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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 4 | Intracorneal rings to correct corneal ectasia after laser in situ keratomileusis 显示文摘 | Alio J Salem T Artola A | 2002 | J Cataract Refract Surg2002，28，9： | 2 |
| 5 | Plasticity of Mouse Brain Docosahexaenoic Acid:Modulation by Diet and Age 显示文摘 | Morignchi T Haranma A Salem N | 2013 | Lipids2013，48，4： | 1 |
| 6 | Characterization of a virion occlusion-defective Autographa californica multiple nucleopolyhedrovirus mutant lacking the p26,p10and p74genes显示文摘 | Wang L Salem T Z Campbell D J Turney C M Kumar C M Cheng X W | 2009 | J Gen Virol2009，90，7： | 1 |
| 7 | The use of soluble corrosion inhibitors for aluminium alloys显示文摘 | Salem T M Horvath J Sidky P S | 1978 | Corrosion Science1978，18，11： | 1 |
| 8 | PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: two hits on the gene? 显示文摘 | HUHNS M SALEM T SCHNEIDER B | 2014 | Oncol Rep2014，31，5： | 1 |
| 9 | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunc- tion显示文摘 | Hu G Vasiliauskas T Salem M R | 2003 | Anesthesiology2003，98，3： | 1 |
| 10 | Transforming growth factor-13 impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line显示文摘 | Salem S Harris T Mok JS | 2012 | Br J Pharmacol2012，166，： | 1 |
| 11 | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction显示文摘 | Hu G Vasiliauskas T Salem MR | 2003 | Anesthesiology2003，98，3： | 1 |
| 12 | Barraquer-Simons syndrome in a patient with systemic lupus erythematosus 显示文摘 | Ben Ghorbel I Ben Salem T Lamloum M | 2010 | Rev Med Interne2010，31，5： | 1 |
| 13 | a - lino- lenic acid supplementation and conversion to n -3 long- chain polyunsaturated fatty acids in humans 显示文摘 | BRENNA J T SALEM N SINCLAIR A J | 2009 | Prostaglandins Leukot Essent Fatty Acids2009，80，2： | 1 |
| 14 | Initial evaluation and referral guidelines for management of pelvic/ovarian masses 显示文摘 | Le T Giede C Salem S | 2009 | J Obstet Gynaecol Can2009，31，7： | 1 |
| 15 | Prospective study on the role of C-reactive protein (CRP) in patients with an acute abdomen显示文摘 | Salem T A Molloy R G O'dwyer P J | 2007 | Ann R Coil SurgEngl2007，89，3： | 1 |
| 16 | Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain显示文摘 | Winston - Salem N C Deer T R Charleston W V | 2011 | Pain Physician2011，14，： | 1 |
| 17 | Two viruses that cause salivary gland hypertrophy in Glossina pallidipes and Musca domestica are related and form a distinct phylogenetic clade显示文摘 | GARCIA-MARUNIAK A ABD-ALLA A M M SALEM T Z | 2009 | Journal of General Virology2009，90，： | 1 |
| 18 | Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration 显示文摘 | MORIGUCHI T GREINER R S SALEM N Jr | 2000 | Journal of Neuro- chemistry2000，75，6： | 1 |
| 19 | Key management scheme for mobile wireless sensor networks显示文摘 | Foad Salem Mubarek Sufyan T Faraj | 2012 | J of University of Anbar for Pure Science2012，6，2： | 1 |
| 20 | Decreased alpha-synuelein in cerebrospinal fluid of aged indi viduals anti SUhjects with Parkinson's disease显示文摘 | Tokuda T Salem SA Allsop D | | 0，，01： | 1 |
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