicate high%of Cd in exchangeable fraction of Mahanadi transect sediments where as a considerable amount of oxidizable fraction of Cr was detected at Dhamra.Quantitative indexes place North Bay of Bengal under moderately polluted zone due to high level of Cd.Normalization of metals to Fe indicated relatively high enrichment factors for Cd and Cr.Factor analysis identified seven possible types of geochemical associations where sediment pH plays a major role for the heavy metal mobility.The higher Cd concentration in exchangeable fraction as well as the higher EF for Cd and Cr present in sediment may pose a risk of secondary water pollution under slightest disturbance in the geo-chemistry of sediments.Comparison study with available data of near costal zones and upstream stratigraphy revealed that open cast mining,overburden dumping,mineral based industrial effluents were the major source of pollution for catchment area contamination.Bay of Bengal is likely to face a serious threat of metal pollution with the present deposition rates unless rigorous pollution control norms are applied. | Sanghamitra Palleyi Sabnam Banoo Rabi Narayan Kar Chitta Ranjan Panda | 2015 | International Journal of Sediment Research2015，30，3： | 3 |
| 4 | miRT:A Database of Validated Transcription Start Sites of Human MicroRNAs显示文摘MicroRNAs (miRNAs ) 是在长度的大约 22 nt 的小内长的非编码的 RNA 在许多生物过程起关键作用。这些短 RNA 由绑定调整 mRNAs 的表示到他们的 3-UTRs 或由翻译压抑。许多在怎么成熟上当前的研究集中 miRNAs 然而,调整 mRNAs 很有限的知识关于他们的 transcriptional loci 是可得到的。主要 miRNAs (pri 米尔) 首先从 DNA 被抄录,这被知道,由 endonuclease 活动由先锋 miRNAs (米尔前) 的形成列在后面,它最后生产成熟 miRNAs。到日期为止,许多试验性地米尔前和成熟 miRNAs 被验证了。但是不幸地, pri 米尔,倡导者和联系抄写开始地点(TSS ) 的 loci 的鉴定仍然在进行中。在人的仅仅大约 40% 已知的成熟 miRNAs 的 TSS 被报导了。这个信息,限制的虽然,可能为 miRNAs 的规定的进一步的学习有用。在这份报纸,我们提供验证 miRNA TSS 的一个新奇数据库, miRT,由从验证 miRNA TSS 的几试验性的研究收集数据并且为完整的下载是可得到的。我们一个网服务者和它也是可能的变换在不同染色体之间的 TSS loci 的现在的 miRT 造了。miRT 可能是为关于 miRNA 规定的先进研究的一个珍贵资源,它是自由地可存取的在:http://gffzzfd211068447f4ce4hfwwwfqc0u0ku6ku0.ffgz.tsg.suse.edu.cn/~bioinfo_miu/miRT/miRT.php。 | Malay Bhattacharyya Manali Das Sanghamitra Bandyopadhyay | 2012 | Genomics, Proteomics & Bioinformatics2012，10，5： | 3 |
| 5 | Biotechnological intervention in Betelvine(Piper betle L.):A review on recent advances and future prospects显示文摘Betelvine(Piper betle L.) is cultivated for its deep green heart shaped leaf for(15-20) million Indian and 2 billion foreign consumers annually. The crop provides Rs(6 000-7 000) million of national income per year and at the same time leaves worth Rs(30-40) million is exported to other countries. The leaves are not only used directly for chewing purposes but also possesses antioxidant, anti-inflammatory, anti-apoptotic, anti-cancer and anti-microbial properties. Besides, the leaves also contain eugenol rich essential oil(1%-3%) which is the source for medicine, stimulant, antiseptic, tonic and other ayurvedic formulations. The essential oil also contains chavibetol, caryophyllene and methyl eugenol which are the potent source for preparation in ayurvedic medicine and herbal products. Cost of betelvine essential oil is 10$ per 5 mL. In spite of its great economical and medicinal importance betelvine is still neglected by the researchers for proper characterization and authentication for selection of elite landraces. Lack of awareness among people, use of same planting material for many generations, existing of many synonyms for a single landraces, no proper characterization of available landraces are some of the significant constraints for its commercialization. Our review endeavours a complete advance in the research on betelvine, existing lacunae for its proper characterization and commercial cultivation. It also attempts to provide a comprehensive account on biotechnological interventions made in betelvine aimed at complementing conventional programmes for improvement of this nutraceutically important cash crop. | Suryasnata Das Reena Parida I.Sriram Sandeep Sanghamitra Nayak Sujata Mohanty | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 2 |
