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| 1 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 2 | Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats显示文摘The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin(50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen(BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide(NO), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH), total antioxidant capacity(TAC),kidney injury molecule-1(KIM-1), heat shock protein-70(HSP-70), caspase-3, transforming growth factor β1(TGFβ1), DNA degradation by the comet assay and total protein contents. Histopathologic study was also done for the kidney and the pancreas. Drastic changes in all measured parameters of the diabetic rats were observed. Treatment with melatonin and rowatinex showed amelioration to variable degrees. In conclusion, melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy followed by its combination with rowatinex. | Tarek K Motawi Samia A Ahmed Manal A Hamed Shohda A El-Maraghy Wessam M Aziz | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 3 | Spectrophotometric determination of ciprofloxacin,enrofloxacin and pefloxacin through charge transfer complex formation显示文摘 | Samia M Wohamad E S Esmail A A | 2002 | J Pharm Biomed Anal2002，27，： | 1 |
| 4 | A new crop yield forecasting model based on satellite measurements applied across the Indus Basin, Pakistan显示文摘 | Bastiaanssen W G M Samia A | 2003 | Agriculture Ecosystems and Environment2003，94，： | 1 |
| 5 | Minor myocardial injury after electiveun complicated successful PTCA with or without stenting:Detec2tion by cardiact roponins显示文摘 | Sala M Mohd A Samia H | 2001 | Cat het Cardiovasc Interv2001，53，2： | 1 |
| 6 | Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting:detection by cardiac troponins显示文摘 | Salam M Mohd A Samia H | 2001 | Cathet and Cardiovasc Interv2001，53，： | 1 |
| 7 | Monitoring of thepesticide levels in some water supplies and agricultural land,inEI-Haram,Giza显示文摘 | E I-Kabbany Samia Rashed M M Zayed M A | 2000 | Journal of Hazardous Matrials2000，72，1： | 1 |
| 8 | Antibactererial activity and chemical compisition of 20Eucalyptus species,essential oils显示文摘 | AMEUR E A KARIMA H S B SAMIA M D | 2011 | Food Chemistry2011，，129： | 1 |
| 9 | Uptake of Copper Ions by Carbon Fiber/Polymer Hybrids Prepared by Tandem Diazonium Salt Chemistry and in Situ Atom Transfer Radical Polymerization显示文摘 | Samia M C Nourredine A Tarik M | | 0，，： | 1 |
| 10 | Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting:Detection by cardiac troponins显示文摘 | Sala M Mohd A Samia H | 2005 | Cathet Cardiovasc Interv2005，53，： | 1 |
| 11 | 查看详情显示文摘 | Samia A C S Hyzer K Schlueter J A Qin C J Jiang J S Bader S D Lin X M | | 0，，12： | 1 |
| 12 | Spectrophotometric determination of ciprofloxacin, enrofloxacin and pefloxacin through charge transfer complex formation显示文摘 | Samia M Mohamed E Eamail A A | 2002 | J Pharm Biomed Anal2002，27，： | 1 |
| 13 | Synthesis, assembly and physical properties of magnetic nanoparticles显示文摘 | LIN X M SAMIA A C S | 2006 | Journal of Magnetism and Magnetic Materials2006，305，： | 1 |
| 14 | Content of antinut-ritional factors and HCl-extractability of minerals from white bean(Phaseolus vulgaris) cultivars, influence of soaking andor cooking显示文摘 | HAGIR B E SAMIA M A WISAL H I | 2007 | Food Chemistry2007，，100： | 1 |
| 15 | Syndnesis and biological study of some amino acid funetionalized starch-graft-polyaerylamide显示文摘 | Samia A S Magda M A | 2006 | Carbohydrate Polymers2006，64，2： | 1 |
| 16 | Monitoring of the pesticide levels in some water supplies and agricultural land,in El-Harm,Giza (A.R.E)显示文摘 | Samia E1-Kabbany Rashed M M Zayed M A | | 0，，： | 1 |
| 17 | Monitoring of the pesticide levels in some water supplies and agricultural land, in EI-Haram, Giza显示文摘 | EI-Kabbany Samia Rashed M M Zayed M A | 2000 | Journal of Hazardous Matrials2000，72，1： | 1 |
| 18 | Synthesis and biological study of some amino acid functionalized starch-graft-polyacrylamide显示文摘 | Samia A S Magda M A | 2006 | Carbohydrate Polymers2006，64，2： | 1 |
