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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 3 | Use of omental patch and endoscopic closure technique as an alternative to surgery after endoscopic full thickness resection of gastric intestinal stromal tumors: A series of cases显示文摘BACKGROUND Gastrointestinal stromal tumors(GISTs)originate from interstitial cells of Cajal.GISTs can occur anywhere along the gastrointestinal tract.Large lesions have traditionally been removed surgically.However,with recent innovations in advanced endoscopy,GISTs located within the stomach are now removed endoscopically.We describe a new innovative endoscopic technique to close large and hard to access defects after endoscopic full-thickness resection of gastric GISTs.CASE SUMMARY We present a series of three patients who were diagnosed with a gastric GIST.All patients underwent full-thickness endoscopic resection.In all cases,for closure of the surgical bed,conventional endoscopic techniques including hemoclips,endoloop and suturing were unsuccessful.We performed a new technique in which we pulled omental fat into the gastric lumen and completely closed the defect using endoscopic devices.All patients performed well post-procedure and computed tomography was carried out one day after the procedures which showed no extravasation of contrast.CONCLUSION The omental plug technique may be used as an alternative to surgery in selected cases of gastric perforation. | Amit H Sachdev Shahzad Iqbal Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura | 2020 | World Journal of Clinical Cases2020，8，1： | 2 |
| 4 | Zinc deficiency in pregnancy and fetal outcome 显示文摘 | SHAH D SACHDEV H P S | 2006 | Nutrition Reviews2006，64，1： | 1 |
| 5 | Theneuropsychological profile of vascular cognitive inlpairment in stroke and TIA patients显示文摘 | Sachdev PS Brodaty H Valenzuela M J | 2004 | Neurology2004，62，6： | 1 |
| 6 | Acute bleeding after argon plasma coagulation for weight regain after gastric bypass: A case report显示文摘Roux-en-Y gastric bypass(RYGB)is the most commonly performed surgical procedure used to treat obesity worldwide.Despite satisfactory results in terms of weight loss,over time many patients experience weight regain.There are many factors that contribute to weight regain after RYGB,including the diameter of the gastric-jejunal anastomosis(GJA).One of the most commonly performed endoscopic procedures for weight regain after RYGB is argon plasma coagulation(APC).We report a case of hematemesis after outlet revision with APC.We highlight several treatment modalities that can be used to treat this complication.CASE SUMMARY A 45-year-old female with a history of weight regain after RYGB was referred for possible endoscopic treatment for weight regain.On endoscopic evaluation,the diameter of the GJA was 22 mm.Due to the dilated GJA,treatment with APC was performed.Several months later she reported a return of poor satiety and an increased appetite.A repeat endoscopy was then performed.The GJA was approximately 15 mm and was incompetent.APC was performed.One day post procedure she had four episodes of hematemesis.An endoscopy was performed and a large ulcer with a visible arterial vessel was visualized at the GJA.Coagulation was attempted using a Coagrasper and after initial contact with the vessel,the vessel started oozing.Due to fibrosis and the depth of ulceration in the area,clips and repeat APC could not be used.Therefore,an attempt to inject epinephrine injection was made.However,persistent oozing was noted.As a result,hemostatic powder was applied to the region of the bleeding vessel.Subsequently,no more bleeding was observed.On follow-up,the patient remained hemodynamically stable and a second look endoscopy was not performed.The patient was discharged three days later.CONCLUSION APC revision of the GJA is known to be a relatively safe and effective strategy to manage weight regain post RYGB.Anastomotic site bleeding is an infrequent and potentially life-threatening complication associated with this therapy.Endoscopic management is the first line therapy used to achieve hemostasis in these cases. | Diogo Turiani Hourneaux de Moura Amit H Sachdev Po-Wen Lu Igor Braga Ribeiro Christopher C Thompson | 2019 | World Journal of Clinical Cases2019，7，15： | 1 |
| 7 | The deter- minants and longitudinal course of post - stroke mild cognitive impairment 显示文摘 | Sachdev PS Chen X Brodaty H | 2009 | J lnt Neuropsychol Soc2009，15，： | 1 |
| 8 | Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke-the Sydney Stroke Study显示文摘 | Brodaty H Sachdev P S Withall A | 2005 | Psychol Med2005，35，12： | 1 |
| 9 | Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the human lens:implications for cortical cataract formation显示文摘 | Sachdev N H Girolamo N D Nolan T M | 2004 | Invest Ophthalmol Vis Sci2004，45，11： | 1 |
| 10 | The neuropsychological profile of vascular impairment in stroke and TIA patients显示文摘 | Sachdev PS Broady H Valenzuela MJ | | 0，，06： | 1 |
| 11 | Right ventricular strain for prediction of surviv- al in patients with pulmonary arterial hypertension 显示文摘 | SACHDEV A VILLARRAGA H R FRANTZ R P | 2011 | Chest2011，189，： | 1 |
| 12 | A least error square technique for determine power system frequency显示文摘 | SACHDEV M S WOOD H C JOHNSON N | 1985 | IEEE Trans on Power Apparatus and Systems1985，104，2： | 1 |
| 13 | Homocysteine as a risk factor for cognitive impairment in stroke patients 显示文摘 | Sachdev PS Valenzuela MJ Brodaty H | 2003 | Dement Geriatr Cogn Disord2003，15，3： | 1 |
| 14 | Reproductive health and child heahh and nutrition in India:meeting the challenge 显示文摘 | Paul V K Sachdev H S Mavalankar D | 2011 | The Lancet2011，377，9762： | 1 |
| 15 | The neuropsy- chological profile of vascular impairment in stroke and TI A pa- tients显示文摘 | Sachdev PS Broady H Valenzuela MJ | 2009 | Neurology2009，62，6： | 1 |
| 16 | The neuropsychological profile of vascular cognitive impairment in stroke patients显示文摘 | Sachdev PS Brodaty H Valenzuela M | 2003 | Int Psychogeriatr2003，15，2： | 1 |
| 17 | A busbar protection technique and its performance during saturation and CT ratio-mismatch显示文摘 | Sachdev M S Sidhu T S Gill H S | 2000 | IEEE Transactions on Power Delivery2000，15，3： | 1 |
| 18 | The neuropsychological profile of vascular cognitive impairment in stroke and TIA paitents 显示文摘 | Sachdev PS Brodaty H Valenzuela M J | 2004 | Neurology2004，62，6： | 1 |
| 19 | The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients 显示文摘 | Sachdev PS Brodaty H Valeuzuela M J | 2004 | Neurology2004，62，6： | 1 |
| 20 | A power transformer protection technique with stability during current transformer saturation and ratio-mismatch conditions显示文摘 | Sidhu T S Gill H S Sachdev M S | 1999 | IEEE Transactions on Power Delivery1999，14，3： | 1 |
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