| 6 | Curcuma angustifolia ameliorates carbon tetrachloride-induced hepatotoxicity in HepG2 cells and Swiss albino rats显示文摘Objective:To determine the antioxidant and hepatoprotective potential of methanol extract of rhizome of Curcuma angustifolia(MECA)against carbon tetrachloride(CCl4)-induced hepatic damage in vitro and in vivo.Methods:DPPH,ABTS and reducing power assays were performed to estimate the antioxidant effect of MECA.In vitro cytotoxicity of MECA against HepG2 cells was evaluated,whereas serum biochemical parameters and levels of antioxidative enzymes were measured in vivo and in vitro.Additionally,histopathological studies were estimated in order to investigate the hepatoprotective efficacy of MECA.Furthermore,GC-MS analysis of the extract was performed to identify the chemical components.Results:MECA exhibited strong antioxidant activity and attenuated CCl4-induced decrease in the viability of HepG2 cells.Additionally,MECA significantly restored the ALT,AST,ALP,TP and albumin level in comparison with the CCl4 group.After pre-treatment with MECA,effects of SOD,CAT and GSH were increased as well as lipid peroxidation amount decreased on CCl4-induced hepatotoxicity in in vitro and in vivo model.Furthermore,histopathological observation confirmed that MECA reduced liver injury induced by CCl4 in rats.GC-MS analysis confirmed the presence of bioactive constituents such as α-tocopherol(12.27%),phytol(7.61%),squalene(3.71%),β-sitosterol(2.19%),eugenol(2.59%),curcumenol(1.20%),β-elemene(1.00%)and eucalyptol(0.89%).Conclusions:MECA contains antioxidant and hepatoprotective constituents such asα-tocopherol,phytol,squalene and eugenol and exerts hepatoprotective effect both in vitro and in vivo. | Sudipta Jena Asit Ray Diptirani Rath Ambika Sahoo Subhashree Singh Noohi Nasim Durga Madhab Kar Sanghamitra Nayak | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，9： | 2 |
| 7 | phytochemical investigation and in vitro antioxidant activity of an indigenous medicinal plant Alpinia nigra B.L.Burtt显示文摘Objective:To investigate antioxidant potential of methanol extract of Alpinia nigra leaves.Methods:The study was done by using various in vitro methods such as 1,1-diphenyl-2-picrylhydrazyl(DPPH),2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS),nitric oxide and hydrogen peroxide radical scavenging assays.Phytochemical constituents,total phenolic content and total flavonoid content of the extract at different concentrations(10-500μg/mL)were determined.Results:Alpinia nigra leaves showed high free radical scavenging activity as evidenced by the low IG_(50)values in DPPH(64.51μg/mL),in ABTS(28.32μg/mL),in nitric oxide(80.02μg/mL)and in H_2O_2(77.45μg/mL)scavenging assays.Furthermore the TPC and TFC of the extract were found to be 69.25 mg gallic acid equivalent per gram of extract and 78.84 mg quercetin equivalent per gram of extract respectively.Conclusions:The results of present comprehensive analysis demonstrated that Alpinia nigra leaves possess high phenolic,flavonoid contents and potential antioxidant activity,and could be used as a viable source of natural antioxidants and might be exploited for functional foods and neutraceutical applications. | Suprava Sahoo Goutam Ghosh Debajyoti Das Sanghamitra Nayak | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，11： | 2 |
