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| 1 | A preliminary study of neck-stomach syndrome显示文摘AIM: To determine the expression of c-Fos, caspase-3 and interleukin-1β (IL-1β) in the cervical cord and stomach of rats with cervical spondylosis, to analyze their relationship, and to offer an explanation of one possible cause for functional dyspepsia (FD) and irritable bowel syndrome (IBS) caused by cervical spondylosis. METHODS: The cervical spondylosis model in rats was established by destroying the stability of cervical posterior column. The cord segments C4-6 and gastric antrum were collected 3 mo and 5 mo after the operation. Rats with the sham operation were used as controls. The expressions of c-Fos, caspase-3 and IL-1β in the cervical cord and gastric antrum were determined by immunohistochemistry and/or Western blot. RESULTS: Immunohistochemical staining showed a few c-Fos, caspase-3 and IL-1β-positive cells in the cervical cord and antrum in the control. There was a significant increase in c-Fos, caspase-3 and IL-1β expression in model groups compared to the control groups at 3 mo and 5 mo after operation. More importantly, there was a significant (P < 0.05) increase in c-Fos, caspase-3 and IL-1β expression in the model group rats at 3 mo compared to those at 5 mo after the operation (c-Fos: 11.20 ± 2.26 vs 27.68 ± 4.36 in the cervical cord, 11.3 ± 2.3 vs 29.3 ± 4.6 in the gastric antrum; caspase-3: 33.83 ± 3.71 vs 36.32 ± 4.01 in the cervical cord, 13.23 ± 3.21 vs 26.32 ± 4.01 in the gastric antrum; IL-1β: 42.06 ± 2.95 vs 45.91 ± 3.98 in the cervical cord, 26.56 ± 2.65 vs 32.01 ± 2.98 in the gastric antrum). Western blotanalysis showed time-dependent changes of caspase-3 and IL-1β protein in the cervical cord and gastric antrum of rats with cervical spondylosis; there was no significant expression of caspase-3 and IL-1β protein in the control group at 3 mo and 5 mo after the sham operation, whereas there was a significant difference in caspase-3 and IL-1β protein levels between the model group rats followed up for 3 mo and those for 5 mo (P < 0.05). CONCLUSION: There is a significant association of c-Fos, caspase-3 and IL-1β expressions in the gastric antrum with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. | Xing-Hua Song Xiao-Xiong Xu Li-Wen Ding Li Cao Alken Sadel Hao Wen | 2007 | World Journal of Gastroenterology2007，13，18： | 2 |
| 2 | Facile detection of mitochondrial DNA mutations in tumor and bodily fluids 显示文摘 | Fliss MS Sadel HU Otavis L | 2000 | Science2000，287，17： | 1 |
| 3 | The effect of homgenisation on cold deformations of AA2014 and AA6063 alloys显示文摘 | Totik Y Sadeler R Kaymaz I | 2004 | Materials Processing Technology2004，147，： | 1 |
| 4 | The effect of homogenisation treatment on cold deformations of AA 2014 and AA 6063 alloys显示文摘 | Y. Totik R. Sadeler I. Kaymaz M. Gavgali | 2003 | Journal of Materials Processing Tech2003，，： | 1 |
| 5 | Crystal chemistry, single crystal X-ray structure and magnetism of nickel manganese pyrophosphate 显示文摘 | Benkhouja K Zahir M Sadel A | 1995 | Materials Research Bulletin1995，30，： | 1 |
| 6 | Effect of mechanical dyssynchrony and cardiac resynchronization therapy on left ventricular rotational mechanics 显示文摘 | SadeLE Demir O Atar I | 2008 | Am J Cardiol2008，101，8： | 1 |
| 7 | Regional correlation by colorcoded tissue Doppler to quantify improvements in mechanical left ventricular synchrony after biventricular pacing therapy显示文摘 | KANZAKIH JACQUESD SADELE | 2003 | Am J Cardiol2003，92，： | 1 |
| 8 | The effect ofhomogenisation treatment on cold deformations of AA 2014 andAA 6063 alloys 显示文摘 | Totik Y Sadeler R Kaymaz I | 2004 | Mater Process Technol2004，147，： | 1 |
| 9 | The effect of homogenisation treatment on cold deformations of AA 2014 and AA 6063 alloys显示文摘 | TOTIK Y SADELER R KAYMAZ I | 2004 | Journal of Materials Processing Technology2004，147，1： | 1 |
| 10 | Nanoparticles, a drug carrier system to pass the bloodbrain harrier, permit central analgesic effects of i v dalarg in injections显示文摘 | Schroder U Sadel BA | 1996 | Brain Res1996，710，12： | 1 |
| 11 | The effect of homgenisation on cold deformations of AA2014 and AA6063 alloys 显示文摘 | Totik Y Sadeler R Kaymaz I | 2004 | Materials Processing Technology2004，147，： | 1 |
| 12 | The effect of homogenisation treatment on cold deformations of AA 2014 and AA 6063 alloys显示文摘 | TOTIK Y SADELER R KAYMAZ I GAVGALI M | 2004 | Journal of Materials Processing Technology2004，147，12： | 1 |
| 13 | The effects of arti- ficial aging on wear properties of AA6063 alloy显示文摘 | GAVGALI M TOTIK Y SADELER R | 2003 | Materials Letters2003，57，2425： | 1 |
| 14 | Effect of a commercial hard anodizing on the fatigue property of a 2014-T6 aluminium alloy显示文摘 | R·Sadeler | 2006 | J Mater SciJ Mater Sci2006，，41： | 1 |
| 15 | Improvements of fatigue behav- ior in 2014 A1 alloy by solution heat treating and age-hardening 显示文摘 | Sadeler R Totik Y Gavgali M | 2004 | Material Design2004，25，： | 1 |
| 16 | The effect of homogenisation treatment on cold deformations of AA 2014 and AA 6063 alloys 显示文摘 | TOTIK Y SADELER R KAYMAZ I GAVGALI M | 2004 | Journal of Materials Processing Technology2004，174，1： | 1 |
| 17 | The effects of artificial aging on wear properties of AA 6063 alloy显示文摘 | GAVGALI M TOTIL Y SADELER R | 2003 | Materials Letters2003，57，： | 1 |
| 18 | The effects of artificial aging on wear properties of AA 6063 alloy显示文摘 | GAVGALI M TOTIK Y SADELER R | 2003 | Materials Letters2003，57，： | 1 |
| 19 | The effects of induction hardening on wear properties of AISI 4140 steel in dry sliding conditions显示文摘 | Totik Y Sadeler R Altun H Gavgali M | 2003 | Materials and Design2003，24，1： | 1 |
| 20 | Improvement of fatigue behavior in 2014 AI alloy by solution heat treating and age-hardening 显示文摘 | Sadeler R Totik Y Gavgal I M | 2004 | Materials and Design2004，6，5： | 1 |
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