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| 1 | Alginate and alginate composites for biomedical applications显示文摘Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp.and Pseudomonas sp.Owing to alginate gel forming capability,it is widely used in food,textile and paper industries;and to a lesser extent in biomedical applications as biomaterial to promote wound healing and tissue regeneration.This is evident from the rising use of alginate-based dressing for heavily exuding wound and their mass availability in the market nowadays.However,alginate also has limitation.When in contact with physiological environment,alginate could gelate into softer structure,consequently limits its potential in the soft tissue regeneration and becomes inappropriate for the usage related to load bearing body parts.To cater this problem,wide range of materials have been added to alginate structure,producing sturdy composite materials.For instance,the incorporation of adhesive peptide and natural polymer or synthetic polymer to alginate moieties creates an improved composite material,which not only possesses better mechanical properties compared to native alginate,but also grants additional healing capability and promote better tissue regeneration.In addition,drug release kinetic and cell viability can be further improved when alginate composite is used as encapsulating agent.In this review,preparation of alginate and alginate composite in various forms(fibre,bead,hydrogel,and 3D-printed matrices)used for biomedical application is described first,followed by the discussion of latest trend related to alginate composite utilization in wound dressing,drug delivery,and tissue engineering applications. | Raha Ahmad Raus Wan Mohd Fazli Wan Nawawi Ricca Rahman Nasaruddin | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 11 |
| 2 | Application of Stool-PCR test for diagnosis of Helicobacter pylori infection in children显示文摘AIM:To evaluate the usefulness of stool-PCR test for diagnosis of Helicobacter pylori(H pylori)infection in pediatric populations. METHODS:Based on endoscopic features(including nodular gastritis,erosive duodenitis and ulcer)and/or a positive rapid urease test(RUT)obtained during endoscopy,28 children from a group of children admitted to the Children's Medical Center of Tehran for persistent upper gastrointestinal problems were selected to compare biopsy-based tests with stoolPCR.Their gastric activity and bacterial density were graded by the updated Sydney system,and their first stool after endoscopy was stored at-70℃.Biopsies were cultured on modified campy-blood agar plates and identified by gram-staining,biochemical tests,and PCR.Two methods of phenol-chloroform and boiling were used for DNA extraction from H pylori isolates. Isolation of DNA from stool was performed using a stool DNA extraction kit(Bioneer Inc,Korea).PCR was performed using primers for detection of vacA,cagA,and 16srRNA genes in both isolates and stool. RESULTS:Sixteen out of 28 child patients(57%) were classified as H pylori positive by biopsy-based tests,of which 11(39%)were also positive by stoolPCR.Sensitivity and specificity of stool-PCR was 62.5% and 92.3%respectively.H pylori was observed in histological sections for 10 out of 11 stool-positivepatients.Association was observed between higher score of H pylori in histology and positivity of stoolPCR.Also association was observed between the more severe form of gastritis and a positive stool-PCR. CONCLUSION:Association between higher score of H pylori in histology and a positive stool-PCR make it a very useful test for detection of H pylori active infection in children.We also suggest that a simple stool-PCR method can be a useful test for detection of H pylori virulence genes in stool. | Tahereh Falsafi Raha Favaedi Fatemeh Mahjoub Mehri Najafi | 2009 | World Journal of Gastroenterology2009，15，4： | 5 |
| 3 | A study on gun propellants based on butyl- NENA显示文摘 | Chakraborthy T K Raha K C Omprakash B | 2004 | Energetic Materials2004，21，： | 1 |
| 4 | A pilot trial of combination cisplatin,5-fluorouracil and interferon-α in the treatment of advanced esophageal carcinoma显示文摘 | Bazqrbashi S Raha lM Raja MA | 2002 | Chemotherapy2002，48，4： | 1 |
| 5 | Admission Control for Hard Real-Time Connections in ATM IANS 显示文摘 | RAHA A ZHAO W KAMAT S | 2001 | IEEE Proc Commun2001，148，4： | 1 |
| 6 | Capturability analysis of a 3-D retro-PN guidance law for higher speed nonmaneuvering targets 显示文摘 | Ghosh S Ghose D Raha S | 2014 | IEEE Transactions on Control Systems Technology2014，22，5： | 1 |
| 7 | Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leu- kemia (CML) cells results in the downregulation of Hsp70显示文摘 | Mustafi S B Chakraborty P K Raha S | 2010 | PLoS ONE2010，5，1： | 1 |
| 8 | Mitochondria, Oxygen free radicals, disease and ageing 显示文摘 | Raha S Robinson B H | 2000 | Trends in Biochemical Sciences2000，25，10： | 1 |
| 9 | Cleroinemain, a neo-clerodane diterpenoid from Clerodenron inermi 显示文摘 | Raha P Das A Adrryachudhuri N | 1991 | Phytochemistry1991，30，11： | 1 |
| 10 | Neurocognitive and neurobehavioral disabilities in epilepsy with electrical status epilepticus in slow sleep (ESES) and related syndromes显示文摘 | Raha S Shah U Udani V | 2012 | Epilepsy Behav2012，25，3： | 1 |
| 11 | Mitoehondfia, oxygen free radicals, disease and ageing 显示文摘 | RAHA S ROBINSON B H | 2000 | Trends in Biochemical Sciences2000，25，10： | 1 |
| 12 | KRDS-a tetrapeptide derived from lactotransferrin-inhibits binding of mono- elonal antibody against glycoprotein IIb-IIIa on ADP-stimulated platelets and megakaryocytes 显示文摘 | Raha S Doquet C Abgrall J | 1988 | Blood1988，72，： | 1 |
| 13 | The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation 显示文摘 | Raha D Wilson T R Peng J | 2014 | Cancer Res2014，74，13： | 1 |
| 14 | Formulation For Viscoelastic Response Of Pavements Under Moving Dynamic Loading显示文摘 | PAPAGIANNAKIS A T RAHA R | 1998 | Journal of Transportion Engineering1998，122，2： | 1 |
| 15 | Evidence for a functional interaction between the CLC-2 chloride channel and the retrograde motor dynein complex 显示文摘 | Sonja UD Raha MP Najma AP | 2003 | The Journal of Biological Chemistry2003，278，16： | 1 |
| 16 | Mitochondria, oxygen free radical, and apoptosis显示文摘 | RAHA S ROBINSON B H | 2001 | Seminars in Medical Genetics2001，106，： | 1 |
| 17 | Mitochondria, oxygen free radicals, disease and ageing显示文摘 | Raha S Robinson BH | 2000 | Trends Biochem Sci2000，25，10： | 1 |
| 18 | Antibiotic resistance and plasmid profiling of Vibrio parahaemolyticus isolated from cockles in Padang 显示文摘 | Zulkifli Y Alitheen NB Raha AR | 2009 | Indonesia Intl Food Res J2009，16，： | 1 |
| 19 | Deteriorative changes of maize, groundnu- tand soybean seeds by fungi in storage显示文摘 | Bhattacharya K Raha S | 2002 | Mycopathologia2002，155，： | 1 |
| 20 | Repopulation of rho0 cells with mito- chondria from a patient with a mitochondrial DNA point mutation in tRNAGIy re- suits in respiratory chain dysfunction 显示文摘 | Raha S Merante F Shoubridge E | 1999 | Hum Mutat1999，13，3： | 1 |
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