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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates显示文摘High-fat diets affect male reproduction and sexual function.Therefore,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria diet.Male Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)groups.At 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 months.Animals were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further analysis.Data were analyzed by one-way ANOVA,and P<0.05 was considered statistically significant.The CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C group.However,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis. | Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio Bianca M Gregorio | 2019 | Asian Journal of Andrology2019，21，2： | 2 |
| 4 | Damage detection using the frequency-response-function curvature method 显示文摘 | Sampaio R P C Maia N M | 1999 | Journal of Sound and Vibration1999，226，： | 1 |
| 5 | Primary chemotherapy effect in sentinel node detection in breast cancer显示文摘 | Vigario A Sapienza M T Sampaio A P Piato J R Barros N Barros A | 2003 | Clin Nucl Med2003，28，： | 1 |
| 6 | Preparation and characterization of (3-aminopropyl)triethoxysilane-coated magnetite nanoparticles显示文摘 | M Yamaura R.L Camilo L.C Sampaio M.A Macêdo M Nakamura H.E Toma | 2004 | Journal of Magnetism and Magnetic Materials2004，，2： | 1 |
| 7 | Evaluation of the main MPPT techniques for photovoltaic applications显示文摘 | De Brito M A G Galotto L Sampaio L P | 2013 | IEEE Transactionson Industrial Electronics2013，60，3： | 1 |
| 8 | Activated carbons treated with sulphuric acid : Catalystsfor catalytic wet peroxide oxidation显示文摘 | Gomes Helder T Miranda Sandra M Sampaio Maria J etal | 2010 | Catal Today2010，151，12： | 1 |
| 9 | Use of punica granatumas an antifungal agent against candidosis associated with denture stomatitis显示文摘 | VASCONCELOS L C SAMPAIO M C SAMPAIO F C | 2003 | Mycoses2003，46，56： | 1 |
| 10 | Metal concentrations in surface water and sediments from Pardo River,Brazil:human health risks显示文摘 | Alves RI Sampaio CF Nadal M | 2014 | Environ Res2014，133，： | 1 |
| 11 | Vibrations of axially moving flexible beams made of functionally graded materials显示文摘 | Piovan M T Sampaio R | 2008 | Thin-Walled Structures2008，46，2： | 1 |
| 12 | Evalua- tion of the Main MPPT Techniques for Photovoltaie Applications显示文摘 | Brito M A Galotto L Sampaio L P | 2013 | IEEE Transactions on Industrial E- lectronics2013，60，3： | 1 |
| 13 | Left ventricular dias- tolic dysfunction and E/E' ratio as the strongest echocardiographic pre- dictors of reduced exercise capacity after acute myocardial infarction 显示文摘 | Fontes-Carvalho R Sampaio F Teixeira M | 2015 | Clin Cardiol2015，38，4： | 1 |
| 14 | Coupled axial/torsional vibrations of drill-strings by means of non-linear model显示文摘 | SAMPAIO R PIOVAN M T LOZANO G V | 2007 | Mechanics Research Communications2007，34，56： | 1 |
| 15 | Factors associated wilh return to work following a hand injury:a qualilative/quantitalive approach显示文摘 | Cabral L H Sampaio R F Figueiredo 1 M | 2010 | Rev Bras Fisiotcr2010，14，2： | 1 |
| 16 | Pulmonary involvement in ankylosing spondylitis显示文摘 | SAMPAIO - BARROS P D CERQUEIRA E M REZENDE S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 17 | Human exposure to heavy metals in the vicinity of Portuguese solid waste incinerators- Part 1: Biomonitoring of Pb, Cd and Hg in blood of the general population 显示文摘 | Reis M F Sampaio C Brantes A | 2007 | International Journal of Hygiene and Environmental Health2007，210，34： | 1 |
| 18 | Damage detection using the frequency-response-function curvature method显示文摘 | Sampaio R P C Maia N M M Silva J M M | 1999 | Journal of Sound and Vibration1999，，5： | 1 |
| 19 | Microsatellites for the mangrove tree Avicennia germinans (Acanthaceae):Tools for hybridization and mating system studies显示文摘 | Mori G M Zucchi M I Sampaio I | 2010 | American Journal of Botany2010，97，： | 1 |
| 20 | Effect of natural antioxidant combinations on lipid oxidation in cooked chicken meat during refrigerated storage显示文摘 | Sampaio G R Saldanha T Soares R A M | 2012 | Journal of Agri- culture and Food Chemistry2012，135，3： | 1 |
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