|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 3 | 以大剂量或低剂量二磷酸氯喹作为新型冠状病毒肺炎住院患者辅助治疗的临床疗效显示文摘至今尚没有推荐用于新型冠状病毒肺炎(COVID-19)的特异性抗病毒药物。细胞研究表明,高浓度二磷酸氯喹(CQ)可发挥抗病毒作用。该研究评估了2种CQ剂量在重症COVID-19患者中的安全性和有效性,为平行、双盲、随机的Ⅱb期临床试验,收录81例COVID-19成年患者。试验基地为巴西亚马逊马瑙斯市的三级医疗机构。试验时间为2020年3月23日至4月5日。 | 胡骢(编译) Borba MGS Val FFA Sampaio VS | 2020 | 中华医学杂志2020，100，41： | 20 |
| 4 | Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy显示文摘Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer's disease and Parkinson's disease as well as their putative application as new therapeutic approach for these diseases management. | Tuane Bazanella Sampaio Anne Suely Savall Maria Eduarda Ziani Gutlerrez Simone Proton | 2017 | Neural Regeneration Research2017，12，4： | 16 |
| 5 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 6 | Non-pharmacological cognitive intervention for aging and dementia:Current perspectives显示文摘In recent years, cognitive difficulties associated with normal aging and dementia have been receiving increased attention from both public and scientific communities. With an increase in overall lifespan, promoting healthy cognition has become a priority and a necessity for minimizing and preventing individual and societal burdens associated with cognitive dysfunctions in the elderly. The general awareness concerning the efficacy of preventive(e.g., lifestyles) and palliative treatment strategies of cognitive impairments, related to either healthy or unhealthy trajectories in cognitive aging, is continuously rising. There are several therapeutic strategies which can be broadly classified as either pharmacological or non-pharmacological/psychosocial. In face of the modest evidence for success of pharmacological treatments, especially for dementia related impairments, psychosocial interventions are progressively considered as a complementary treatment. Despite the relative spread of psychosocial interventions in clinical settings, research in this area is rather scarce with evidence for success of these therapies remaining controversial. In this work we provide an evidence based perspective on cognitive intervention(s) for healthy aging, pre-dementia(mild cognitive impairment), and dementia populations. Current evidence and future directions for improving cognitive functions in the elderly are discussed as well. | Jorge Alves Rosana Magalh?es álvaro Machado óscar F Gon?alves Adriana Sampaio Agavni Petrosyan | 2013 | World Journal of Clinical Cases2013，1，8： | 8 |
| 7 | 颅底骨折患者预防性使用抗生素预防脑膜炎的系统评价(英文)显示文摘目的 评价颅底骨折患者预防性使用抗生素预防脑膜炎的效果。方法 检索Cochrane临床对照试验资料库(CENTRAL)(Cochrane图书馆2005年第3期)、MEDLINE(1966~2005.09)、EMBASE(1974~2005.06)和LILACS(1982~2005.09)。电子检索美国神经外科医师协会会议记录(1997~2005.09),手工检索神经外科学会欧洲联合会会议记录摘要(1995,1999,2003)。收集比较抗生素与安慰剂或空白对照的随机对照试验。同时对检出的非随机对照试验单独进行Meta分析以比较结果。至少由两名研究者独立评价每项试验的质量并提取数据。采用RevMan4.2软件进行Meta分析。结果 纳入的5个随机对照试验和17个非随机对照试验比较了颅底骨折患者使用不同类型的预防性抗生素与安慰刹或空白对照的效果。但多数试验对方法学细节描述不充分。所有试验均将脑膜炎纳入其主要结局。共评价了符合Meta分析纳入标准的四个随机对照试验,共包括208例受试者。在降低脑膜炎的发生率、全因病死率、脑膜炎病死率和需要手术干预的脑脊液漏的发生率等方面,预防性抗生素组与对照组无显著差异。对伴或不伴脑脊液漏的患者进行亚组分析以评价其主要结局,并对所有检出的非随机对照试验(共包括2168例受试者)进行Meta分析,得出的结果与随机数据一致。 结论 现有的随机对照试验证据并不支持对颅底骨折患者预防性使用抗生素,无论其有无脑脊液漏的迹象。在更多的研究完成之前,尚无法确定颅底骨折患者使用抗生素的效果,因为迄今发表的研究均存在偏倚,尚需更多设计完善的大样本随机对照试验。 | Ratilal B Costa J Sampaio C 陈耀龙(译) 刁骧(审校) | 2006 | 中国循证医学杂志2006，6，8： | 7 |
| 8 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 9 | Left ventricular function assessment in cirrhosis:Currentmethods and future directions显示文摘Cirrhotic cardiomyopathy has been defined as a chronic cardiac dysfunction in patients with cirrhosis characterized by impaired contractile responsiveness to stress and/or altered diastolic relaxation with electrophysiological abnormalities in the absence of other known cardiac disease.Non-invasive cardiovascular imaging modalities play a major role in unmasking systolic and diastolic dysfunction in patients with cirrhosis.Echocardiography has been the most commonly used modality for assessing myocardial function in these patients.Conventional