| 19 | Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection显示文摘Hepatitis C virus(HCV)is a common cause of liver disease and is associated with various extrahepatic manifestations(EHMs).This mini-review outlines the currently available treatments for HCV infection and their prognostic effect on hepatic manifestations and EHMs.Direct-acting antiviral(DAA)regimens are considered pan-genotypic as they achieve a sustained virological response(SVR)>85%after 12 wk through all the major HCV genotypes,with high percentages of SVR even in advanced fibrosis and cirrhosis.The risk factors for DAA failure include old males,cirrhosis,and the presence of resistance-associated substitutions(RAS)in the region targeted by the received DAAs.The effectiveness of DAA regimens is reduced in HCV genotype 3 with baseline RAS like A30K,Y93H,and P53del.Moreover,the European Association for the Study of the Liver recommended the identification of baseline RAS for HCV genotype 1a.The higher rate of hepatocellular carcinoma(HCC)after DAA therapy may be related to the fact that DAA regimens are offered to patients with advanced liver fibrosis and cirrhosis,where interferon was contraindicated to those patients.The change in the growth of pre-existing subclinical,undetectable HCC upon DAA treatment might be also a cause.Furthermore,after DAA therapy,the T cell-dependent immune response is much weaker upon HCV clearance,and the down-regulation of TNF-αor the elevated neutrophil to lymphocyte ratio might increase the risk of HCC.DAAs can result in reactivation of hepatitis B virus(HBV)in HCV coinfected patients.DAAs are effective in treating HCV-associated mixed cryoglobulinemia,with clinical and immunological responses,and have rapid and high effectiveness in thrombocytopenia.DAAs improve insulin resistance in 90%of patients,increase glomerular filtration rate,and decrease proteinuria,hematuria and articular manifestations.HCV clearance by DAAs allows a significant improvement in atherosclerosis and metabolic and immunological conditions,with a reduction of major cardiovascular events.They also improve physical function,fatigue,cognitive impairment,and quality of life.Early therapeutic approach with DAAs is recommended as it cure many of the EHMs that are still in a reversible stage and can prevent others that can develop due to delayed treatment. | Iman Ibrahim Salama Hala M Raslan Ghada A Abdel-Latif Somaia I Salama Samia M Sami Fatma A Shaaban Aida M Abdelmohsen Walaa A Fouad | 2022 | World Journal of Hepatology2022，14，6： | 0 |
| 20 | A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model显示文摘AIM: To study of the effect of caffeic acid phenethyl ester (CAPE) on the initiation period in a medium-term assay of hepatocarcinogenesis. METHODS: Male Wistar rats were subjected to a carcinogenic treatment (CT) and sacrificed at 25th d; altered hepatic foci (AHF) were generated efficiently. To a second group of rats a single 20 mg/kg doses of CAPE was given 12 h before initiation with CT and were sacrificed at 25th d. We evaluated the expression of preneoplastic markers as γ-glutamyltranspeptidase (GGT) and glutathione S-transferase type pi protein (GSTp) by histochemistry, RT-PCR and Western blot analyses, respectively. We measured thiobarbituric acid reactive substances (TBARS) in homogenates of liver and used Unscheduled DNA Synthesis (UDS) assay by incorporation of [3H] thymidine (3HdT) in primary hepatocyte cultures (PHC). RESULTS: At 25th d after CT CAPE reduced the observed increase of GGT+AHF by 84% and liver expression of ggt mRNA by 100%. In case of the GSTp protein, the level was reduced by 90%. As indicative of oxidative stress generated by diethylnitrosamine (DEN) 12 h after its administration, we detected a 68% increase of TBARS. When CAPE was administered before DEN, it completely protected from liver TBARS induction. To have an indication of the sole effect of CAPE on initiation, twocarcinogens were tested in a UDS assay in PHC, we used methyl-n-nitrosoguanidine as a direct carcinogen and DEN, as indirect carcinogen. In this assay, genotoxic damage caused by carcinogens was abolished at 5μM CAPE concentration. CONCLUSION: Our results demonstrated that CAPE possesses anti-genotoxic and antineoplastic capabilities, by an anti-oxidative and free-radical scavenging mechanism. | Claudia Esther Carrasco-Legleu Yesennia Sánchez-Pérez Lucrecia Márquez-Rosado Samia Fattel-Fazenda Evelia Arce-Popoca Sergio Hernández-García Saúl Villa-Trevio | 2006 | World Journal of Gastroenterology2006，12，42： | 0 |
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