| 8 | Fire monitoring in coal mines using wireless underground sensor network and interval type-2 fuzzy logic controller显示文摘From the view of underground coal mining safety system, it is extremely important to continuous monitoring of coal mines for the prompt detection of fires or related problems inspite of its uncertainty and imprecise characteristics. Therefore, evaluation and inferring the data perfectly to prevent fire related accidental risk in underground coal mining (UMC) system are very necessary. In the present article, we have proposed a novel type-2 fuzzy logic system (T2FLS) for the prediction of fire intensity and its risk assessment for risk reduction in an underground coal mine. Recently, for the observation of underground coal mines, wireless underground sensor network (WUSN) are being concerned frequently. To implement this technique IT2FLS, main functional components are sensor nodes which are installed in coal mines to accumulate different imprecise environmental data like, temperature, relative humidity, different gas concentrations etc. and these are sent to a base station which is connected to the ground observation system through network. In the present context, a WUSN based fire monitoring system is developed using fuzzy logic approach to enhance the consistency in decision making system to improve the risk chances of fire during coal mining. We have taken Mamdani IT2FLS as fuzzy model on coal mine monitoring data to consider real-time decision making (DM). It is predicted from the simulated results that the recommended system is highly acceptable and amenable in the case of fire hazard safety with compared to the wired and off-line monitoring system for UMC. Legitimacy of the suggested model is prepared using statistical analysis and multiple linear regression analysis. | Sweta Basu Sutapa Pramanik Sanghamitra Dey Gautam Panigrahi Dipak Kumar Jana | 2019 | International Journal of Coal Science & Technology2019，6，2： | 2 |
| 9 | Multi-Objective particle swarm optimization with time variant inertia and acceleration coefficents显示文摘 | Praveen Kumar Tripathi Sanghamitra Bandyopadhyay and Sankar Kumar Pal | 2007 | Information Sciences2007，177，22： | 1 |
| 10 | Activity-based Costing for Logistics and Marketing显示文摘 | STAPLETON D SANGHAMITRA P ERIK B | 2004 | Business Process Management Journal2004，10，5： | 1 |
| 11 | An Automatic Shape Independent Clustering Technique显示文摘 | Sanghamitra Bandyopadhyay | 2004 | Pattern Recognition2004，37，： | 1 |
| 12 | Antimicrobial assay of Stevia rebaudiana Bertoni leaf extracts against 10 pathogens显示文摘 | Sumit Ghosh Enketeswara Sududhi Sanghamitra Nayak | 2008 | Int J Integrative Bio2008，2，1： | 1 |
| 13 | Genetic clustering for automatic evolution of clusters and application to image classification显示文摘 | SANGHAMITRA B UJJWAL M | 2002 | Pattern Recognition2002，35，6： | 1 |
| 14 | Genetic algorithm- based clustering technique显示文摘 | Ujjwal Maulik Sanghamitra Bandyopadhyay | 2000 | Pattern Recognition2000，，33： | 1 |
| 15 | Multiobjective Genetic Clustering for Pixel Classification in Remote Sensing Imagery 显示文摘 | Sanghamitra B Ujjwal M Anirhan M | 2007 | IEEE Transactions on Geoseienee and Remote Sensing2007，45，5： | 1 |
| 16 | Genetic Algorithm Based Clustering Technique显示文摘 | Sanghamitra B | 2000 | Patten Recognition2000，33，9： | 1 |
| 17 | Development of temperature-tolerant strains of thioxidans ferrooxidans to improve bioleaching kinetics 显示文摘 | Jayant M Modak Natarajan K A Sanghamitra Mukhopadhyay | 1996 | Hydrometallurgy1996，，42： | 1 |
| 18 | Involvement of the Akt/PKB signaling pathway with disease processes显示文摘 | Prosenjit Sen Sebanti Mukherjee Doel Ray Sanghamitra Raha | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 19 | Genetic algodthm- based clustering technique 显示文摘 | UJJWAL M SANGHAMITRA B | 2000 | Pattern Recognition2000，33，9： | 1 |
| 20 | Genetic algo- rithm-based clustering technique 显示文摘 | Ujjwal Maulik Sanghamitra Bandyopadhyay | 1999 | Patter Recogintion1999，33，2000： | 1 |
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