echocardiographic indices rely on several assumptions that may limit their applicability in patients with a hyperdynamic circulation.Newer imaging modalities may contribute to a more accurate diagnosis of cardiovascular abnormalities in cirrhotic patients,thereby influencing clinical management.We aimed to review the different non-invasive imaging technologies currently used for assessing left ventricular systolic and diastolic function in cirrhosis,as well as to describe new imaging modalities with potential clinical applicability in the near future. | Francisco Sampaio Joana Pimenta | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 10 | Duration and intensity of rainfall events with the same erosivity change sediment yield and runoff rates显示文摘The effect of different rainfall patterns on surface runoff,infiltration and thus soil losses and sediment concentrations are still in the focus of current research.In most simulated rainfall experiments,pre-cipitation is applied at a fixed intensity for a fixed time.However,the impact of rainfall patterns on soil erosion processes may be different varying the rainfall duration and intensity that produces an event with similar rainfall erosivity values.Twenty-five rainfall events were applied on micro-scale runoff plots in a soil covered with corn straw to evaluate the sediment yield and runoff rates.The different rainfall types were composed by association of duration(Dur)and intensity(IP)with the same erosivity value.The Dur varied from 38 to 106 min and the IP varied from 75.0 to 44.6 mm h^(-1).The sediment yield varied from 1.89±1.26 g m^(-2) to 4.02±2.66 g m^(-2) and runoff ranged from 16.9±8.74 mm to 32.63±10.67 mm with highest rates occurring with high intensity and low duration.The highest rainfall intensity provides the maximum sediment yield(0.138 g m^(-2) min^(-1))and runoff rates(0.87 mm min^(-1)).The time to start surface runoff varied from 14 to 19.2 min and it was longer in treatments with longer durations and low precipitation intensity.No difference was found in the amount of sediments applying rain with the same erosivity and different associations of duration and intensity.However,the intensity and duration of the rain,with the same erosivity,altered the amount and time of runoff.In rainfall experiments with con-stant intensity and fixed time,the erosion rates depend on the duration of the applied rain.Therefore,the results of this study can contribute to the development of new perspectives in the design of water erosion experiments with simulated rain considering the duration,intensity and also the association of these variables to produce rainfall that delivery the same soil erosion capacity. | Wilk Sampaio de Almeida Steffen Seitz Luiz Fernando Coutinho de Oliveira Daniel Fonseca de Carvalho | 2021 | International Soil and Water Conservation Research2021，9，1： | 4 |
| 11 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 12 | TWO ALGORITHMS FOR LC^1 UNCONSTRAINED OPTIMIZATION显示文摘In this paper we present two algorithms for LC1 unconstrained optimization problems which use the second order Dim upper directional derivative. These methods are simple and easy to perform. We discuss the related properties of the iteration function, and establish the global and superlinear convergence of our methods. | Wen-yu Sun R.J.B.de Sampaio Jin-Yun Yuan | 2000 | Journal of Computational Mathematics2000，18，6： | 3 |
| 13 | Nonmonotone adaptive trust region method based on simple conic model for unconstrained optimization显示文摘 | Lijuan ZHAO Wenyu SUN Raimundo J. B. de SAMPAIO | 2014 | Frontiers of Mathematics in China2014，9，5： | 3 |
| 14 | The effect of endoscopic sphincterotomy on acute and chronic complications of biliary endoprostheses显示文摘 | Craig Margulies Eduardo Sampaio Siqueira William Bruce Silverman Xue Sen Lin John Anthony Martin Mordechai Rabinovitz Adam Slivka | 1999 | Gastrointestinal Endoscopy1999，，6： | 2 |
| 15 | Prognostic value of endothelial dysfunction in type 1 diabetes mellitus显示文摘Patients with diabetes mellitus are at high risk of developing atherosclerosis, associated with higher rates of micro and macro vascular involvement such as coronary artery disease and renal disease. The role of hyperglycemia to induce synthesis of reactive oxygen species by the oxidation of glucose, leading to an increased production of advanced glycosylation end products, as well as inflammation and oxidative stress has been proposed as a possible mechanism in the pathogenesis of endothelial dysfunction(ED). The interaction between C-peptide- the connecting segment of pro-insulin-and nitric oxide in vasodilation is also discussed. Therefore, endothelial dysfunction has been identified as an early marker of vascular disorder in type 1 and type 2 diabetes mellitus. In some other diseases, ED has been considered an independent predictor of vascular disease, regardless of the method used. Studies have demonstrated the importance of endothelial dysfunction as an useful tool for identifying the risk of vascular complications in patients with type 1 diabetes mellitus, particularly as regards to renal impairment. The aim of this review is to clarify the prognostic value of endothelial dysfunction as a marker of vascular disease in these subjects. | Ana Marice Ladeia Raphael Ribeiro Sampaio Maiara CostaHita Luis F Adan | 2014 | World Journal of Diabetes2014，5，5： | 2 |
| 16 | A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil显示文摘 | Bonnet R Sampaio JL Labia R | 2000 | Antimicrob Agents Chemother2000，44，7： | 2 |
| 17 | PowerPlex■ fusion 6C system: internal validation study显示文摘This work is aimed at describing the proceedings and parameters used to validate PowerPlex■ Fusion 6C System,the polymerase chain reaction (PCR) amplification kit by Promega,for posterior implementation in the laboratorial routine of the Forensic Genetic Service.The PowerPlex■ Fusion 6C System allows multiplex PCR,through simultaneous amplification and posterior detection by fluorescence of 27 loci.Characterization of the kit was made according to the laboratory's internal validation procedure based on validation guidelines from Scientific Working Group on DNA Analysis Methods.Some parameters were evaluated,such as specificity,analytical thresholds,sensitivity,precision,mixture studies,DNA control samples,a proficiency test and changes in the PCR-based procedures: final reaction volume and cycle number,changes in the reaction mixture for direct amplification.This kit proved to be very robust and the results are in concordance with previous developmental validation by the manufacturer.In some parameters,the results were better than expected. | Ana Boavida Vanessa Bogas Lisa Sampaio Nair Gouveia Maria J.Porto Francisco Corte-Real | 2018 | Forensic Sciences Research2018，3，2： | 2 |
| 18 | Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates显示文摘High-fat diets affect male reproduction and sexual function.Therefore,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria diet.Male Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)groups.At 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 months.Animals were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further analysis.Data were analyzed by one-way ANOVA,and P<0.05 was considered statistically significant.The CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C group.However,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis. | Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio Bianca M Gregorio | 2019 | Asian Journal of Andrology2019，21，2： | 2 |
| 19 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 20 | The corpus cavernosum after treatment with dutasteride or finasteride: a histomorphometric study in a benign prostatic hyperplasia rodent model显示文摘 | Marcello H A Da Silva Waldemar S Costa Francisco J B Sampaio Diogo B De Souza | 2018 | Asian Journal of Andrology2018，20，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员